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ŞAHİN, ALİ

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ŞAHİN

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ALİ

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    Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers
    (ELSEVIER SCI LTD, 2021) ŞAHİN, ALİ; Hussein, Mohamed Ahmed Mohamady; Guler, Ece; Rayaman, Erkan; Cam, Muhammet Emin; Sahin, Ali; Grinholc, Mariusz; Mansuroglu, Demet Sezgin; Sahin, Yesim Muge; Gunduz, Oguzhan; Muhammed, Mamoun; El-Sherbiny, Ibrahim M.; Megahed, Mosaad
    Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer. The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.