Person: GÜNEY, AHMET İLTER
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GÜNEY
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AHMET İLTER
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Publication Open Access Effects of MC4R, FTO, and NMB Gene Variants to Obesity, Physical Activity, and Eating Behavior Phenotypes(WILEY, 2016-10) GÜNEY, AHMET İLTER; Kirac, Deniz; Cakir, Ozgur Kasimay; Avcilar, Tuba; Deyneli, Oguzhan; Kurtel, Hizir; Yazici, Dilek; Kaspar, Elif Cigdem; Celik, Nurgul; Guney, Ahmet IlterObesity is a major contributory factor of morbidity and mortality. It has been suggested that biological systems may be involved in the tendency to be and to remain physically inactive also behaviors such as food and beverage preferences and nutrient intake may at least partially genetically determined. Consequently, besides environment, genetic factors may also contribute to the level of physical activity and eating behaviors thus effect obesity. Therefore the aim of this study is to investigate the effect of various gene mutations on obesity, physical activity levels and eating behavior phenotypes. One hundred patients and 100 controls were enrolled to the study. Physical activity levels were measured with an actical acceloremeter device. Eating behaviors were evaluated using Three-Factor Eating questionnaire (TFEQ). Associations between eating behavior scores and physical characteristics were also evaluated. The information about other obesity risk factors were also collected. Mutations were investigated with PCR, direct sequencing and Real-Time PCR. rs1051168, rs8050146-2778C>T mutations were found statistically significant in patients, rs1121980 was found statistically significant in controls. 21 mutations were found in MC4R and near MC4R of which 18 of them are novel and 8 of them cause amino acid change. In addition, it was found that, some obesity related factors and questions of TFEQ are associated with various investigated gene mutations. Any relation between gene mutations and physical activity levels were not detected. It is thought that, due to the genotype data and eating behaviors, it may be possible to recommend patients for proper eating patterns to prevent obesity. (C) 2016 IUBMB Life, 68(10):806-816, 2016Publication Open Access PRELIMINARY FINDINGS OF alpha-ACTININ-3 GENE DISTRIBUTION IN ELITE TURKISH WIND SURFERS(MACEDONIAN ACAD SCIENCES ARTS, 2013-06-01) GÜNEY, AHMET İLTER; Ulucan, K.; Gole, S.; Altindas, N.; Guney, A., IA common polymorphism in the alpha-actinin-3 (ACTN3 R577X) gene represents one of the most widely examined variations in terms of performance and genetic predisposition to certain sports. The aim of the present study was to examine the ACTN3 R577X polymorphism in elite Turkish wind surfers. The genotyping procedure was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Five male and three female wind surfers, eight elite wind surfers in total, were enrolled in the study. Five of the surfers had RX, two had XX and one had RR genotypes. Previous findings indicated that the X allele was the endurance allele. Our findings were in agreement with the previous reports. Seven of our subjects had at least one copy of the X allele that was considered to have a tendency to prolong endurance. Our preliminary results must be supported with further studies in greater numbers of subjects to clarify the effect of gene polymorphism.Publication Open Access Transforming growth factor-beta 3 intron 5 polymorphism as a screening marker for non-syndromic cleft lip with or without cleft palate(SPANDIDOS PUBL LTD, 2012-12) GÜNEY, AHMET İLTER; Ulucan, Korkut; Bayraktar, Nazli; Parmaksiz, Emine; Akcay, Arzu; Guney, Ahmet IlterIn this study, we evaluated the effect of transforming growth factor beta 3 intron 5 position +104 A -> G (TGF-beta 3 IVS5+104AG) transition in patients with a non-syndromic cleft lip with or without cleft palate (NSCL/P). A total of 68 patients and 114 controls were recruited for the study. A genotyping procedure was carried out using the PCR-RFLP method. For statistical analysis, the Chi-square test was used to compare data between the patient and control groups. The frequencies of the AA, AG and GG genotypes were 24, 29 and 47%, respectively, for the patients and 54, 36 and 10%, respectively, for the control group. The GG genotype and G allele were significantly different in the patient group compared with the control (p=0.0001). We conclude that SfaN1 polymorphism in TGF-beta 3 may be a good screening marker for the prediction of NSCL/P in patients. However, more studies with extended sample numbers should be carried out to clarify the effect of the examined gene region on NSCL/P.Publication Metadata only Il-6 and UGT1A1 variations may related to furosemide resistance in heart failure patients(2023-01-01) GÜNEY, AHMET İLTER; SÜNBÜL, MURAT; Koprululu Kucuk G., GÜNEY A. İ., SÜNBÜL M., Guctekin T., Koç G., Kirac D.Furosemide is a diuretic and is used for the treatment of patients with heart failure (HF). It has been found that in some HF patients, the drug does not treat patients efficiently. This condition is named as furosemide resistance. In this study, it is aimed to investigate the relationship between UDP-glucuronosyltransferase 1 (UGT1A1) and interleukine-6 (IL-6) variations with furosemide resistance in HF patients. Sixty HF patients using furosemide (patient group) and 30 healthy individuals (control group) were enrolled in this study. Patients were divided into two subgroups as non-responders (furosemide resistant) group (n = 30) and the responders (non-resistant) group (n = 30) according to the presence of furosemide resistance (n = 30). Variations in the first exon of UGT1A1 and rs1800795 and rs1800796 variations in IL-6 were analyzed by direct sequencing and real-time polymerase chain reaction (RT-PCR), respectively. The effects of newly detected mutations on 3-D protein structure were analyzed by in silico analysis. At the end of the study, 11 variations were detected in UGT1A1, of which nine of them are novel and eight of them cause amino acid change. Also, rs1800795 and rs1800796 variations were detected in all the groups. When patient and control groups were compared with each other, rs1800796 mutation in IL-6 was found statistically high in the patient group (p = 0.027). When the three groups were compared with each other, similarly, rs1800796 mutation in IL-6 was found statistically high in the non-responders group (p = 0.043). When allele distributions were compared between the patient and control groups, the C allele of rs1800795 mutation in IL-6 was found statistically high in the patient group (p = 0.032). When allele distributions were compared between the three groups, 55T-insertion in UGT1A1 was found statistically high in the non-responders group (p = 0.017). According to in silico analysis results, two variations were found deleterious and six variations were detected as probably damaging to protein functions. Our study may contribute to the elucidation of pharmacogenetic features (drug response–gene relationship) and the development of individual-specific treatment strategies in HF patients using furosemide.Publication Open Access VDBP and VDR Mutations May Cause In-Stent Restenosis(2022-09-01) GÜNEY, AHMET İLTER; Kirac D., Yaman A. E. , Gezmis H., Yesilcimen K., Avcilar T., GÜNEY A. İ. , Keles E. C. , KOÇ G., Akkanat R., İSBİR T.Objective: In-stent restenosis (ISR) is the narrowing of a stented coronary artery lesion. A considerable number of patients undergoing percutaneous coronary intervention (PCI) are affected by ISR. The predominant mechanism in the development of ISR is an inflammatory response to vessel wall injury during PCI. Vitamin D is reported to have anti-inflammatory properties, so it may also be related with ISR. Therefore, in this study the relationship between vitamin D receptor (VDR), vitamin D binding protein (VDBP) gene variations and ISR were investigated.Methods: Fifty-eight ISR patients who have chest pain, underwent angiography and were found to have restenosis in the previously inserted stent were included in the patient group and thirty-five patients who have chest pain and were not found to have restenosis in their previous stent in coronary angiography were included in the control group. rs7041 and rs4588 variations in VDBP; rs1544410 and rs2228570 variations in VDR were investigated by real-time polymerase chain reaction (RT-PCR).Results were evaluated statistically. Results: The CC genotype of rs2228570 variation of VDR and the CA genotype of rs4588 variation of VDBP were found statistically high in patient group. rs7041 variation was found statistically high in patients who had myocardial infarction history before stent implantation. Additionally, it was demonstrated that vitamin D deficiency (vitamin D level<20 ng/ml) was found statistically high in patient group.Conclusion: It was considered that rs2228570, rs4588 variations and the presence of vitamin D deficiency may play role in the formation of ISR.Publication Metadata only Effect of alpha-actinin-3 gene on trained and untrained Turkish middle-school children's sprinting performance: a pilot study(TAYLOR & FRANCIS LTD, 2014) GÜNEY, AHMET İLTER; Ulucan, Korkut; Bayyurt, Gizem Merve; Konuk, Muhsin; Guney, Ahmet IlterACTN3 R577X polymorphism was evaluated in trained and untrained Turkish middle-school children's sprinting performance. Twenty trained and 30 untrained children were genotyped; the frequencies of RR, RX and XX genotypes were 65, 30 and 5% in the trained individuals and 50, 27 and 23% in the controls ( untrained), respectively. The R allele was present in 80% of the trained and 63% of the untrained individuals, whereas the X allele was present in 20% of the trained and 37% of the untrained individuals. The average values of time taken for running 50 m for the trained and untrained groups were 10.21 +/- 0.68 and 11.88 +/- 1.18 s in RR genotypes, and 10.48 +/- 0.54 and 12.28 +/- 1.26 s in RX genotypes, respectively. These differences were statistically significant and ecologically meaningful. Such polymorphism may form an informative criterion for identifying individuals who might become talented sprinters with suitable training.