Person: KADİR, TANJU
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KADİR
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TANJU
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Publication Metadata only Er:YAG Laser Versus Systemic Metronidazole as an Adjunct to Nonsurgical Periodontal Therapy: A Clinical and Microbiological Study(MARY ANN LIEBERT INC, 2012) KADİR, TANJU; Yilmaz, Selcuk; Kut, Burak; Gursoy, Hare; Eren-Kuru, Bahar; Noyan, Ulku; Kadir, TanjuObjective: The objective of this randomized clinical trial was to describe the clinical and microbiological results obtained by treatment with Er:YAG laser and systemic metronidazole used as adjuncts to mechanical subgingival debridement in chronic periodontitis. Methods: Twenty-seven chronic periodontitis (CP) patients were randomly divided into three parallel groups each comprising nine individuals with at least four teeth having at least one approximal site with a probing depth (PD) of >= 5 mm and gingival index (GI) of >= 2 in each quadrant. Groups of patients received: (1) Scaling and root planing (SRP) + Er:YAG laser (10 hz, 30 mJ/pulse, 1 min per pocket, apico-coronal direction in parallel paths with 30 degree angle tips, under water irrigation), (2) SRP + systemic metronidazole, or (3) SRP alone. In all treatment groups, SRP was performed at 1 week intervals in two sessions. The microbiological and clinical effects of the treatments were evaluated after 90 days. Results: At the end of the experimental period, statistically significant improvements in plaque index, GI, PD and attachment level, as well as reductions in the number of total bacteria and proportions of obligately anaerobic microorganisms were observed within each group. Although intergroup comparisons revealed no significant microbiological differences, clinical parameters as attachment gain and PD reduction were found significantly higher in Group 1 compared with the other groups. Conclusions: Within its limits, this study demonstrated the possibility of better resolution of infection with combined SRP + Er: YAG laser treatment. However, microbiological results failed to demonstrate significant advantages of this combination in comparison with SRP alone or SRP + systemic metronidazole.Publication Metadata only Effect of oral antiseptic agents on phospholipase and proteinase enzymes of Candida albicans(PERGAMON-ELSEVIER SCIENCE LTD, 2016) GÜMRÜ TARÇIN, BİRSAY; Uygun-Can, Banu; Kadir, Tanju; Gumru, BirsayObjective: Candida-associated denture stomatitis is the most prevalent form of oral candida infections among the denture wearers. Generally, antiseptic oral rinses used in the treatment of these infections are considered as an adjunct or alternative antifungal treatment. Studies have suggested that the intraoral concentrations of antiseptics decrease substantially to the sub-therapeutic levels on account of the dynamics of the oral cavity. This condition yields the question about the minimum antiseptic concentration that effect the character or pathogenesis of Candida during treatment. The extracellular phospholipase and proteinase enzymes of Candida albicans are regarded to have a crucial role in the pathogenesis of human fungal infections. Therefore, the aim of this study was to investigate the effect of different sub-therapeutic concentrations of chlorhexidine gluconate, hexetidine and triclosan on the production of these enzymes by C. albicans strains isolated from 20 patients with denture stomatitis. Methods: Phospholipase test was done by using Sabouraud dextrose agar with egg yolk, proteinase test was done by using bovine serum albumin agar. Methods: Phospholipase test was done by using Sabouraud dextrose agar with egg yolk, proteinase test was done by using bovine serum albumin agar. Results: Exoenzyme production of 20 strains which were brief exposured to sub-therapeutic concentrations of three antiseptic agents decreased significantly compared with the strains that were not exposured with antiseptic values (p < 0.05). There was significant difference between the sub therapeutic concentrations of each of three antiseptics (p < 0.05). When the same concentrations of each antiseptic was compared, there were no significant differences between enzymatic activities (p > 0.05). Conclusions: The results of this study show that sub-therapeutic levels of each antiseptic may modulate candidal exoenzyme production, consequently suppressing pathogenicity of C albicans. (C) 2015 Elsevier Ltd. All rights reserved.Publication Metadata only Er:YAG Lasers Versus Ultrasonic and Hand Instruments in Periodontal Therapy: Clinical Parameters, Intracrevicular Micro-organism and Leukocyte Counts(MARY ANN LIEBERT, INC, 2012) KADİR, TANJU; Malali, Ezgi; Kadir, Tanju; Noyan, UlkuObjective: The aim of this study was to compare the clinical parameters and crevicular cell population, particularly leukocyte counts, changes after initial periodontal therapy with different instruments by a chairside laboratory technique, in severe periodontitis patients. Background data: Although scaling and root planing (SRP) with hand curettes or ultrasonic scalers may alter the subgingival microbial composition and improve clinical parameters, it is known that this effect decreases as the pocket depth (PD) increases. Material and methods: Thirty systemically healthy subjects with severe chronic periodontitis were randomly assigned to three groups (n = 10), and were treated either with hand curettes, ultrasonic scalers, or Er:YAG laser alone. Clinical measurements were made before and 90 days after treatment. A total of four subgingival plaque samples were collected from pockets with a PD 4-6 and >= 7 mm and were analyzed with a phase-contrast microscopy for microorganism proportions and leukocyte counts at baseline and 7 and 90 days after treatment. Results: From day 0 to day 90, clinical parameters were significantly improved in all groups (p < 0.01), but there were no significant differences among groups. Laboratory assessments revealed significant differences in all groups between baseline, day 7, and day 90. However, considering changes from day 7 to day 90, hand curettes were the most successful for maintaining the levels of micro-organisms and leukocytes. Conclusions: Although Er:YAG lasers are promising in treating periodontitis, the results of this study favor finishing SRP with hand curettes. Moreover, as there is a similar tendency between micro-organism and leukocyte count changes, leukocyte counts may be used as chairside marker to evaluate the efficacy of SRP.Publication Metadata only Investigation of bacteremia after toothbrushing in orthodontic patients(KOREAN ASSOC ORTHODONTISTS, 2009) KADİR, TANJU; Hussein, Emad Ahmad; Acar, Ahu; Dogan, Allev Aksoy; Kadir, Tanju; Caldemir, Seniz; Erverdi, NejatObjective: The aim of this study was to investigate the occurrence rate of bacteremia following toothbrushing with toothpastes composed of several antibacterial agents and compare the results with the conventional oral hygiene maintaining methods in orthodontic patients. Methods: This clinical study included 100 adult orthodontic patients who were divided into 4 groups. Each group comprised of 25 patients, wearing fixed orthodontic appliances. In the first group, bacteremia was assessed after toothbrushing without using any toothpaste. In the second group, a 0.2% chlorhexidine gluconate mouthrinse was used before brushing with no toothpaste. In the third group, subjects brushed with a commonly used toothpaste which did not include an additional antimicrobial agent. The fourth experimental group used toothpaste which included tea tree oil, clove oil, peppermint oil and bisabolol as antimicrobial elements. Pre- and post-brushing blood samples were obtained using a strict aseptic technique. All samples were microbiologically evaluated using blood culture bottles. Results: Toothbrushing in orthodontic patients yielded to an increase in the occurrence rate of bacteremia when using normal toothpaste or no toothpaste at all. Conclusions: The use of chlorhexidine mouthwash before toothbrushing, and brushing with antimicrobial toothpaste did not show a statistically significant difference in preventing the occurrence of bacteremia (p > 0.05). (Korean J Orthod 2009;39(3):177-184)Publication Metadata only Candida albicans adhesion on reinforced polymethylmethacrylate denture resin: effect of fibre architecture and exposure to saliva(WILEY, 2014) EVREN, BUKET; Akalin-Evren, Buket; Kulak-Ozkan, Yasemin; Ozcan, Mutlu; Kadir, TanjuBackground and objectives: Fiber-reinforced composites (FRC) are used to reinforce the prosthetic and restorative appliances. This may result in the exposure of the FRCs which may affect the adherence of microorganisms. This study evaluated the adhesion of Candida albicans to a denture base resin (N = 48), reinforced with E-glass FRCs with different architectures [unidirectional (n = 16) and woven (n = 16)], when exposed to either saliva or distilled water. Materials and methods: Specimens without FRC reinforcement served as control (n = 16). After fiber surfaces were exposed, half of the specimens (n = 8/per group) were treated with saliva, the other half was stored in distilled water prior to C. albicans adhesion. The adhered microorganisms were counted under an optical microscope and the data were analyzed. Results: When exposed to distilled water or saliva, specimens with unidirectional (5403.4 cells/cm(2) and 5013.4 cells/cm(2), respectively) (p = 0.202), woven fibers (4053.5 cells/cm(2) and 3726.6 cells/cm(2), respectively) (p = 0.283) and specimens without fibers (2250 cells/cm(2) and 2006.8 cells/cm(2), respectively) (p = 0.423) showed C. albicans adhesion, being not significant. In general, all the specimens exposed to saliva showed 3582.2 cells/cm(2) C. albicans adhesion, while specimens exposed to distilled water showed 3902 cells/cm(2) C. albicans adhesion, yet being not significant (p = 0.436). Regarding fiber type, C. albicans adhesion was significantly affected by the exposed FRC architecture with more favorable results for woven fibers (p < 0.001). Conclusion: Polymethylmethacrylate without FRCs collected less C. albicans. The presence of saliva seems to reduce the adhesion.Publication Metadata only Effect of galium arsenide diode laser on human periodontal disease: Aa microbiological and clinical study(WILEY, 2002) KADİR, TANJU; Yilmaz, S; Kuru, B; Kuru, L; Noyan, O; Argun, D; Kadir, TBackground and Objective: The present study is aimed to describe short-term results on selected microbiological and clinical parameters obtained by treatment with soft laser in conjunction with methylene blue and/or mechanical subgingival debridement in human periodontal disease. Study Design/Materials and Methods: Ten patients, in whom each dental quadrant was randomly designated to receive one of four types of treatment procedures, were included in the study. Groups of quadrants received: scaling/root planing (SRP); laser application (L); SRP combined with L (SRP/L); oral hygiene instructions (OHI). Four single rooted teeth (one in each quadrant), having an interproximal site with a probing depth of 4 mm mesio-buccally, were selected in each patient. The selected teeth were first assessed for microbiological (one site/tooth) and then for clinical variables (six sites/tooth). Supragingival irrigation with methylene blue was performed prior to laser application. The microbiological (proportions of obligate anaerobes) and clinical measurements (plaque and gingival indices, bleeding on probing, probing pocket depth) were evaluated over a period of 32 days. Results: Only the SRP/L and SRP groups provided significant reductions in the proportions of obligate anaerobes before and after treatments with no significant differences in between. Parallel to the microbiological changes, both SRP/L and SRP resulted in similar clinical improvements, whereas L alone revealed a limited effect similar to OHI. Conclusion: Within the limits of this study, methylene blue/soft laser therapy provided no additional microbiological and clinical benefits over conventional mechanical debridement. (C) 2002 Wiley-Liss, Inc.Publication Metadata only Effect of the diode laser on bacteremia associated with dental ultrasonic scaling: A clinical and microbiological study(MARY ANN LIEBERT INC, 2007) KADİR, TANJU; Assaf, Mohammad; Yilmaz, Selcuk; Kuru, Bahar; Ipci, Sebnem Dirikan; Noyun, Ulku; Kadir, TanjuObjective: The purpose of this study is to evaluate the potential use of diode lasers ( DLs) to reduce bacteremia associated with ultrasonic scaling ( US). Furthermore, the clinical efficacy of DLs as an adjunct to US in the treatment of gingivitis was investigated. Background Data: Recently, lasers have found new applications in dental practice. The benefits of the use of DLs as an adjunct to US have not yet been determined. Methods: Twenty-two gingivitis patients were treated using a split-mouth study design in which each side was randomly treated by US alone or DL followed by US ( DL + US). Blood samples were drawn just before and during US in each treatment step to detect induced bacteremia. Clinical parameters including plaque index, sulcus bleeding index, probing depth, and relative attachment level were recorded at baseline and 4 weeks postoperatively. Results: Bacteremia was detected in 15 patients ( 68%) after US alone, and in 8 patients following DL + US ( 36%). The reduction of the incidence of odontogenic bacteremia during US after the application of DL was statistically significant ( p < 0.05). Clinical signs improved eventually, with no significant differences between the two treatment regimens ( p > 0.05). Conclusions: Application of DL energy can reduce bacteria in gingival crevices which may reduce bacteremia following US. The use of DL did not show additional clinical influence on gingival healing after treatment of gingivitis with US.