Person: AKKOÇ, TUNÇ
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AKKOÇ
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TUNÇ
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Publication Metadata only Lymphocyte proliferation in common variable immunodeficiency (CVID) patients by carboxyfluorescein succinimidyl ester (CFSE)(2011-01-01) AKKOÇ, TUNÇ; ÖĞÜLÜR, İSMAİL; AYDINER, ELİF; BARIŞ, SAFA; Izgi A., AKKOÇ T., Ogulur I., Tevetoglu A., AYDINER E., BARIŞ S., Bahceciler N., Barlan I.Objective: Common variable immunodeficiency (CVID) is a heterogeneous disease in the group of predominantly antibody deficiencies, which is defined by hypogammaglobulinemia and normal or low level of B cells, and characterized by increased susceptibility to recurrent bacterial infections, autoimmune disorders, and malignancies. In this study, we aimed to investigate the proliferation of the B and T lymphocytes in patients with CVID.Publication Metadata only A novel approach in allergen-specific immunotherapy: Combination of sublingual and subcutaneous routes(MOSBY-ELSEVIER, 2011) ÖZEN, AHMET OĞUZHAN; Keles, Sevgi; Karakoc-Aydiner, Elif; Ozen, Ahmet; Izgi, Ayse Gul; Tevetoglu, Ayzer; Akkoc, Tunc; Bahceciler, Nerin N.; Barlan, IsilBackground: Subcutaneous allergen-specific immunotherapy (SIT) has an early onset of action, whereas repeated injections and safety concerns have limited its use in the pediatric age group. Meanwhile, the improved safety profile of the sublingual route has been accepted as an alternative despite its relatively late onset of action. Objective: We sought to improve the efficacy and safety of SIT with a combination of the subcutaneous route in the build-up phase and sublingual maintenance in comparison with the sublingual or subcutaneous routes alone. Methods: Fifty-one house dust mite-sensitized children with mild-to-moderate asthma were randomized into one of 4 groups to receive either (1) subcutaneous immunotherapy (SCIT), (2) sublingual immunotherapy (SLIT), (3) SCIT plus SLIT, or (4) pharmacotherapy. Clinical parameters were evaluated at baseline and months 1, 4, 12, and 18. Allergen-specific immunoglobulin levels and allergen-induced IL-5, IL-10, IL-13, IL-17, TGF-beta, and IFN-gamma levels were evaluated as well. Results: In the SCIT and SCIT plus SLIT groups, the number of asthma attacks and inhaled corticosteroid dosage decreased compared with baseline values at the months 4, 12, and 18 but only at month 12 in the SLIT group. The improvement in visual analog scores for rhinitis was significant only in the SCIT plus SLIT group. Increases in the levels of regulatory and T(H)1 cytokines were observed both in the SCIT and SLIT groups, with some differences in dynamics. Antigen-specific IgG(4) levels increased in the SCIT and SCIT plus SLIT groups but not in the SLIT group. Clinical symptom scores were correlated positively with IL-5 levels and negatively with antigen-specific IgG(4), IFN-gamma, and TGF-beta levels. Conclusion: Our novel regimen of immunotherapy, SCIT plus SLIT, appeared promising in that it successfully combined the advantages of the 2 alternatives: rapid onset and potency in SCIT and safety and avoidance of injections in SLIT. (J Allergy Clin Immunol 2011;128:808-15.)Publication Open Access Investigation of Th17 cell differentiation in immunodeficiencies associated with high IgE levels and/or autoimmunity(2011-01-01) AKKOÇ, TUNÇ; ÖĞÜLÜR, İSMAİL; AYDINER, ELİF; BARIŞ, SAFA; AKKOÇ T., Tevetoglu A., Ogulur I., Izgi A., AYDINER E., BARIŞ S., Bahceciler N., Barlan I.Objective: Hyper IgE Syndrome (HIES) and Common Variably Immunodeficiency (CVID) are immuno-deficiency diseases. HIES is characterized by recurrent skin abscesses, pneumonia, mucocutaneous fungal infections, eczama, eosinophilia and high serum IgE levels. CVID is characterized by recurrent bacterial infections in airways and gastrointestinal tract. In this study, differentiation of Th17 cells were aimed to be investigated in CVID and HIES patients.Publication Metadata only Neonatal BCG vaccination induces IL-10 production by CD4+CD25+T cells(WILEY, 2010) AYDINER, ELİF; Akkoc, Tunc; Aydogan, Metin; Yildiz, Aysegul; Karakoc-Aydiner, Elif; Eifan, Aarif; Keles, Sevgi; Akin, Mustafa; Kavuncuoglu, Sultan; Bahceciler, Nerin N.; Barlan, Isil B.To determine the optimal time of Bacillus Calmette-Guerin (BCG) vaccination for induction of Th1 immunity, we measured the interferon (IFN)-gamma and interleukin (IL)-10 secretion in purified protein derivative (PPD)-stimulated peripheral blood mononuclear cell (PBMC) cultures in newborns vaccinated at birth or 2nd month of life. Moreover, role of CD4+ CD25+ T cells was studied by depletion assay at 8th month. Nineteen term and healthy newborns were randomized into two groups: Group I composed of 10 newborns vaccinated with BCG at birth and the remaining 9 (group II) at 2nd month of life. PBMCs were isolated at birth, 2nd and 8th months of age, and PPD-stimulated IL-10, 5 and IFN-gamma secretion were assessed. The same measurements were repeated for IL-10 and IFN-gamma after the depletion of CD4+ CD25+ T cells at the 8th month. Children vaccinated at birth demonstrated higher PPD-stimulated IFN-gamma and IL-10 levels at 2 months of age when compared to non-vaccinated ones (p = 0.038 and p = 0.022, respectively), whereas at 8 months, no significant differences were detected between the two groups. Moreover, CD4+ CD25+-depleted T-cell cultures resulted in lower PPD-stimulated IL-10 levels in those vaccinated at birth when compared to non-depleted condition at the 8th month (p < 0.001). BCG at birth upregulated PPD-stimulated IFN-gamma secretion at the 2nd month and remained still detectable at 8 month after the vaccination, whereas those vaccinated at the 2nd month of life lacked that increase in IFN-gamma response at the same time-point. Furthermore, depletion assays suggest that CD4+ CD25+ T cells are involved in PPD-stimulated IL-10 secretion in response to BCG vaccination.