Person: ABDULLAYEV, RUSLAN
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ABDULLAYEV
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RUSLAN
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Publication Open Access Perioperative hypothermia and associated factors: A prospective cohort study(2023-01-01) ABDULLAYEV, RUSLAN; UMUROĞLU, TÜMAY; Kelleci Y., ABDULLAYEV R., Cakmak G., Ozdemir H., UMUROĞLU T., Saracoglu A.Objective: Perioperative hypothermia is deleterious with many consequences, including coagulopathy, decreased immune functions, prolonged drug clearance, and cardiovascular complications. In this study we aimed to demonstrate the incidence of perioperative hypothermia during general anesthesia, its associated risk factors, and outcomes. Methods: For this prospective cohort study patients aged 18-75 years with American Society of Anesthesiologists physical status I-III scheduled for any elective operation under general anesthesia in a one-month period were recruited. The patients’ body temperatures were measured in the preoperative unit, in the operating theatre before induction, at the second hour of the operation, at the end of the operation, at the postoperative recovery unit admission, and discharge using a medical infrared thermometer. The patients’ demographic and hemodynamic characteristics, magnitudes of surgery, surgery and anesthesia durations, warming methods, hospital and Intensive Care Unit (ICU) length of stays were recorded. Results: Sixty five out of 290 enrolled patients (22.4%) developed perioperative hypothermia. Anesthesia and surgery time was longer in patients with hypothermia (p<0.001). Hospital length of stay of the patients was also longer in the patients with hypothermia (p<0.001). Intensive care unit admission of the patients with hypothermia was significantly higher compared with those with normothermia (2.7 vs 9.2%, p=0.030). Conclusion: Perioperative hypothermia continues to be a challenge despite many published clinical application guidelines in this context. Intermediate and major type surgeries resulted in more perioperative hypothermia. Perioperative hypothermia was significantly associated with longer operation and anesthesia durations, hospital length of stays, and higher ICU admissions as well. Routine monitoring and active warming should be performed throughout the perioperative period to prevent hypothermia and current practice guidelines should be followed.Publication Open Access Continuous hemoglobin measurement during frontal advancement operations can improve patient outcomes(2022-12-01) SARAÇOĞLU, AYTEN; ABDULLAYEV, RUSLAN; SAÇAK, BÜLENT; AYKAÇ, ZEYNEP ZUHAL; SAKAR, MUSTAFA; Saraçoğlu A., Abdullayev R., Sakar M., Saçak B., Incekoy F. G., Aykac Z.Massive hemorrhage in pediatric cranioplasty operations may necessitate blood transfusion, which may cause many complications. Radical-7 Pulse CO-Oximeter (Massimo Corporation, Irvine, CA) can provide continuous hemoglobin concentration (SpHb) measurements noninvasively. In this study, we aimed to evaluate the effects of SpHb measurement on perioperative transfusion management and postoperative patient outcomes. For this retrospective case-control study, we collected the data of pediatric patients undergoing fronto-orbital advancement surgery for plagiocephaly and trigonocephaly between 2018 and 2021. Perioperative SpHb monitoring was performed for patients in the SpHb Group. Other patients that were managed conventionally were considered as the control group (C Group). The data on patients\" demographic and clinical characteristics, intraoperative hemodynamic and laboratory variables such as blood gases, intraoperative blood losses, the amount of the transfused blood products, the length of postoperative intensive care unit (ICU) stay, and the duration of hospital stay were collected. The data of 42 patients were collected, and 29 of these patients were males (69%). In 16 of the patients, SpHb monitoring was performed. The demographic, clinical, and perioperative hemodynamic characteristics of the patients were comparable between the groups. Compared to the C Group, the SpHb Group had significantly lower perioperative packed red blood cell (PRBC) transfusion (136.3 +/- 40.1 vs. 181.5 +/- 74.8 mL, P = 0.015), less postoperative drainage (125.3 +/- 47.7 vs. 185.8 +/- 97.6 mL, P = 0.013), and shorter ICU stay (37.1 +/- 12.0 vs. 64.8 +/- 24.9 h, P < 0.001). There was a positive correlation between the amount of PRBC transfusion and the length of ICU stay (r = 0.459, P = 0.003). Patients with perioperative continuous SpHb measurement have lower intraoperative PRBC transfusion, less postoperative bleeding, and shorter ICU stay. When necessary, SpHb, together with clinical judgment and laboratory confirmation, can be used in decision-making for perioperative PRBC transfusion.Publication Open Access Cytokine Adsorption in Critically Ill COVID-19 Patients, a Case-Control Study(2022-09-01) ABDULLAYEV, RUSLAN; BİLGİLİ, BELİZ; SEVEN, SEDA; CİNEL, İSMAİL HAKKI; GÜL, FETHİ; Abdullayev R., Gül F., Bilgili B., Seven S., Cinel I.Aim: New coronavirus disease (COVID-19) has become an international emergency. As many of the intensive care unit (ICU) patients with the disease also present multiple organ failure, blood purification techniques might be a good choice in their treatment. In this study we aimed to investigate the role of cytokine removal in COVID-19 patients managed in ICUs. Methods: For this case-control study we have investigated the role of the cytokine removal by means of two resin membranes (HA330 and Mediasorb) in COVID-19 patients managed in ICUs. Particularly, we investigated the overtime variation in clinical severity scores, laboratory variables, and effects on hospital and ICU stay and mortality. Results: Seventy-two patients have been evaluated, of which half constituted Cytokine Filtration (CF) Group, and other half the Case-Control (CC) Group. Mortality was 55.6% and 50% in CF and CC groups, respectively. In the CF Group, there was decrease in C-reactive protein (CRP) and fibrinogen levels measured at the end of cytokine adsorption; lymphocyte count and ratio were increased, whereas neutrophile ratio was decreased. There were no differences between the groups regarding other laboratory variables, SOFA scores and vasopressor uses. Conclusions: We have demonstrated decrease in CRP, fibrinogen and increase in lymphocyte count in the patients having cytokine adsorption, but there was no clinical reflection of these benefits, and no decrease in mortality as well. Even though there is physio-pathologic rationale to use cytokine adsorption techniques for immunomodulation in critically ill COVID-19 patients, it is early to make strong suggestions about their benefits.