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KADİR, TANJU

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KADİR

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TANJU

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1996 - 199922020 - 20232
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Subject: CLINICAL MEDICINE ×

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Now showing 1 - 4 of 4
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    The relation of microbiologic data to aspartate aminotransferase enzyme activity in gingival crevicular fluid
    (1996-01-01) YILMAZ, SEBİHA NİHAL; KADİR, TANJU; Kuru B., Noyan U., YILMAZ S. N., KADİR T., Acar O., Büget E.
    Gingival crevicular fluid (GCF), reflects the immune and inflammatory reactions and is itself a location for specific host-microbe interactions that lead to periodontal diseases. Aspartate aminotransferase (AST) is one of the components of GCF that is released as a result of cell death. In this study, 40 periodontal sites in 10 early onset periodontitis patients before and after nonsurgical periodontal therapy, with and without local metronidazole administration, were first examined for the AST enzyme levels in GCF and then evaluated for microbiological and clinical variables. In each patient, 4 sites (one site/quadrant) with a probing depth of > or = 5 mm were selected and treated with separate treatment protocols. Certain microbial species including Prevotella intermedia, Porphyromonas gingivalis, and Actinobacillus actinomycetemcomitans(A. a.) were found more often and/or in higher levels in AST active sites (36/40 first measurement--9/36 second measurement), while other species (Streptococcus and Actinomyces) were found more often and/or in higher levels in AST inactive sites (4/40 first measurement--8/36 second measurement). Eight post-treatment AST active sites revealed 1.5 mm of attachment loss, whereas 8 post-treatment AST inactive sites showed 1.37 mm of attachment gain. AST activity and microbiological-clinical data presenting such an agreement suggests that, AST level assessment would be beneficial as an adjunctive method alongside other clinical criteria, in guiding the clinician in periodontal treatment.
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    Dental caries and Cariostat test in preschool children
    (1997-01-01) KADİR, TANJU; Akyüz S., KADİR T., Erdem H.
    The aim of this study was to investigate the caries status and susceptibility of children in preschool age. Sixty one children ages between 3 to 5 years (mean age 4.38 +/- 0.71) participated in this study. Caries status was assessed according to WHO criteria, and caries susceptibility by using the Cariostat test. The mean df-t was found to be 2.28 +/- 0.71 (df-s 6.26 +/- 11.92) and 31 children were caries-free. Cariostat scores were 1.75, 2.00, 2.16 in the 3, 4, and 5 year age groups respectively. There were no significant differences in caries status or Cariostat scores between boys and girls. The df-t for the 5 year age group was significantly higher than that for the 3 year age groups (p 2.0).
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    PublicationOpen Access
    Bifidobacterium animalis subsp. lactis as adjunct to non-surgical periodontal treatment in periodontitis: a randomized controlled clinical trial
    (2023-01-01) KURU, LEYLA; KADİR, TANJU; KÖSE, KEMAL NACİ; Özener H. Ö., KURU L., KADİR T., Kuru B.
    © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Objectives: The purpose of this study is to investigate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yogurt as an adjunct to non-surgical periodontal treatment in periodontitis patients. Materials and methods: This is a prospective randomized controlled clinical study registered with NCT05408364 under clinical trial registration. Thirty periodontitis patients were divided into 2 groups at random. As adjunctive to supra and subgingival instrumentation, the test group consumed Bifidobacterium animalis subsp. lactis DN-173010 containing yogurt while the control group consumed natural yogurt, once daily for 28 days. The plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 28th day, and 3rd month. Microbiological analysis was performed using culture method by obtaining subgingival plaque samples from 2 periodontal sites with 4≤PD≤6 mm at the same time points. Results: The inter-group comparisons of PI, GI, and BOP as well as the changes between the measurement time points were statistically significant in favor of the test group. There were no significant differences in terms of PD and CAL changes between the study groups at all times (∆baseline–28 days, ∆baseline–3 months) (p>0.05). The number of patients presenting subgingival Bifidobacterium species was significantly greater in the test group than the control group at the 28th day (p<0.05). Conclusions: The administration of probiotics has shown beneficial effects, albeit limited, on clinical and microbiological outcomes in the management of periodontitis patients. Clinical relevance: Daily consumption of probiotic yogurt may be supportive for supra and subgingival instrumentation.
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    PublicationOpen Access
    Alzheimer hastalığı ile periodontal hastalıklar arasında bir ilişki olabilir mi
    (2020-10-01) KADİR, TANJU; OLUKPINAR GENÇ B., KADİR T.
    Alzheimer hastalığı (AH), antimikrobiyal peptit olarak bilinen βamiloid birikimi ve anormal şekilde fosforile tau proteinlerinden oluşan nörofibriler yumakların varlığı ile karakterize nöroinflamatuar ve nörodejeneratif bir hastalık olarak tanımlanır. Periodontal hastalığın patogenezinde rol oynayan Porphyromonas gingivalis (P. gingivalis) AH ile ilişkili önemli bakteriyel patojenden biri olarak kabul edilmiştir. Ağız boşluğunda bulunan bu bakteriye ait metabolik yan ürünlerinin ağız boşluğunun ötesinde bağışıklık sistemini aktive edebildiği böylece sistemik koşulların gelişimini teşvik edebildiği gözlenmiştir. Artan sayıda yapılan çalışmalar P. gingivalis'in beyin kolonizasyonunun inflamatuar ve dejeneratif durumu birbirine bağlayabileceğini bildirmiştir. AH'li kişilerin beyinlerinden alınan otopsi örneklerinde ve beyin omurilik sıvılarında P. gingivalis infiltrasyonunun varlığı tespit edilmiştir. P. gingivalis tarafından üretilen proteaz sınıfı olan gingipainlerin AH'li bireylerin beyinlerinden alınan örneklerde nöronlar, tau yumakları ve β-amiloid ile ilişkili olduğu bulunmuştur. Yerleşik beyin enfeksiyonları olan farelere oral yoldan verilen gingipain inhibitörlerinin beyindeki P. gingivalis DNA bolluğunu ve bakteri enfeksiyonunun nörotoksik etkilerini azalttığı bildirilmiştir. Dolayısıyla gingipain inhibisyonu hem periodontitis hem de AH'nın tedavisine potansiyel bir yaklaşım sağlayabildiği düşünülmüştür. Bu derlemenin amacı, periodontal hastalık ile Alzheimer hastalığı ve demans arasında nedensel bir ilişki olasılığını değerlendirmek ve literatürlerdeki daha fazla araştırma gerektiren temel boşlukları belirlemek olmuştur.