Person: DEDE, FUAT
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DEDE
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FUAT
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Publication Metadata only Lesion detectability comparison of coincidence camera imaging and dedicated PET in the same patients.(2003-05-01) DEDE, FUAT; Narin Y., Canpolat N., Dede F., Urhan M., Bayhan H., Vardareli E.Publication Metadata only Cardiac troponin T for early detection of cardiotoxicity in breast cancer patients treated with epirubicin(DE GRUYTER POLAND SP ZOO, 2009) DEDE, FUAT; Erdim, Refik; Celiker, Aydin; Gemici, Goekmen; Tokay, Sena; Uelfer, Goezde; Dede, Fuat; Turhal, Serdar; Oktay, AhmetThe aim of the study was to investigate the role of cTnT for the prediction of long term cardiac dysfunction after epirubicin-containing adjuvant chemotherapy for breast cancer. The study group comprised of 45 patients (all female; mean age 48 +/- 8 years), treated with epirubicin-containing adjuvant chemotherapy for stage 2 and stage 3 breast cancer. Patients received either 4 cycles of cyclophosphamide plus epirubicin (90 mg/m(2)) (n=23; stage 2 breast cancer) or 6 cycles of cyclophosphamide plus epirubicin (75 mg/m(2)) plus fluorouracil (n=18; stage 3 breast cancer). Venous blood samples were drawn, before and 72 hours after, every cycle of chemotherapy for the measurement of cTnT. Cardiac assessment was carried out at baseline and 1 year after chemotherapy by clinical evaluation, electrocardiography, radio-nuclide ventriculography (RNV) and transthoracic echocardiography. All patients remained free of clinical heart failure during the study period. In 26 patients (63%), cTnT was elevated after chemotherapy. Mean left ventricular ejection fraction, assessed by RNV at baseline and one year after chemotherapy, were 61 +/- 8% and 56 +/- 7% (p < 0.0001). The sensitivity and specifity of cTnT for the detection of left ventricular systolic dysfunction at one year were 69% and 39% respectively. Echocardiographic examinations at baseline and one year after chemotherapy revealed a significant decrease in E/A ratio from 1.15 +/- 0.3 to 0.9 +/- 0.2 in cTnT positive patients, suggesting diastolic dysfunction. In conclusion, elevated serum cTnT levels after epirubicin-containing adjuvant chemotherapy for stage 2 and stage 3 breast cancer, predict future cardiac dysfunction with moderate sensitivity and poor specificity.Publication Metadata only Simple provocative maneuvers in renal transplant scintigraphy for detecting urine leak(SPRINGER, 2007) DEDE, FUAT; Dede, Fuat; Ones, Tunc; Caliskan, Billur; Civen, Huseyin; Erdil, Tanju Y.; Inanir, Sabahat; Tuglular, Zubeyde S.; Yegen, Cumhur; Akoglu, Emel; Turoglu, Halil T.Urine leak in the early postoperative period following renal transplantation is a serious complication requiring early identification and aggressive intervention, which significantly reduces the morbidity and mortality. Renal transplant scintigraphy is a noninvasive method to evaluate the perfusion and function of a transplanted kidney and urinary drainage including urine leak. Here, we reported two cases in which the standard transplant renogram failed to demonstrate urine leak. The cases were referred for a diethylenetriaminepentaacetic acid renogram following the transplantation to evaluate the cause of symptoms or elevated serum creatinine level. In both the cases, urine leak was successfully detected following simple maneuvers such as diuretic administration or Foley catheter irrigation. Renal transplant scintigraphy is an effective and safe technique and the use of these simple maneuvers can enhance the diagnostic sensitivity of the transplant renogram in the detection of urine leak.Publication Metadata only Screening of Parents and Siblings of Patients with Thyroid Dysgenesis by Thyroid Function Tests and Ultrasound(KARGER, 2008) BEREKET, ABDULLAH; Karakoc, Elif; Turan, Serap; Akpinar, Ihsan; Isguven, Pinar; Adal, Erdal; Haklar, Goncaguel; Dede, Fuat; Bereket, AbdullahAims: To investigate the frequency of thyroid dysgenesis (TD) in first-degree relatives of TD cases. Methods: 244 first-degree relatives of 82 TD cases were screened by thyroid ultrasound (USG), T-4, fT(4) and TSH. USG was also performed in 220 unrelated, age- and sex-matched healthy controls to obtain normative data for thyroid volumes. Results: Specific diagnoses of indexes were 35 ectopia, 22 athyreosis, 14 severe hypoplasia, 8 hypoplasia, and 3 hemiagenesis/asymmetric hypoplasia. In 5 of 77 families (6.5%), there were 2 cases with known symptomatic TD. A total of 10 cases made familial symptomatic TD ratio 12% (10/82) in our cohort. Screening of 244 asymptomatic family members did not reveal new cases with overt hypothyroidism. However, low thyroid volume in 15 and slightly elevated TSH in 6 family members and both in 1 family member were detected (7.4% for low thyroid volume, 3.2% for high TSH). Thus, the ratio of affected (symptomatic and asymptomatic) family members among families of TD cases was found to be 8.7%. Conclusions: 12% of TD cases are familial in our cohort. Screening of asymptomatic family members of TD revealed an additional 7.4% mild hypoplasia and 3.2% hyperthyrotropinemia without overt hypothyroidism which points out the importance of genetic factors in pathogenesis. Copyright (C) 2008 S. Karger AG, BaselPublication Open Access The role of F-18-FDG-PET in the detection of early cancers and precancerous polyps in colorectum(2009-11-01) DEDE, FUAT; Dede F.Publication Open Access Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects(AMER PHYSIOLOGICAL SOC, 2009-03) HAKLAR, GONCAGÜL; Enc, Feruze Yilmaz; Oenes, Tunc; Akin, H. Levent; Dede, Fuat; Turoglu, H. Turgut; Uelfer, Goerzde; Bekiroglu, Nural; Haklar, Goncaguel; Rehfeld, Jens F.; Holst, Jens J.; Ulusoy, Nefise B.; Imeryuez, NeseEnc, FY, Ones,T, Akin HL, Dede F, Turoglu HT, Ulfer G, Bekiroglu N, Haklar G, Rehfeld JF, Holst JJ, Ulusoy NB, Imeryuz N. Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects. Am J Physiol Gastrointest Liver Physiol 296: G482-G489, 2009. First published December 24, 2008; doi:10.1152/ajpgi.90209.2008.-Orlistat, an inhibitor of digestive lipases, is widely used for the treatment of obesity. Previous reports on the effect of orally ingested orlistat together with a meal on gastric emptying and secretion of gut peptides that modulate postprandial responses are controversial. We investigated the effect of ingested orlistat on gastric emptying and plasma responses of gut peptides in response to a solid mixed meal with a moderate energy load. In healthy subjects, gastric emptying was determined using scintigraphy and studies were performed without and with 120 mg of orlistat in pellet form in random order. Orlistat shortened t lag and t half and decreased the area under the gastric emptying curve. Orlistat significantly attenuated the secretion of glucose-dependent insulinotropic polypeptide (GIP) but did not alter the plasma responses of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and insulin. There was no peptide YY (PYY) response. Area under the curve of gastric emptying was positively correlated with integrated secretion of GIP (r = 0.786) in orlistat and was negatively correlated with integrated plasma response of GLP-1 (r = -0.75) in control experiments, implying that inhibition of fat absorption modifies determinants of gastric emptying of a meal. Orlistat administered similar to its use in obesity treatment accelerates gastric emptying of a solid mixed meal with a moderate energy load and profoundly attenuates release of GIP without appreciably altering plasma responses of CCK, GLP-1, and PP. Since GIP is being implemented in the development of obesity, its role in weight control attained by orlistat awaits further investigation.Publication Metadata only The clinical utility of 99(m)Tc-HMPAO SPECT in Fahr's disease(SPRINGER, 2008) GÜNAL, DİLEK; Ones, Tunc; Dede, Fuat; Gunal, Dilek; Ekinci, Gazanfer; Memis, Hatice; Erdil, Tanju Y.; Inanir, Sabahat; Turoglu, Halil T.Fahr's disease is a rare neurodegenerative syndrome, characterized by massive symmetrical intracerebral calcifications of the basal ganglia, dentate nuclei of the cerebellum, and the adjacent parenchyma. Computerized tomography (CT) is considerably more sensitive to detect these intracranial calcifications than other imaging modalities. The clinical, CT scan, and 99(m)Tc-D,L-hexamethylpropylene amine oxime (99(m)Tc-HMPAO) brain perfusion single-photon emission computerized tomography (SPECT) findings in a 42-year-old woman with Fahr's disease are reported, and the clinical utility of 99(m)Tc-HMPAO SPECT findings in Fahr's disease is discussed in this article. In conclusion, 99(m)Tc-HMPAO brain perfusion SPECT seems to be useful in the clinical approach to Fahr's disease, and may provide more specific and clinically relevant information when compared with anatomical imaging.Publication Metadata only Quantitative shunt imaging in the evaluation of therapeutic surgery in a patient with pulmonary arteriovenous malformation(ELSEVIER SCIENCE INC, 2008) DEDE, FUAT; Ones, Tunc; Dede, Fuat; Erdim, Refik; Erdil, Tanju Yusuf; Inanir, Sabahat; Yuksel, Mustafa; Turoglu, Halil TurgutA case of pulmonary arteriovenous malformation (PAVM) in a 32-year-old woman who underwent successful left upper lobectomy is presented. A whole-body technetium-99m-labeled macro-aggregated albumin scan was used to demonstrate intrapulmonary right-to-left shunt, and shunt fraction was calculated as 39%. The patient underwent a follow-up scan after the operation