Person: BOZKURT, SÜHEYLA
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
BOZKURT
First Name
SÜHEYLA
Name
38 results
Search Results
Now showing 1 - 10 of 38
Publication Metadata only Isolated metastasis of breast cancer to the pituitary gland(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2014) BOZKURT, SÜHEYLA; Eksi, Murat Sakir; Hasanov, Teyyub; Yilmaz, Baran; Akakin, Akin; Bayri, Yasar; Bozkurt, Suheyla Uyar; Kilic, TurkerPublication Metadata only The comparative effects of local anaesthetics on wound healing in rats: Bupivacaine vs Levobupivacaine(Ondokuz Mayis Universitesi, 2016) BOZKURT, SÜHEYLA; Atalay Y.O., Umuroglu T., Yagmur C., Gogus F.Y., Bozkurt S.The aim of this study is to investigate the effects of local anaesthetic agents (bupivacaine and levobupivacaine) on wound healing in rats. Wistar albino rats were randomly assigned to three groups (n=10 per group); the control group, the bupivacaine group, and the levobupivacaine group. An incision measuring 5 cm in length was made over the dorsum in all groups. The incisions were infiltrated with 3 ml of normal saline in the control group, 3 ml of 0.25%bupivacaine in the bupivacaine group, and 3 ml of 0.25%levobupivacaine in the levobupivacaine group. Histopathological examinations and tensile strength measurements were performed on tissue samples taken from the incision line 14 days after infiltration. Epidermal and dermal regeneration scores were significantly lower in the levobupivacaine group compared with the bupivacaine and control groups (p<0.05). Granulation tissue thickness, angiogenesis, and tensile strength measurements were not significantly different between groups. Even though incomplete epidermal and dermal regeneration scores were attained using levobupivacaine, both bupivacaine and levobupivacaine had no negative effects on the overall clinical wound-healing process. © 2016 OMU.Publication Metadata only Effects of parenteral fish-oil emulsion (Omegaven) on cutaneous wound healing in rats treated with dexamethasone(SAGE PUBLICATIONS INC, 2007) BOZKURT, SÜHEYLA; Gercek, Arzu; Yildirim, Ozlem; Konya, Deniz; Bozkurt, Suheyla; Ozgen, Serdar; Kilic, Turker; Sav, Aydin; Pamir, NecmettinBackground: The aim was to assess wound healing when parenteral fish-oil emulsion is given to rats receiving dexamethasone. Methods: For 5 days after skin wounding, group S (control; n = 7) received saline 1 mL/kg intraperitoneal (IP); group D (n = 7), dexamethasone 0.2 mg/kg IP; and group DO (n = 9), dexamethasone 0.2 mg/kg IP plus 1 mL/kg Omegaven (Fresenius Kabi, Austria). Wound specimens were assessed for hydroxyproline level, wound depth, histology (epidermal/dermal regeneration, granulation tissue thickness, and angiogenesis), and. expression of transforming growth factor-P (TGF-P) and platelet-derived growth factor-AA (PDGF-AA). Results: Compared with D and DO specimens, controls had higher hydroxyproline (p <.01), deeper wounds (p <.05), and better histologic scores (p <.01 angiogenesis; others p <.05). There were no significant differences between the group D and DO means for hydroxyproline level, wound depth, or histologic scores (p >.05 for all). Controls had higher TGF-P expression scores than the other groups (p <.01 for both) and a higher PDGF-AA expression score, than group DO (p <.01). Groups D and DO had statistically similar TGF-p scores, but group D had a higher PDGF-AA score (2.71 +/- 0.75 vs 1.55 +/- 0.72, respectively; p <.05). Conclusions: According to the parameters we studied, adding parenteral. omega-3 and omega-6 fatty acids to the nutrition regimen of rats treated with dexamethasone does not seem to have adverse effects on wound healing, and effects on wound healing may not need to be considered when determining if these agents should be supplemented in nutrition support regimens.Publication Metadata only Gastrointestinal kanal patolojisinde tuzaklar(Kongre Kitabevi, 2022-01-01) ÇELİKEL, ÇİĞDEM; BOZKURT, SÜHEYLA; ÇELİKEL Ç., GÜLLÜOĞLU M., BOZKURT S., DOĞANAVŞARGİL YAKUT B., SAKA B., GÖKSEL S., YAMAN B.Publication Metadata only The histomorphological findings of kidneys after application of high dose and high-energy shock wave lithotripsy(POLISH UROLOGICAL ASSOC, 2015) BOZKURT, SÜHEYLA; Demir, Aslan; Turker, Polat; Bozkurt, Suheyla Uyar; Ilker, Yalcin NazmiIntroduction In this animal study, we reviewed the histomorphological findings in rabbit kidneys after a high number of high-energy shock wave applications and observed if there were any cumulative effects after repeated sessions. Material and methods We formed 2 groups, each consisting of 8 rabbits. Group 1 received 1 session and group 2 received 3 sessions of ESWL with a 7 day interval between sessions, consisting of 3500 beats to the left kidney and 5500 beats to the right kidney per session. The specimens of kidneys were examined histomorphologically after bilateral nephrectomy was performed. For statistical analysis, 4 groups of specimens were formed. The first and second groups received 1 session, 3500 and 5500 beats, respectively. The third and fourth groups received 3 sessions, at 3500 and 5500 beats per each session, respectively. The sections were evaluated under a light microscope to determine subcapsular thickening; subcapsular, intratubular and parenchymal hemorrhage; subcapsular, intersitital, perivascular and proximal ureteral fibrosis; paranchymal necrosis; tubular epithelial vacuolization; tubular atrophy; glomerular destruction and calcification. Results In histopathological examinations capsular thickening, subcapsular hematoma, tubuloepithelial vacuolisation, glomerular destruction, parenchymal hemorrhage, interstitial fibrosis, and perivascular fibrosis were observed in all groups. In statistical analysis, on the basis of perivascular fibrosis and tubular atrophy, there was a beats per session dependent increase of both. Conclusions The detrimental effects from ESWL are dose dependent but not cumulative for up to 3 sessions. Histopathological experimental animal studies will aid in understanding local and maybe, by means of these local effects, systemic effects.Publication Metadata only Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13)(BLACKWELL PUBLISHING, 2008) BOZKURT, SÜHEYLA; Bozkurt, Suheyla Uyar; Berrak, Su Gulsun; Tugtepe, Halil; Canpolat, Cengiz; Palanduz, Sukru; Tecimer, TulayAcute megakaryoblastic leukemia is a relatively rare form of acute leukemia that has heterogeneous blast morphology and karyotypic abnormalities. An 8-month-old boy with a retroperitoneal mass was diagnosed as having acute megakaryoblastic leukemia that initially presented as small round cell tumor of childhood. Bone marrow aspiration showed syncytial groups of atypical medium sized cells with scant cytoplasm and fine nuclear chromatin. Retroperitoneal mass biopsy showed several lymph nodes with cohesive clusters of neoplastic cells that demonstrated expression of Factor VIII. Flow cytometric analysis of the second bone marrow aspiration showed CD 61 positivity. Karyotypic analysis of bone marrow cells showed a novel translocation, (1;5)(q21;p13).Publication Metadata only Challenges in the management of a 7 years old child with thyrotropin-secreting pituitary adenoma and the review of the literature(2023-01-01) KIRKGÖZ, TARIK; GÜRPINAR TOSUN, BUŞRA; ELTAN, MEHMET; HALİLOĞLU, BELMA; KAYGUSUZ, SARE BETÜL; SEVEN MENEVŞE, TUBA; BOZKURT, SÜHEYLA; ÖNEŞ, TUNÇ; GÜRAN, TÜLAY; DAĞÇINAR, ADNAN; BEREKET, ABDULLAH; DEMİRCİOĞLU, SERAP; KIRKGÖZ T., Abali S., Seker A., GÜRPINAR TOSUN B., ELTAN M., Helvacioglu D., HALİLOĞLU B., KAYGUSUZ S. B., Yavas Abali Z., SEVEN MENEVŞE T., et al.Introduction: Thyrotropin-producing pituitary adenoma (TSHoma) is a very rare disease, representing less than 1% of the pituitary tumours, present with elevated thyroid hormones and normal/high TSH concentrations. Case Presentation: A 7-year-old boy with nervousness was referred by his psychiatrist for elevated free T4, T3 and TSH levels. Initial evaluation revealed an elevated -subunit.Pituitary MRI demonstrated a macroadenoma. The patient underwent a trans-sphenoidal tumour resection (TSS) which showed positive immunohistochemical staining for TSH, growth hormone, and prolactin in tumoral tissue. Euthyroidism was achieved for one year after TSS, then, recurrence of tumour with elevated TSH and thyroid hormone levels necessitated a re-operation with TSS followed by gamma-knife radiosurgery. The euthyroid state was achieved and lasted for 2.5 years this time, but, due to the recurrence, medical treatment had been commenced with cabergoline and octreotide. Euthyroidism was maintained for the last 4 years on monthly octreotide treatment. A repeat MRI demonstrated no pituitary mass but a mass in the sphenoidal sinus had been detected. Removal of this mass by surgery did not achieve euthyroidism. 68Ga-DOTA-TATE PET/CT showed residual tissue extending from the pituitary region to the sphenoid sinus.The patient\"s bone age was advanced 2 years at diagnosis which became 4 years in one year after the diagnosis and remained so throughout follow-up, leading to a final height of -3.3 SDS below his target height at the age of 16 years. Conclusion: The diagnosis, treatment, and follow-up of TSHomas are challenging and short stature due to accelerated bone maturation is a complication of paediatric TSHomas.Publication Metadata only The effect of topical insulin application on the healing of acute tympanic membrane perforations: a histopathologic study(SPRINGER, 2007) BOZKURT, SÜHEYLA; Eken, Mehmet; Ates, Gunay; Sanla, Araf; Evren, Cenk; Bozkurt, SuheylaThe aim of the present study was to investigate the effects of insulin on the healing of acute traumatic tympanic membrane (TM) perforations by observing the duration of perforation closure clinically and by examining the TM thickness, fibroblastic reaction, neovascularization and collagenization histologically. In all, 24 adult healthy guinea pigs were used. TM perforations, about 2 mm in diameter were made in the pars tensa of each ear. The perforations in the right ears of the guinea pigs (study group) were treated with 1 IU of regular insulin (Humulin-R-(R) 100 IU/ml, Lilly) daily topically. The left ears of the guinea pigs (control group) were treated with saline solution daily. The treatments were continued until the each perforation closed. The animals were examined with otomicroscopy at first, third, fifth and seventh days. TM specimens were obtained after the animals were decapitated under deep anesthesia by an intraperitoneal injection of sodium pentobarbital (0.5 ml/100 g) 3 and 7 days after wounding. Histologically, the epithelial and mucosal layers were examined. Finger-like projections, the edema of the LP, neovascularization of LP, fibroblastic activity of LP, inflammatory cell presence of LP, collagenization ratios of LP were evaluated. In the study group; LP fibroblastic reaction positivity and LP collagenization positivity was significantly higher than the control group (P < 0.001 and P < 0.05). Topical insulin treatment may be more beneficial in the treatment of atrophic membrane, which is a sequel of perforation, when tried in various dosages and time intervals.Publication Metadata only Solitary fibrous tumor of the kidney(WILEY, 2007) KAYA, HANDAN; Bozkurt, Suheyla Uyar; Ahiskali, Rengin; Kaya, Handan; Demir, Aslan; Ilker, YalcinSolitary fibrous tumors are rare spindle cell neoplasms usually arising in the pleura. They have, however, also been reported at extrapleural locations. Solitary fibrous tumor (SFT) of the kidney is rare. Despite its rarity, histological diagnosis of solitary fibrous tumor is crucial to avoid misdiagnosis with other more aggressive tumors arising in the kidney. We report a solitary fibrous tumor of the left kidney that presented as a malignant tumor in a 51-year-old woman, and include clinical and radiographic findings. The tumor was well circumscribed and composed of spindle cells in a collagenous stroma. Immunohistochemistry showed reactivity for vimentin, CD 34, BCL-2 protein and CD99. Immunohistochemical stains for cytokeratin, S-100, desmin, alpha-smooth muscle actin and HMB-45 were negative. A diagnosis of SFT was made based on light microscopy and immunohistochemistry.Publication Metadata only Immunohistochemical expression of SPARC is correlated with recurrence, survival and malignant potential in meningiomas(WILEY, 2009) BOZKURT, SÜHEYLA; Bozkurt, Suheyla Uyar; Ayan, Erdogan; Bolukbasi, Fatihhan; Elmaci, Ilhan; Pamir, Necmettin; Sav, AydinMeningioma is a common neoplasm that constitutes almost 30% of all primary central nervous system tumors and is associated with inconsistent clinical outcomes. The extracellular matrix proteins play a crucial role in meningioma cell biology and are important in tumor cell invasion and in progression to malignancy. SPARC (secreted protein, acidic and rich in cysteine) (osteonectin) is a matricellular glycoprotein that regulates cell function by interacting with different extracellular matrix proteins. The aim of this study was to evaluate the expression of SPARC with proliferation index, p53 reactivity in WHO grade 1 (benign), grade 2 (atypical) and grade 3 (anaplastic) meningiomas and correlate with clinical features of the patients, including location of the tumor, recurrence of the tumor and survival of patients. We studied 111 meningiomas, 69 being benign, 34 being atypical and eight being anaplastic meningiomas of various histological types. Using immunohistochemical analysis, we evaluated the expression of SPARC, Ki-67 (MIB-1) and p53 in meningiomas. Immunohistochemical scores of SPARC were determined as the sum of frequency (0-3) and intensity (0-3) of immunolabeling of the tumor cells. A high immunohistochemical score (4-6) for SPARC was more frequent in atypical and in anaplastic meningiomas than in benign meningiomas (p < 0.01). MIB-1 proliferation index showed significant association between tumor grades in meningiomas (p < 0.01). At the end of a follow-up period of 47.53 +/- 25.04 months, 30 tumors recurred. A high SPARC expression was significantly associated with tumor recurrence (p = 0.02). The immunoreactivity of p53 protein and MIB-1 score were significantly higher in recurrent meningiomas than in non-recurrent meningiomas. The cumulative survival of patients with high SPARC expression was significantly lower than patients with low SPARC expression. The high SPARC expression scores were predominantly identified in meningothelial, fibrous and chordoid meningiomas; low SPARC expression scores were mostly spotted in secretory and psammomatous meningiomas. Evaluating SPARC expression might help assessing recurrence risk and survival estimation in meningiomas.