Person:
TATAR, ESRA

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

TATAR

First Name

ESRA

Name

Filters

20201
Reset filters

Settings

Start date: 2020 × Has files: false ×

Search Results

Now showing 1 - 1 of 1
  • No Thumbnail Available
    PublicationMetadata only
    Fabrication and characterisation studies of cyclodextrin-based nanosponges for sulfamethoxazole delivery
    (SPRINGER, 2020) TATAR, ESRA; Yasayan, Gokcen; Sert, Betul Satiroglu; Tatar, Esra; Kucukguzel, Ilkay
    beta-Cyclodextrin based nanosponges have been synthesized in three molar ratios, and characterized by phase solubility studies, Fourier-transform infrared spectroscopy, matrix-assisted laser desorption/ionization time of flight mass spectrometry, and scanning electron microscopy. Following characterization studies, a model anti-bacterial agent, sulfamethoxazole, has been loaded within the nanosponges, and in vitro drug release studies were carried out. According to results, nanosponges below similar to 100 nm diameter were obtained with a characteristic sponge-like morphology. Phase solubility studies demonstrated that beta-cyclodextrin nanosponges improve solubility of the drug up to 30-fold. These results suggest that nanosponges could improve the bioavailability of drugs by conducing them to reach desired plasma concentrations for therapeutic effect. [GRAPHICS] .