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AKKOÇ, TUNÇ

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Author: BARIŞ, SAFA × Subject: CVID ×

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    Lymphocyte proliferation in common variable immunodeficiency (CVID) patients by carboxyfluorescein succinimidyl ester (CFSE)
    (2011-01-01) AKKOÇ, TUNÇ; ÖĞÜLÜR, İSMAİL; AYDINER, ELİF; BARIŞ, SAFA; Izgi A., AKKOÇ T., Ogulur I., Tevetoglu A., AYDINER E., BARIŞ S., Bahceciler N., Barlan I.
    Objective: Common variable immunodeficiency (CVID) is a heterogeneous disease in the group of predominantly antibody deficiencies, which is defined by hypogammaglobulinemia and normal or low level of B cells, and characterized by increased susceptibility to recurrent bacterial infections, autoimmune disorders, and malignancies. In this study, we aimed to investigate the proliferation of the B and T lymphocytes in patients with CVID.
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    Investigation of Th17 cell differentiation in immunodeficiencies associated with high IgE levels and/or autoimmunity
    (2011-01-01) AKKOÇ, TUNÇ; ÖĞÜLÜR, İSMAİL; AYDINER, ELİF; BARIŞ, SAFA; AKKOÇ T., Tevetoglu A., Ogulur I., Izgi A., AYDINER E., BARIŞ S., Bahceciler N., Barlan I.
    Objective: Hyper IgE Syndrome (HIES) and Common Variably Immunodeficiency (CVID) are immuno-deficiency diseases. HIES is characterized by recurrent skin abscesses, pneumonia, mucocutaneous fungal infections, eczama, eosinophilia and high serum IgE levels. CVID is characterized by recurrent bacterial infections in airways and gastrointestinal tract. In this study, differentiation of Th17 cells were aimed to be investigated in CVID and HIES patients.