Person: İNCAZ, SEFA
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İNCAZ
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SEFA
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Publication Open Access Accuracy of Frozen Section Examination in Oral Cavity Cancers(SAGE PUBLICATIONS INC, 2020-11-06) OYSU, ÇAĞATAY; Demir, Berat; Incaz, Sefa; Uckuyulu, Esin Irem; Oysu, CagatayPurpose: This study aimed to compare the intraoperative frozen section with the surgical margin in the postoperative surgical margins of the postoperative pathology of oral squamous cell carcinomas in order to examine the reliability of the frozen section. Methods: A retrospective analysis was conducted for patients who underwent surgery for oral squamous cell carcinoma in a tertiary hospital between January 2018 and 2019. The intraoperative frozen section examinations, grade of the tumor, number of lymph nodes, number of affected lymph nodes, depth of invasion, perineural invasion, lymphovascular invasion, and extranodal extension were recorded from the pathological records. The concordance between the frozen section examination and postoperative pathology 2 methods was examined using the Cronbach alpha coefficient. Sensitivity, specificity, positive predictive value, negative predictive value regarding surgical margins, and accuracy were calculated and reported. Results: Overall, 181patients who underwent surgery for oral cavity cancers were included; 118 (65.2%) were males. The mean (+/- standard deviation) age of the included participants was 57.4 +/- 16.1 years. The most common tumour subsite was the tongue (n = 71, 39.2%). There was concordancy between the frozen, positive intraoperative malignancy and the postoperative pathology malignancy. The frozen, negative intraoperative malignancy and postoperative safe surgical margin did not significantly differ. Conclusion: As a result of intraoperative frozen examination, we found conformity between the postoperative pathology results of patients with positive and negative surgical margins. Frozen section examination could be used safely to examine intraoperative surgical margins of oral squamous cell carcinoma.Publication Open Access Thyroid Surgery and Inadvertent Removal of Parathyroids(SPRINGER INDIA, 2021-06-01) YUMUŞAKHUYLU, ALİ CEMAL; Asya, Orhan; Yumusakhuylu, Ali Cemal; Gundogdu, Yavuz; Incaz, Sefa; Oysu, CagatayThis study aimed to determine the incidence of inadvertent parathyroid removal during thyroid surgery and define its associated risk factors. In this single-center record-based study, we retrospectively analyzed the clinical and pathological records of 462 patients undergoing thyroidectomy. Incidental parathyroidectomy was detected in 61 of 462 patients (13.2%). The incidence of inadvertent parathyroid removal was 17.6% (36 of 205 patients) in patients having malign thyroid diseases, compared with 9.7% (25 of 257 patients) in patients with benign thyroid diseases (p = 0.045). Incidentally removed parathyroid tissue was intrathyroidal in 8 of the 61 patients. Thus, the ratio of intrathyroidal parathyroid tissue among all patients was 1.7% (8 out of 462). Central neck dissection was carried out in 40 patients (8.7%). Fourteen of these 40 patients (35%) had an incidental parathyroid in their specimen compared with 47 of 422 patients (11.1%) who did not undergo central neck dissection (p<0.001). Incidental parathyroidectomy occurred in 13.2% of patients undergoing thyroidectomy in our study. The majority of patients had one parathyroid identified in their specimen. Central neck dissection was significantly predictive for incidental parathyroidectomy. Well-trained senior otolaryngology residents can safely perform thyroid surgery with similar rates of incidental parathyroidectomy as their masters.Publication Metadata only YouTube (TM) as an information source for larynx cancer: a systematic review of video content(SPRINGER, 2020) ENVER, NECATİ; Enver, Necati; Doruk, Can; Kara, Hakan; Gurol, Ece; Incaz, Sefa; Mamadova, UlkerPurpose The increasing availability of Internet as a health-care source causes both positive and negative effects on public health. Though reaching to information about diseases is faster and easier, the contents are not always correct and might be misleading. In our study, we aim to investigate the quality of YouTube (TM) videos on larynx cancer. Methods A YouTube (TM) search by using terms throat cancer and larynx cancer was done and, after eliminating the irrelevant videos, the first 200 videos were evaluated by three authors on quality, content and usefulness by using a pre-developed questionnaire. Videos were categorized according to the type and uploader separately to two (testimonial and educational) and five groups (health care, university, individual users, television channel/news and undetermined), respectively. Results Videos that are uploaded by university-affiliated accounts have significantly better audiovisual quality score and have significantly higher accuracy and usefulness score results. Furthermore, the accuracy and usefulness scores of the educational group were found to be statistically higher than those of the testimonial group. Conclusions Videos uploaded by universities and videos that are created for educational purposes are superior to other sources in terms of quality, accuracy and content. Patient information videos discussing common health problems should be prepared and disseminated only by universities or health-care institutionsPublication Open Access A single-center multidisciplinary study analyzing thyroid nodule risk stratification by comparing the thyroid imaging reporting and data system (TI-RADS) and American thyroid association (ATA) risk of malignancy for thyroid nodules(2022-01-01) ASYA, ORHAN; YUMUŞAKHUYLU, ALİ CEMAL; ENVER, NECATİ; İNCAZ, SEFA; GÜNDOĞMUŞ, CEMAL AYDIN; ERGELEN, RABİA; BAĞCI ÇULÇİ, PELİN; OYSU, ÇAĞATAY; ASYA O., YUMUŞAKHUYLU A. C. , ENVER N., Gündoğdu Y., Abuzaid G., İNCAZ S., GÜNDOĞMUŞ C. A. , ERGELEN R., Bağcı P., OYSU Ç.© 2022 Elsevier LtdObjectives: The thyroid imaging reporting and data system (TI-RADS) and 2015 American Thyroid Association (ATA) guidelines are two well-known risk stratification systems for classifying thyroid nodules based on cancer risk. This study aims to evaluate the diagnostic efficacy of these two systems in predicting malignancy in patients undergoing thyroid surgery. Methods: We studied data on 120 individuals who were scheduled to undergo surgery for benign or malignant nodular diseases of the thyroid gland between October 2017 and October 2019. The TI-RADS category and ultrasound pattern based on ATA guidelines were assigned to dominant thyroid nodule categories by two experienced radiologists blinded to patients’ previous thyroid ultrasonography and fine-needle aspiration biopsy results. A pathologist with experience in thyroid diseases blinded to patients’ sonographic and clinical data reviewed the thyroidectomy specimens. Results: A total of 120 patients, 88 women and 32 men, were included in our study. Final histopathological results were as follows: 50% (n=60) papillary thyroid carcinoma, 36.6% (n=44) benign nodular thyroid diseases, 4.1% (n=5) follicular adenoma, 2.5% (n=3) hurtle cell adenoma, 1.7% (n=2) follicular thyroid carcinoma, 1.7% (n=2) medullary thyroid carcinoma, 1.7% (n=2) hurtle cell carcinoma, and 1.7% (n=2) follicular tumor of uncertain malignancy potential. The sensitivity, specificity, positive predictive value, and negative predictive value for TI-RADS were 80%, 56%, 72%, and 67%, respectively, and that for ATA were 80%, 64%, 76%, and 69%, respectively. Conclusion: The TI-RADS and ATA showed similar rates of sensitivity, specificity, NPV, and PPV. Our observed risk of malignancy was higher than expected for the ACR TI-RADS 3–5 categories and the very low, low, and intermediate suspicion risk strata in the ATA guidelines. We found no difference between observed and expected malignancy risk for the ACR TI-RADS 2’s and ATA\"s high suspicion categories.Publication Open Access Texture Analysis of Thyroid Nodules Using Computed Tomography: Is it a Viable Method for Objective Assessment of Thyroid Nodules?(2024-01-01) İNCAZ, SEFA; YUMUŞAKHUYLU, ALİ CEMAL; İncaz S., Kavak Ö. T., Kersin B., YUMUŞAKHUYLU A. C.Objective: Computed aided detection (CAD) systems can be developed to help radiologists in the accurate interpretation of computed tomography (CT) images. The recently popularised texture analysis method allows for qualitative and quantitative evaluation by analysing the grey-level distribution and relationships within an image. We aimed to compare the ratios of texture analysis data in the differentiation of benign-malignant nodules with the proportions of radiologists in the distinction between benign and malignant nodules and to compare the results. Materials and Methods: Retrospectively, the data of 80 patients who underwent thyroidectomy and had contrast-enhanced neck CT preoperatively were analysed. Two radiologists, experienced in head and neck radiology, blinded to the patients’ data evaluated neck CT images. Manual marking was performed and scanned to take tissue sections from the nodule area in transverse contrast-enhanced CT images, and the size of the nodule in the contralateral normal thyroid parenchyma was almost equal. Results: The computed tomography texture analysis (CTTA) model achieved the highest sensitivity of 81.4%, followed by the first radiologist at 51.2% and the second radiologist at 55.8%. Additionally, the CTTA model achieved the highest accuracy at 61.3%, followed by the first radiologist at 41.3% and second radiologist at 47.5%. On average, the CTTA model performed significantly better than the two radiologists, especially with regard to sensitivity. Conclusion: The CTTA model was superior to both radiologists in differentiating between benign and malignant thyroid nodules. Medical experts can benefit from CTTA-based solutions to extend their understanding of thyroid nodules in their routine practise.