Person:
KOYUNCUOĞLU, TÜRKAN

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

KOYUNCUOĞLU

First Name

TÜRKAN

Name

Filters

20232
Reset filters

Settings

Has files: true × Subject: Clinical Medicine (MED) ×

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    PublicationOpen Access
    Impact of valproate and levetiracetam exposure on GAERS behavior during pregnancy
    (2023-09-01) TURGAN AŞIK, ZEHRA NUR; KOYUNCUOĞLU, TÜRKAN; KASIMAY ÇAKIR, ÖZGÜR; YAVUZ M., Kantarcı B. C., Şanlı A., Gavaş Ş., TURGAN AŞIK Z. N., KOYUNCUOĞLU T., KASIMAY Ö., ONAT F.
    Objective: Valproate (VPA) and levetiracetam (LEV) are frequently prescribed for the management of idiopathic generalized seizures; however, their well-documented teratogenic effects raise concerns when administered to pregnant epileptic patients. This study aimed to assess the impact of VPA and LEV exposure during pregnancy on Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Methods: Female GAERS rats were categorized into three groups: saline-treated (n=6), VPA-treated (200 mg/kg, n=4), and LEV-treated (50 mg/kg, n=6). Intraperitoneal injections were initiated from mating start and continued until partition. Locomotor activity and anxiety-like behavior were evaluated using open-field and hole-board tests for the VPA-treated and VPA-and LEV-treated groups; respectively. These tests were conducted both before and during pregnancy. Results: Across all groups, open-field testing demonstrated a tendency toward reduced locomotor activity parameters compared with pre-pregnancy, with VPA treatment showing significance (p<0.05). The hole-board test indicated a trend toward decreased rearing and hole exploration, coupled with increased freezing behavior in the saline-and VPA-treated groups. The LEV-treated group showed an elevation in freezing behavior and a decline in hole exploration. Conclusion: Although minimal effects on anxiety-like behaviors were noted in anti-seizure drug-treated rats, subtle tendencies were evident in the hole-board test. VPA and LEV administration resulted in depressive parameters in the locomotor activity test. These findings emphasize the need for caution when prescribing and using VPA and the LEV during pregnancy in terms of maternal behavior and mood.
  • Thumbnail Image
    PublicationOpen Access
    Anti-inflammatory, antioxidant and neuroprotective effects of niacin on mild traumatic brain injury in rats
    (2023-01-01) KOYUNCUOĞLU, TÜRKAN; AKAKIN, DİLEK; ERZİK, CAN; YÜKSEL, MERAL; YEGEN, BERRAK; Ozaydin D., Bektasoglu P. K., Koyuncuoglu T., Ozkaya S. C., Koroglu A. K., AKAKIN D., ERZİK C., YÜKSEL M., YEGEN B., Gurer B.
    AIM: To study the effects of niacin, a water-soluble vitamin, on inflammation, oxidative stress and apoptotic processes observed after mild traumatic brain injury (TBI). MATERIAL and METHODS: A total of 25 Wistar albino male rats were randomly divided into control (n=9), TBI + Placebo group (n=9), TBI + niacin (500 mg/kg; n=7) groups. Mild TBI was performed under anesthesia by dropping a 300 g weight from a height of 1 meter onto the skull. Behavioral tests were applied before and 24 hours after TBI. Luminol and lucigenin levels and tissue cytokine levels were measured. Histopathological damage was scored in brain tissue. RESULTS: After mild TBI, luminol and lucigenin levels were increased (p<0.001), and their levels were decreased with niacin treatment (p<0.01-p<0.001). An increased score was obtained with trauma in the tail suspension test (p<0.01), showing depressive behavior. The number of entries to arms in Y-maze test were decreased in TBI group compared to pre-traumatic values (p<0.01), while discrimination (p<0.05) and recognition indices (p<0.05) in object recognition test were decreased with trauma, but niacin treatment did not change the outcomes in behavioral tests. Levels of the anti-inflammatory cytokine IL-10 were decreased with trauma, and increased with niacin treatment (p<0.05). The histological damage score was increased with trauma (p<0.001), and decreased with niacin treatment in the cortex (p<0.05), and hippocampal dentate gyrus region (p<0.01). CONCLUSION: Niacin treatment after mild TBI inhibited trauma-induced production of reactive oxygen derivatives and elevated the anti-inflammatory IL-10 level. Niacin treatment ameliorated the histopathologically evident damage.