Person: KURU, LEYLA
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KURU
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LEYLA
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Publication Open Access Cytotoxicity of Different Nano Composite Resins on Human Gingival and Periodontal Ligament Fibroblast Cell Lines: An In Vitro Study(MDPI, 2020-03-01) YILMAZ GÖLER, AYŞE MİNE; Kavuncu, Gamze; Yilmaz, Ayse Mine; Yilmaz, Betul Karademir; Atali, Pinar Yilmaz; Altunok, Elif Cigdem; Kuru, Leyla; Agrali, Omer BirkanThe aim of this study is to determine the cytotoxicity of three different nano composite resins (CRs) on human gingival fibroblast (hGF) and periodontal ligament fibroblast (hPDLF) cell lines. These CRs selected were nanohybrid organic monomer-based Admira Fusion (AF), nanohybrid Bis-(acryloyloxymethyl) tricyclo [5.2.1.0.sup.2,6] decane-based Charisma Topaz (CT), and supra nano filled resin-based Estelite Quick Sigma (EQS). MTT assay was performed to assess the cytotoxicity of CRs at 24 h and one week. AF and EQS applied on hGF cells at 24 h and one week demonstrated similar cytotoxic outcomes. Cytotoxicity of CT on hGF cells at one week was higher than 24 h (p = 0.04). Cytotoxicity of CT on hGF cells was higher at 24 h (p = 0.002) and one week (p = 0.009) compared to control. All composites showed higher cytotoxicity on hPDLF cells at one week than the 24 h (AF; p = 0.02, CT; p = 0.02, EQS; p = 0.04). AF and EQS demonstrated lower cytotoxicity on hPDLF cells than the control group at 24 h (AF; p = 0.01, EQS; p = 0.001). CT was found more cytotoxic on hPDLF cells than the control (p = 0.01) and EQS group (p = 0.008) at one week. The cytotoxicity of CRs on hGF and hPDLF cells vary, according to the type of composites, cell types, and exposure time.Publication Open Access Osteocalcin and cross‑linked C‑terminal telopeptide of type I collagen in gingival crevicular fluid during piezocision accelerated orthodontic tooth movement: A randomized split‑mouth study(2023-04-01) YILDIRIM, HATİCE SELİN; KURU, LEYLA; Yıldırım H. S., Ateş M., Oktay Gün I., Kuru B., Çakırer B., Kuru L.Background: Piezocision, a minimally invasive surgical procedure, has been used to accelerate tooth movement. Aim: The aim of this randomized split‑mouth study was to evaluate gingival crevicular fluid (GCF) osteocalcin (OC) and type I collagen cross‑linked C‑terminal telopeptide (ICTP) levels during canine distalization with and without piezocision acceleration. Material and Methods: Fifteen systemically healthy subjects (M:F 7:8, 16.27 ± 1.14 years) requiring extraction of maxillary first premolars before retraction of canines were included in the study. Piezocisions were randomly carried out on one of the maxillary canines while bilateral canines served as controls. Canine distalization was conducted using closed‑coil springs applying a force of 150 g/side by using miniscrews as anchorage. GCF sampling was performed from maxillary canine mesial and distal sites at baseline, 1, 7, 14, and 28 days. The GCF levels of OC and ICTP were detected by enzyme-linked immunosorbent assay (ELISA). The rate of tooth movement was evaluated at 2‑week intervals. Results: The amounts of canine distalization from baseline to 14 and 28 days in the piezocision group were significantly higher than the control group (P < 0.05). The GCF OC level of the piezocision group on the tension side and the ICTP level of the same group on the compression side were higher than the respective sides of the control group on day 14 (P < 0.05). Conclusions: Piezocision was found to be an effective treatment procedure for accelerating canine distalization accompanied by increased levels of OC and ICTP.Keywords: ICTP, osteocalcin, piezosurgey, tooth movementPublication Open Access Periodontal treatment approach for dihydropyridine induced gingival overgrowth with or without drug substitution(2022-06-01) ÖZTÜRK ÖZENER, HAFİZE; KURU, LEYLA; Eroğlu O., YETİŞ E., ÖZTÜRK H., KURU L.Objectives: The aim of this study is to evaluate clinical effectiveness of nonsurgical periodontal treatment (NSPT) in patients with drug induced gingival overgrowth (DIGO) with or without drug substitution in comparison with patients presenting inflammatory gingival overgrowth (GO). Material and Methods: A total of 17 patients with generalized GO were included in this clinical trial. Based on the medical physicians consultation, DIGO patients who continued using dihydropyridine were allocated to the Group 1 (n=6), whereas patients whose drug substitution was carried out were allocated to the Group 2 (n=5). Group 3 (n=6) subjects had inflammatory GO. All study groups received NSPT for 4 sessions. At baseline and 6 weeks after NSPT, plaque index, gingival index, bleeding on probing (BOP), probing depth (PD) and, plaster model and photographic GO scores were measured. Results: NSPT resulted in significant decreases in periodontal clinical parameters in all groups (p<0.05). Intergroup comparisons of baseline measurements revealed no statistically significant differences (p>0.05) except PD value which was higher in the Group 1 compared to the Group 2 (p<0.05). Comparisons of post-NSPT data among groups exhibited statistically significant difference only between Groups 1 and 2 in the model and photographic GO scores (p<0.05). Conclusions: After the 6-week evaluation period, NSPT was found to be an effective method in reducing the severity of inflammation and size of overgrown gingival tissues in patients with DIGO and inflamatory GO. Substitution of drug causing GO provided further contribution to NSPT regarding the size of overgrown gingiva in the patients with DIGO.Publication Open Access Peri-implantitis and Severity Level(2020-02) KURU, LEYLA; Elemek, Eser; Agrali, Omer Birkan; Kuru, Bahar; Kuru, LeylaAbstract Objectives Different diagnostic criteria were used for diagnosis of peri-implant diseases. The aim of this cross-sectional study was to explore prevalence of peri-implant diseases and subclassify peri-implantitis based on different levels of radiographic and clinical findings. Materials and Methods Two hundred patients having 655 dental implants were included in this study. In addition to clinical measurements, standard long-cone parallel technique was used to evaluate marginal bone level around implants. Following diagnosis of peri-implant diseases, peri-implantitis was further subclassified using a severity leveling in terms of marginal bone level and probing depth. Results Mean age of 200 subjects was 52.8 ± 12.2 years and 63% were females. In total, bleeding on probing was present in 93% and suppuration in 27% of implants. On subject basis, 2.5% were diagnosed as healthy, 28% with peri-implant mucositis (PM), and 69.5% with peri-implantitis, whereas on implant basis, 3.6% were healthy, 36% presented PM, and 60.4% peri-implantitis. Furthermore, when severity leveling was applied, peri-implantitis prevalence changed markedly and ranged from 14.5 to 31.0% at the subject level and from 10.0 to 22.0% at the implant level. Subgingival restoration margins were observed in 70.6% of patients for implants with PM and in 44% patients for implants with peri-implantitis. Most of the implants with peri-implantitis were with platform match (71.5%). Conclusions Applying different thresholds to the peri-implantitis definition yielded different prevalence rates ranging from 10 to 31%. As no established diagnostic criteria are being used today, results from clinical studies may not reflect the true disease prevalence.Publication Open Access Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects(HINDAWI LTD, 2018-06-28) ÖZBEYLİ, DİLEK; Agrali, Omer B.; Yildirim, Selin; Ozener, Hafize O.; Kose, Kemal N.; Ozbeyli, Dilek; Soluk-Tekkesin, Merva; Kuru, LeylaHyaluronic acid (HA) constitutes one of the major components of the extracellular matrix domain in almost all mammals. The aim of this study was to evaluate the regenerative capacity of HA matrix in rat calvarial bone defects and compare with those of different combinations of resorbable collagen membrane (M) and bovine-derived xenograft (G). Twenty-four 3-month-old male Sprague-Dawley rats weighing 200-250 g were included. Control group was created by leaving one defect empty from 2 critical size defects with 5 mm diameter formed in the calvarial bones of 8 rats. In the same rats, the other defect was treated with HA matrix alone. One of the 2 defects formed in other 8 rats was treated with HA + G and the other with HA + M. One of the 2 defects formed in the remaining 8 rats was treated wilh G+M and the other with HA+G+M. The animals were sacrificed at 4 weeks. Histologic, histomorphometric, and immunohistochemical analyses were performed. Both HA matrix alone and its combinalions with G and M supported new bone formation (NBF). However, NBF was significantly greater in G+M and HA+G+M groups compared to control and HA alone (P < 0.00l). Bone morphogenetic protein-2 was expressed with varying degrees in all groups, without any difference among them. Within the limitations of the present study, HA matrix, used alone or in combination with G and M, did not contribute significantly to bone regeneration in rat calvarial bone defects.Publication Open Access Effect of non-surgical periodontal therapy on salivary melatonin levels(2022-04-01) YARAT, AYŞEN; DOĞAN, BAŞAK; KURU, LEYLA; KUNDAK K., YARAT A., DOĞAN B., KURU L.Objective: Melatonin, a hormone secreted predominantly by pineal gland in a circadian manner, has antioxidant and anti-inflammatory effects. The current research is conducted to explore the influence of non-surgical periodontal therapy (NSPT) on levels of salivary melatonin in subjects with gingivitis and periodontitis. Methods: Sixty systemically healthy participants were included in this study; the groups are as follows: gingivitis (G), chronic periodontitis (CP), generalized aggressive periodontitis (GAP) and periodontally healthy (H). NSPT was applied to G group patients for 2 sessions, to CP and GAP group patients for 4 sessions. Plaque and gingival indices, probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL) were documented at baseline and 3 months post – treatment and early morning salivary samples were collected. ELISA was used to detect melatonin levels in saliva. Pittsburgh Sleep Quality Index (PSQI) questionnaire was performed to evaluate of sleep quality of patients. Results: At baseline, significant difference in gingival index, PD, BOP and CAL values was detected among all groups (p<0.05). Following NSPT, clinical measurements improved in G, CP, and GAP groups significantly (p<0.05). While salivary melatonin concentration of all groups was similar at baseline (p>0.05), a significant elevation in the level of salivary melatonin was found only in the G group after NSPT (p<0.05). PSQI scores differed significantly among groups (p<0.05). Conclusion: The salivary melatonin levels in the presence of gingivitis and periodontitis varied at baseline and elevated following NSPT parallel to the improvement in clinical parameters.Publication Open Access Türkiye’deki diş hekimlerinin perspektifinden dentin hassasiyetinin prevalansı, etiyolojisi, tanı ve tedavi yaklaşımları: Anket çalışması(2023-05-01) YILDIRIM, HATİCE SELİN; KURU, LEYLA; Doğan Ç., Yıldırım H. S., Kuru L.GİRİŞ ve AMAÇ: Dentin hassasiyeti (DH), yetişkin popülasyonu etkileyen ve diş hekimlerinin klinikte sıklıkla karşılaştıkları ağrılı bir durumdur. Bu çalışmanın amacı, Türkiye’deki diş hekimlerinin DH hakkındaki görüş, davranış ve tutumlarını anket aracılığıyla değerlendirmektir.YÖNTEM ve GEREÇLER: Önceki çalışmalardan Türkçe’ye çevrilerek düzenlenen 27 soruyu içeren bu anket, Survey Monkey programında oluşturuldu. Türk Diş Hekimleri Birliği’ne kayıtlı diş hekimlerine e-posta yoluyla gönderilen anketi 217 katılımcı eksiksiz yanıtladı. Veriler tanımlayıcı istatistik, ki-kare ve Fisher exact test kullanılarak analiz edildi.BULGULAR: Hekimlerin %58.06’sı uyguladıkları tedaviler içinde DH tedavisi oranının %10’dan az ve %70.97’si kliniklerine DH şikayeti ile başvuran hastaların sıklıkla 30-39 yaş aralığında olduğunu bildirdi. Hekimlerin %64.52’sinin, hassasiyetin dentin tübüllerindeki sıvı akışı nedeniyle sinirlerin uyarılmasından kaynaklandığını düşündüğü ve %93.03’ünün hava ile uyarma yöntemiyle tanı koyduğu saptandı. Hekimler, hassasiyet tedavisinde en çok zemin hazırlayıcı faktörlerin giderilmesi (%89.40) ve evde hassasiyet giderici ajanların uygulanması (%88.48) seçeneklerini tercih ettiler. Zemin hazırlayıcı faktörlerin giderilmesi, flor verniği, periodontal cerrahi işlemler ve lazer uzman hekimler tarafından istatistiksel olarak anlamlı daha fazla uygulanmaktaydı (p<0.05). Meslekte geçirdiği süre 10 yıldan az olan hekimler, daha tecrübeli hekimlere kıyasla daha çok hassasiyet giderici ajan önermekte ve rezin uygulamaktaydılar (p<0.05). Tedavi sonrası şikayetlerin genellikle 1 hafta içinde geçtiği ve %96.77 oranında nüks ile karşılaşıldığı belirtildi.TARTIŞMA ve SONUÇ: Sonuç olarak, ankete katılan Türkiye’deki diş hekimlerinin çoğunluğunun DH hakkında güncel bilgilere sahip olduğu görülmekle birlikte, hekimler DH tedavisinin başarılı ve uzun süreli sağlanamadığını belirtmişlerdir. Bu çalışma DH’nin ülkemizde çalışan diş hekimleri tarafından hala çözülmesi zor bir sorun olarak görüldüğünü ortaya koymaktadır.Publication Open Access Assessment of reliability of three indices measuring gingival overgrowth procjena pouzdanosti triju indeksa za mjerenje hiperplazije gingive(2023-06-01) ÖZTÜRK ÖZENER, HAFİZE; KURU, LEYLA; Alkateb A. S., ÖZTÜRK ÖZENER H., KURU L.Objectives: Numerous indices have been used to grade the severity of gingival overgrowth which led to suspicion regarding the results concerning its prevalence and pathogenicity. The aim of this study was to assess the concordance of three different gingival overgrowth indices, which were used wide-ly in previous studies, and check their reliability and reproducibility. Material and Methods: A total of 30 full-mouth plaster casts and 90 intra-oral photographs collected from 30 patients diagnosed with gingival overgrowth were included in our study. Three trained examiners performed measurements twice on plaster casts using gingival hyperplasia index (A index) and hyperplastic index (B index). In-traoral photographs were assessed also twice using (C index). Results: Concordance of intra-exam-iner and inter-examiner reliability of the recorded measurements was carried out for each index using weighted kappa (K), with a confidence interval of 95%. The A index revealed intra-examiner total kappa values between 0.724-0.876 for horizontal measurement and 0.512-0.823 for vertical mea-surement, and inter-examiner total kappa values between 0.255-0.626 horizontally and 0.235-0.279 vertically. The B index presented intra-examiner total kappa values between 0.587-0.868 horizontally and 0.653-0.855 vertically; and inter-examiner total kappa values between 0.393-0.595 and 0.372-0.635 for horizontal and vertical measurements, respectively. The C index achieved the highest intra-examiner concordance with total kappa values between 0.758-0.855 and inter-examiner total kappa values between 0.716-0.804. Conclusions: The C index evaluated through intraoral photographs is considered the most reliable and applicable method to be utilized. The C index is suggested to be used in large scale populations with its definite detailed criteria.Publication Open Access Clinical effects of smoking on initial periodontal treatment in patients with stage III grade C(2023-08-01) KURU, LEYLA; YILDIRIM, HATİCE SELİN; İLHAN M. B., GEMREKOĞLU N., KURU L., GÜNGÖRMEK H. S.Objectives: This study aimed to determine the impact of smoking on clinical parameters and GCF volume following initial periodontal therapy (IPT). Materials and Methods: A total of 42 participants, 14 non-smoker periodontally healthy and 28 stages III grade C periodontitis (14 non-smokers and 14 smokers) individuals, were included. All clinical periodontal parameters, plaque index (PI), gingival index (GI), bleeding on probing (BoP), pocket depth (PD), and clinical attachment level (CAL), were recorded and gingival crevicular fluid (GCF) samples were collected from all patients at baseline from all participants, and the first and third months after IPT from periodontitis patients. Results: At baseline, all clinical parameters and GCF volume were lower in healthy group than the periodontitis groups (p<0.001). In the first and third months after IPT, the reductions were seen in all clinical parameters and GCF volüme in non-smoker and smoker stage III grade C periodontitis groups (p<0.001).At three months after IPT, GI, PD and CAL were lower and GCF volume was higher in the non-smoker stage III grade C periodontitis group compared to the smoking stage III stage C periodontitis group (p<0.05). Conclusions: Although improvement was observed with IPT in both non-smoker and smoker periodontitis patients, smoking was found to have a negative effect on IPT.Publication Open Access Treatment of lateral periodontal cyst with guided tissue regeneration(2014-07) KURU, LEYLA; Meseli, Suleyman Emre; Agrali, Omer Birkan; Peker, Onder; Kuru, LeylaABSTRACT Lateral periodontal cyst (LPC), originated from epithelial rests in the periodontal ligament, is a noninflammatory cyst on the lateral surface of the root of a vital tooth. LPC is generally asymptomatic and presents a round or oval uniform lucency with well-defined borders radiographically. In this case report, clinical, histological and radiographical findings and periodontal treatment of 32-year-old female patient, who was referred to Department of Periodontology Clinic of Faculty of Dentistry, Marmara University with a painless hyperplastic lesion on the distobuccal site of the tooth number 12, were presented. The tooth number 12 was vital and a well-defined round radiolucent area with corticated borders was determined radiographically. Preliminary diagnosis was LPC based on clinical and radiographical findings. Mechanical periodontal treatment consisted of oral hygiene instructions, scaling and root planing was applied and flap operation was performed to gain access to the lesion. Following enucleation of the lesion, alveolar bone destruction shaped as a tunnel from labial to palatinal site was observed. The bone cavity was grafted with bovine-derived xenograft, followed by placement of a resorbable collagen membrane. Tissues removed from of the lesion were examined histologically. Hematoxylen-eosin stained sections showed vasculature granulomatous structure underlying squamous epithelium, and destructed bone spaces, all of which were consisted with LPC. Acceptable clinical healing was achieved at 6 months follow-up period. Satisfactory clinical and radiographical outcome can be achieved in the treatment of LPC using regenerative periodontal approach.