Person:
CABADAK, HÜLYA

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

CABADAK

First Name

HÜLYA

Name

Filters

2011 - 201922020 - 20211
Reset filters

Settings

Author: NACAR, CEVDET ×

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    PublicationMetadata only
    Investigation of the Association Between Dopamine D1 Receptor Gene Polymorphisms and Essential Hypertension in a Group of Turkish Subjects
    (INFORMA HEALTHCARE, 2011) FAK, ALİ SERDAR; Orun, Oya; Nacar, Cevdet; Cabadak, Hulya; Tiber, Pinar Mega; Dogan, Yuksel; Guneysel, Ozlem; Fak, Ali Serdar; Kan, Beki
    Dopamine has been shown to influence blood pressure by regulating renal sodium excretion through direct interaction with the dopamine receptors, especially with the Dopamine D1 receptor (DRD1). To better understand the role of polymorphisms in those effects, we investigated the association between two polymorphic sites in the DRD1 promoter region (A-48G, G-94A) and essential hypertension in the Turkish population. The DRD1 variants were genotyped by restriction fragment length polymorphism (RFLP) analysis. A total of 205 unrelated individuals were enrolled in the study. We found that genotype distributions and allele frequencies of the control and hypertensive subjects were very similar and did not show any significant difference with respect to blood pressure (BP) and hypertension. Contribution of the gene variances in BP or hypertension by sex differences and dependence on body mass index (BMI) were also evaluated. Distribution of genotypes and allele frequencies were found to be in line with previous reports. However, increments detected in hypertensive subjects were far from being statistically significant.
  • No Thumbnail Available
    PublicationMetadata only
    The effect of acute topiramate administration on morphine withdrawal syndrome and brain-derived neurotrophic factor in central nervous system
    (2021-12-01) NACAR, CEVDET; CABADAK, HÜLYA; ÖZKULA S., YANANLI H. R. , JAFAROVA DEMİRKAPU M., NACAR C., CABADAK H.
  • No Thumbnail Available
    PublicationMetadata only
    The Role of G Protein beta 3 Subunit Polymorphisms C825T, C1429T, and G5177A in Turkish Subjects with Essential Hypertension
    (TAYLOR & FRANCIS INC, 2011) FAK, ALİ SERDAR; Cabadak, Hulya; Orun, Oya; Nacar, Cevdet; Dogan, Yuksel; Guneysel, Ozlem; Fak, Ali Serdar; Kan, Beki
    Hypertension is a multifactorial disorder that constitutes a major risk factor for the cardiovascular system. Heterotrimeric G-proteins, which couple receptors for diverse extracellular enzymes or ion channels, are correlated with disease mechanisms. Several studies have demonstrated an association between G protein polymorphisms and essential hypertension in some populations, although contradictive results also exist. In this study, we have investigated the potential role of the C825T, C1429T, and G5177A polymorphisms of the beta 3 subunit of G-proteins in essential hypertension in a group of Turkish subjects. Genomic DNA from 106 normotensive individuals (117.4 +/- 13.1, 75.2 +/- 10.5; systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, respectively) and 101 hypertensive subjects (152.3 +/- 18.0, 92.5 +/- 11.6; SBP and DBP levels, respectively) were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing methods for these polymorphisms. Allele frequencies of the polymorphisms were consistent with Hardy Weinberg equilibrium, except for the C825T polymorphism (chi(2) = 7.8). The frequencies of the 825T and 1429T variants were higher in hypertensive subjects compared to those of controls. Differences between hypertensives and controls were not statistically significant, though difference was very close to significance for C825T (p = 0.056 and 0.099 for 825T and 1429T, respectively). T allele frequency in overall population showed significant association with hypertension for C825T (0.0134). The prevalence of the 5177A-variant was very low and all subjects carrying it were heterozygotes in both groups.