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KADİR, TANJU

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KADİR

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TANJU

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2007 - 200912010 - 20141
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Subject: ADHERENCE ×

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    Candida albicans adhesion on reinforced polymethylmethacrylate denture resin: effect of fibre architecture and exposure to saliva
    (WILEY, 2014) EVREN, BUKET; Akalin-Evren, Buket; Kulak-Ozkan, Yasemin; Ozcan, Mutlu; Kadir, Tanju
    Background and objectives: Fiber-reinforced composites (FRC) are used to reinforce the prosthetic and restorative appliances. This may result in the exposure of the FRCs which may affect the adherence of microorganisms. This study evaluated the adhesion of Candida albicans to a denture base resin (N = 48), reinforced with E-glass FRCs with different architectures [unidirectional (n = 16) and woven (n = 16)], when exposed to either saliva or distilled water. Materials and methods: Specimens without FRC reinforcement served as control (n = 16). After fiber surfaces were exposed, half of the specimens (n = 8/per group) were treated with saliva, the other half was stored in distilled water prior to C. albicans adhesion. The adhered microorganisms were counted under an optical microscope and the data were analyzed. Results: When exposed to distilled water or saliva, specimens with unidirectional (5403.4 cells/cm(2) and 5013.4 cells/cm(2), respectively) (p = 0.202), woven fibers (4053.5 cells/cm(2) and 3726.6 cells/cm(2), respectively) (p = 0.283) and specimens without fibers (2250 cells/cm(2) and 2006.8 cells/cm(2), respectively) (p = 0.423) showed C. albicans adhesion, being not significant. In general, all the specimens exposed to saliva showed 3582.2 cells/cm(2) C. albicans adhesion, while specimens exposed to distilled water showed 3902 cells/cm(2) C. albicans adhesion, yet being not significant (p = 0.436). Regarding fiber type, C. albicans adhesion was significantly affected by the exposed FRC architecture with more favorable results for woven fibers (p < 0.001). Conclusion: Polymethylmethacrylate without FRCs collected less C. albicans. The presence of saliva seems to reduce the adhesion.
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    Phospholipase activity of Candida albicans isolates from patients with denture stomatitis: The influence of chlorhexidine gluconate on phospholipase production
    (PERGAMON-ELSEVIER SCIENCE LTD, 2007) KADİR, TANJU; Kadir, Tanju; Gumru, Birsay; Uygun-Can, Banu
    Background and objectives: The extracellular phospholipases of Candida albicans are considered to play a significant role in the pathogenesis of human infections. Therefore 23 clinical oral isolates of C. albicans from patients with denture stomatitis and 22 commensal oral isolates obtained from the palatal mucosa of healthy subjects were assayed for phospholipase activity. It is generally accepted that chlorhexidine gluconate is an appropriate adjunct or an alternative to antimycotic therapy in the management of oral candidiasis. However, the intraoral concentrations of this antiseptic fluctuate considerably due to the dynamics of the oral cavity. So the second main objective of this study was to investigate the effect of brief exposure (30 min) to two sub-therapeutic concentrations (0.002% and 0.0012%) of chlorhexidine gluconate on the value of phospholipase production (Pz) of C. albicans. Method: An in vitro phospholipase production was done by plate assay method using an egg yolk-agar medium. Results: No significant differences were found in the number of C. albicans isolates producing phospholipase between two groups. However, the mean value of Pz produced by the isolates from patients with denture stomatitis was significantly (p < 0.05) higher than the commensals. Exposure of the isolates to 0.002% and 0.0012% chlorhexidine led to a significant (p < 0.001 and p < 0.01, respectively) reduction in the amount of phospholipase. Conclusion: The results of this study imply that sub-therapeutic levels of chlorhexidine may modulate candidal phospholipase activity, thereby suppressing pathogenicity of C. albicans. (c) 2006 Elsevier Ltd. All rights reserved.