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GÜNEY, AHMET İLTER

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GÜNEY

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AHMET İLTER

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2012 - 20162
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Author: ULUCAN, KORKUT × Has files: true ×

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Now showing 1 - 2 of 2
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    PublicationOpen Access
    Investigation of the association between mitochondrial DNA and p53 gene mutations in transitional cell carcinoma of the bladder
    (SPANDIDOS PUBL LTD, 2016-10) GÜNEY, AHMET İLTER; Avcilar, Tuba; Kirac, Deniz; Ergec, Deniz; Koc, Gulsah; Ulucan, Korkut; Kaya, Zehra; Kaspar, Elif Cigdem; Turkeri, Levent; Guney, Ahmet Ilter
    Bladder carcinoma is the most common malignancy of the urinary tract. The major aim of the present study is to investigate the association between mitochondrial DNA (mtDNA) and p53 gene mutations in bladder carcinoma. A total of 30 patients with transitional cell carcinoma and 27 controls were recruited for the study. Bladder cancer tissues were obtained by radical cystectomy or transurethral resection. Genomic DNA was extracted from peripheral blood. mtDNA and p53 genes were amplified by polymerase chain reaction and sequenced directly. A total of 37 polymorphisms were identified, among which, 2 mutations were significant in the patient group, and 1 mutation was significant in the control group. Additionally, 5 different moderate positive correlations between mtDNA mutations and 3 different positive correlations between p53 gene and mtDNA mutations were detected. The high incidence of mtDNA and p53 gene mutations in bladder cancer suggests that these genes could be important in carcinogenesis.
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    PublicationOpen Access
    Transforming growth factor-beta 3 intron 5 polymorphism as a screening marker for non-syndromic cleft lip with or without cleft palate
    (SPANDIDOS PUBL LTD, 2012-12) GÜNEY, AHMET İLTER; Ulucan, Korkut; Bayraktar, Nazli; Parmaksiz, Emine; Akcay, Arzu; Guney, Ahmet Ilter
    In this study, we evaluated the effect of transforming growth factor beta 3 intron 5 position +104 A -> G (TGF-beta 3 IVS5+104AG) transition in patients with a non-syndromic cleft lip with or without cleft palate (NSCL/P). A total of 68 patients and 114 controls were recruited for the study. A genotyping procedure was carried out using the PCR-RFLP method. For statistical analysis, the Chi-square test was used to compare data between the patient and control groups. The frequencies of the AA, AG and GG genotypes were 24, 29 and 47%, respectively, for the patients and 54, 36 and 10%, respectively, for the control group. The GG genotype and G allele were significantly different in the patient group compared with the control (p=0.0001). We conclude that SfaN1 polymorphism in TGF-beta 3 may be a good screening marker for the prediction of NSCL/P in patients. However, more studies with extended sample numbers should be carried out to clarify the effect of the examined gene region on NSCL/P.