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GÜNEY, AHMET İLTER

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GÜNEY

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AHMET İLTER

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2015 - 20162
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Author: KASIMAY ÇAKIR, ÖZGÜR ×

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    PublicationOpen Access
    Effects of MC4R, FTO, and NMB Gene Variants to Obesity, Physical Activity, and Eating Behavior Phenotypes
    (WILEY, 2016-10) GÜNEY, AHMET İLTER; Kirac, Deniz; Cakir, Ozgur Kasimay; Avcilar, Tuba; Deyneli, Oguzhan; Kurtel, Hizir; Yazici, Dilek; Kaspar, Elif Cigdem; Celik, Nurgul; Guney, Ahmet Ilter
    Obesity is a major contributory factor of morbidity and mortality. It has been suggested that biological systems may be involved in the tendency to be and to remain physically inactive also behaviors such as food and beverage preferences and nutrient intake may at least partially genetically determined. Consequently, besides environment, genetic factors may also contribute to the level of physical activity and eating behaviors thus effect obesity. Therefore the aim of this study is to investigate the effect of various gene mutations on obesity, physical activity levels and eating behavior phenotypes. One hundred patients and 100 controls were enrolled to the study. Physical activity levels were measured with an actical acceloremeter device. Eating behaviors were evaluated using Three-Factor Eating questionnaire (TFEQ). Associations between eating behavior scores and physical characteristics were also evaluated. The information about other obesity risk factors were also collected. Mutations were investigated with PCR, direct sequencing and Real-Time PCR. rs1051168, rs8050146-2778C>T mutations were found statistically significant in patients, rs1121980 was found statistically significant in controls. 21 mutations were found in MC4R and near MC4R of which 18 of them are novel and 8 of them cause amino acid change. In addition, it was found that, some obesity related factors and questions of TFEQ are associated with various investigated gene mutations. Any relation between gene mutations and physical activity levels were not detected. It is thought that, due to the genotype data and eating behaviors, it may be possible to recommend patients for proper eating patterns to prevent obesity. (C) 2016 IUBMB Life, 68(10):806-816, 2016
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    A new method in investigation of obesity-related eating behaviors 'three-factor eating questionnaire'
    (AVES PRESS LTD, 2015) GÜNEY, AHMET İLTER; Kirac, Deniz; Kaspar, Elif Cigdem; Avcilar, Tuba; Cakir, Ozgur Kasimay; Ulucan, Korkut; Kurtel, Hizir; Deyneli, Oguzhan; Guney, Ahmet Ilter
    Objective: TFEQ Three-factor eating questionnaire evaluates eating behaviours of individuals. In this study, it was aimed to provide the usage of this questionnaire, which was translated into Turkish and named as 'Uc Faktorlu Beslenme Anketi by verifying the validity and reliability. Methods: Fifty obese patients with a body mass index greater than 30, 50 overweight individuals with a body mass index between 25 and 30, and 50 healthy individuals with a body mass index smaller than 25 were recruited to the study. Age, gender, waist circumference, weight, height and body mass index values were recorded and the questionnaire was filled up by all individuals. Results: Reliability of the questionnaire was found to be high. In addition, it was detected that, besides the evaluation of cognitive restraint of eating, disinhibition of eating control and emotional eating, the questionnaire also evaluates susceptibility to hunger. Conclusion: Turkish version of the questionnaire could be used for the investigation of eating behaviours by other researchers in our country.