Person: BAYRAMİÇLİ, MEHMET NURİ ÜMİT
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BAYRAMİÇLİ
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MEHMET NURİ ÜMİT
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Publication Metadata only Comparison of Bone Prefabrication with Vascularized Periosteal Flaps, Hydroxyapatite, and Bioactive Glass in Rats(THIEME MEDICAL PUBL INC, 2015) ERCAN, FERİHA; Ersoy, Burak; Bayramicli, Mehmet; Ercan, Feriha; Sirinoglu, Hakan; Turan, Pinar; Numanoglu, AyhanBackground Periosteal flaps possess osteoprogenitor cells and an osteoinductive potential that can be further augmented by combination with a biodegradable scaffold; therefore, various osteoconductive and osteostimulative biomaterials are frequently combined with periosteal flaps in studies of bone prefabrication. An experimental study was designed to determine and compare the contribution of bioactive glass and hydroxyapatite to osteoneogenesis in rats when combined with a periosteal flap. Materials and Methods In 60 Sprague Dawley rats, saphenous artery periosto-fasciocutaneous island flaps were transposed to abdomen. In group 1, the flap was left alone, in group 2, an empty artificial pocket made of Gore-Tex (W. L. Gore & Associates, Inc.; Flagstaff, AZ) was sutured onto the periosteal layer, and in groups 3 and 4, the pocket was filled with bioactive glass and hydroxyapatite, respectively. Following sampling for histological analysis, a 4-point scoring system was used to grade inflammatory cell infiltration, osteogenesis, angiogenesis, and cell migration into the bioactive material. Results The combination of the periosteal flap with any of the bioactive materials resulted in significantly higher percentages of animals exhibiting osteogenesis (80% in hydroxyapatite group and 93.3% in the bioactive glass group; p = 0.0000528) and angiogenesis. Comparison of the bioactive material groups revealed that a significantly higher proportion of animals in the bioactive glass group exhibited moderate or severe inflammation (80 vs. 20%; p = 0.002814). Conclusion Periosteal flaps prefabricated with hydroxyapatite or bioactive glass in rats exhibit osteogenic capacities that are not dependent on direct bone contact or proximity to vascular bony tissue. The innate capacity of the periosteal flap when utilized alone for osteoneogenesis was found to be rather insufficient.Publication Metadata only The role of botulinum toxin a injection on neuromuscular end plate reinnervation during peripheral nerve regeneration(2013-05-22) AKDENİZ DOĞAN, ZEYNEP DENİZ; ÖZKAN YENAL, NAZİYE; ERCAN, FERİHA; BAYRAMİÇLİ, MEHMET NURİ ÜMİT; AKDENİZ DOĞAN Z. D., ATEŞ F., ÖZKAN YENAL N., ERCAN F., BAYRAMİÇLİ M. N. Ü.Publication Metadata only The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair(WILEY, 2015) ERCAN, FERİHA; Akdeniz, Zeynep D.; Bayramicli, Mehmet; Ates, Filiz; Oezkan, Naziye; Yucesoy, Can A.; Ercan, FerihaIntroduction: The aim of this study was to test the hypothesis that the increased number of new motor endplates induced by botulinum toxin type A (BTX-A) injection before nerve injury would be reinnervated after nerve repair, resulting in greater force generation. Methods: Thirty male Wistar rats were divided randomly into 3 groups: (1) controls; (2) a group with saline solution injection; and (3) a group with BTX-A injection into gastrocnemius muscle (BTX group). Thirty-six days after the injections the left sciatic nerve was divided and coapted in all groups. Eight weeks later, muscle forces were measured, and histological samples were collected. Results: No differences in the number of innervated endplates were found between the groups, but the number of denervated endplates was higher in the BTX group, as was the muscle tissue degeneration score. The BTX group showed distal muscle force measurements of up to 25.8% less compared with the control group. Conclusion: Although BTX-A injection increases the number of motor endplates, they are not functional. Muscle Nerve 52:412-418, 2015