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BOZKURT, SÜHEYLA

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BOZKURT

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SÜHEYLA

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2010 - 201923
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    Isolated metastasis of breast cancer to the pituitary gland
    (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2014) BOZKURT, SÜHEYLA; Eksi, Murat Sakir; Hasanov, Teyyub; Yilmaz, Baran; Akakin, Akin; Bayri, Yasar; Bozkurt, Suheyla Uyar; Kilic, Turker
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    The comparative effects of local anaesthetics on wound healing in rats: Bupivacaine vs Levobupivacaine
    (Ondokuz Mayis Universitesi, 2016) BOZKURT, SÜHEYLA; Atalay Y.O., Umuroglu T., Yagmur C., Gogus F.Y., Bozkurt S.
    The aim of this study is to investigate the effects of local anaesthetic agents (bupivacaine and levobupivacaine) on wound healing in rats. Wistar albino rats were randomly assigned to three groups (n=10 per group); the control group, the bupivacaine group, and the levobupivacaine group. An incision measuring 5 cm in length was made over the dorsum in all groups. The incisions were infiltrated with 3 ml of normal saline in the control group, 3 ml of 0.25%bupivacaine in the bupivacaine group, and 3 ml of 0.25%levobupivacaine in the levobupivacaine group. Histopathological examinations and tensile strength measurements were performed on tissue samples taken from the incision line 14 days after infiltration. Epidermal and dermal regeneration scores were significantly lower in the levobupivacaine group compared with the bupivacaine and control groups (p<0.05). Granulation tissue thickness, angiogenesis, and tensile strength measurements were not significantly different between groups. Even though incomplete epidermal and dermal regeneration scores were attained using levobupivacaine, both bupivacaine and levobupivacaine had no negative effects on the overall clinical wound-healing process. © 2016 OMU.
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    Mass-forming extramedullary hematopoiesis mimicking Hodgkin's lymphoma
    (MARMARA UNIV, FAC MEDICINE, 2019-01-31) BOZKURT, SÜHEYLA; Kombak, Faruk Erdem; Uyar Bozkurt, Suheyla; Ozgumus, Toluy; Kaygusuz Atagunduz, Isik
    Extramedullary hematopoiesis (EMH) refers to the proliferation of hematopoietic precursors outside the bone marrow. EMH often presents as a mass lesion in several areas of the body. In this report, we present a case misdiagnosed and explain the cause of the diagnostic error.
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    A Case of Acute Myeloid Leukemia (FAB M2) with Inversion 16 Who Presented with Pelvic Myeloid Sarcoma
    (2014) KOÇ, AHMET; Çakan, Mustafa; Koç, Ahmet; Cerit, Kıvılcım; Bozkurt, Süheyla; Ergelen, Rabia; Vural, Irmak
    Acute leukemias are the most common childhood cancer in all age groups. Acute myeloid leukemias (AML) constitute about 15-20% of acute leukemias. Fatigability, pallor, fever, and bleeding are the most common presenting symptoms of AML. Hepatosplenomegaly and lymphadenopathy are commonly encountered during physical examination. In rare instances eruptions due to skin involvement and localized tumor masses (myeloid sarcoma) may be found. Myeloid sarcoma is especially seen in AML-M2 subtype. By cytogenetic analysis, in AML-M2 subtype t(8;21) is often seen and it is more probable to find inversion 16 in AML-M4Eos subtype. Herein, we present a 15-year-old girl whose initial symptom was abdominal pain for three days and her pathological sign was a large abdominal mass which was verified by imaging studies and diagnosed as myeloid sarcoma by biopsy. On bone marrow examination, she had diagnosis of AML-M2 and by cytogenetic analysis inversion 16 was positive. She was treated with AML-BFM 2004 protocol and she is being followed up in remission on her ninth month of the maintenance therapy.
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    The histomorphological findings of kidneys after application of high dose and high-energy shock wave lithotripsy
    (POLISH UROLOGICAL ASSOC, 2015) BOZKURT, SÜHEYLA; Demir, Aslan; Turker, Polat; Bozkurt, Suheyla Uyar; Ilker, Yalcin Nazmi
    Introduction In this animal study, we reviewed the histomorphological findings in rabbit kidneys after a high number of high-energy shock wave applications and observed if there were any cumulative effects after repeated sessions. Material and methods We formed 2 groups, each consisting of 8 rabbits. Group 1 received 1 session and group 2 received 3 sessions of ESWL with a 7 day interval between sessions, consisting of 3500 beats to the left kidney and 5500 beats to the right kidney per session. The specimens of kidneys were examined histomorphologically after bilateral nephrectomy was performed. For statistical analysis, 4 groups of specimens were formed. The first and second groups received 1 session, 3500 and 5500 beats, respectively. The third and fourth groups received 3 sessions, at 3500 and 5500 beats per each session, respectively. The sections were evaluated under a light microscope to determine subcapsular thickening; subcapsular, intratubular and parenchymal hemorrhage; subcapsular, intersitital, perivascular and proximal ureteral fibrosis; paranchymal necrosis; tubular epithelial vacuolization; tubular atrophy; glomerular destruction and calcification. Results In histopathological examinations capsular thickening, subcapsular hematoma, tubuloepithelial vacuolisation, glomerular destruction, parenchymal hemorrhage, interstitial fibrosis, and perivascular fibrosis were observed in all groups. In statistical analysis, on the basis of perivascular fibrosis and tubular atrophy, there was a beats per session dependent increase of both. Conclusions The detrimental effects from ESWL are dose dependent but not cumulative for up to 3 sessions. Histopathological experimental animal studies will aid in understanding local and maybe, by means of these local effects, systemic effects.
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    PublicationOpen Access
    De novo myeloid sarcoma as a rare cause of small bowel obstruction: CT findings and histopathologic correlation
    (2019-12) ASLAN, BÜLENT; Aslan, Bülent; Tüney, Davut; Erçetin, Yiğit; Bozkurt, Süheyla Uyar; Uprak, Tevfik Kıvılcım
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    PublicationOpen Access
    CNon-Leukemic Granulocytic Sarcoma Presenting with Multiple Lymphadenopathies
    (GALENOS YAYINCILIK, 2017-05-11) BOZKURT, SÜHEYLA; Geduk, Ayfer; Demirsoy, Esra T.; Bozkurt, Suheyla U.; Gulbas, Zafer; Isgoren, Serkan
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    Gamma knife radiosurgery for cranial neurocytomas
    (SPRINGER, 2011) BOZKURT, SÜHEYLA; Genc, Ali; Bozkurt, Suheyla Uyar; Karabagli, Pinar; Seker, Askin; Bayri, Yasar; Konya, Deniz; Kilic, Turker
    Gamma-knife surgery may be an effective alternative for treatment of central neurocytomas owing to its relative safety compared with conventional radiotherapy. In this paper we present results of gamma-knife treatment (GKS) of residual or recurrent neurocytomas. Twenty-two patients (14 female, 8 male) with recurrent or residual neurocytomas who underwent GKS were included. Diagnosis was based on histological findings. The proliferative potential of the tumors was examined by immunostaining with MIB-1 antibody, which is specific for detection of Ki-67 antigen. Tumor volume was determined by using post-gadolinium magnetic resonance images. After GKS treatment, MR imaging was scheduled at three-month intervals in the first year, at six months intervals in the second year, and yearly thereafter. Histopathological diagnoses were: 18 cases of central neurocytomas, two liponeurocytomas, one cerebral neurocytoma and one cerebellar neurocytoma. The MIB1 labeling index (LI) varied from 0 to 5.7%. Marked reduction in tumor volume was seen in 15 patients. In six patients, the tumor volume remained unchanged, and progression was observed for one patient. No complications because of GKS were noted. Shrinking effect on tumor volume increased with increasing duration of follow-up. On the other hand, high MIB labeling index did not seem to have an effect on tumor response to GKS treatment. Findings of this study suggest that GKS is an effective and safe treatment alternative for residual or recurrent neurocytomas. However, its effectiveness should be confirmed with larger studies.
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    Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors
    (SPRINGER, 2018) DAĞÇINAR, ADNAN; Bozkurt, Suheyla Uyar; Dagcinar, A.; Tanrikulu, B.; Comunoglu, N.; Meydan, B. C.; Ozek, M.; Oz, B.
    Pediatric high-grade gliomas (pHGGs) constitute almost 15% of all childhood brain tumors. Recurrent mutations such as H3K27M mutation in H3F3A and HIST1H3B genes encoding histone H3 and its variants were identified in approximately 30% of pediatric glioblastomas. This study aimed to ascertain the morphological and molecular characteristics of pHGGs with H3K27M mutation. In total, 61 cases of pHGGs (anaplastic astrocytoma, 12; glioblastomas, 49) from four university hospitals were studied. The histomorphological features were examined and immunohistochemistry was performed to evaluate the mutation status of H3K27M, ATRX, IDH1, BRAF V600E, and p53 genes. The study comprised 25 females and 36 males (age range, 1-18 years) with a clinical follow-up of up to 108 months. From the total, 31 patients were positive for H3K27M mutation located in the midline, mostly in the pons and thalamus. H3K27M mutation was commonly associated with ATRX loss (32.3%) and p53 (74.2%) immunoreactivity with a co-expression rate of 25.8%. While IDH1 mutation was not detected in pHGGs with H3K27M mutation, BRAFV600E mutation was rarely observed. Among the various histomorphological features, increased number of mitosis, increased Ki-67 proliferation index, and palisading and geographical necrosis along with small cell patterns were significantly associated with the H3K27M wild-type tumors. Focal infarct-like necrosis and pilomyxoid morphology was significantly associated with these tumors. H3K27M mutation occurs exclusively in pHGGs arising from the midline and presents with varied histomorphological features ranging from low-grade pilomyxoid astrocytoma to highly pleomorphic glioblastoma along with ATRX loss and p53 mutations.
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    A case of mediastinal lymphangioma: endosonographic appearance
    (SPRINGER TOKYO, 2011) CEYHAN, BERRİN; Abul, Yasin; Eryuksel, Emel; Evman, Serdar; Karakurt, Sait; Batirel, Hasan; Yuksel, Mustafa; Kodalli, Nihat; Kalayci, Cem; Bozkurt, Suheyla; Ceyhan, Berrin
    Mediastinal lymphangioma is a rare, benign disease characterized by an abnormal proliferation of lymphatic vessels. Although a definitive diagnosis can be best made by surgical resection, computed tomography (CT) and magnetic resonance imaging (MRI) can be used as radiological methods to diagnose a pulmonary lymphangioma preoperatively. Endoscopic ultrasonography is a new method for visualizing pathological changes in the mediastum and may be used for preoperative diagnosis of a pulmonary lymphangioma, which is a rare example of a mediastinal disease.