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KUTLUĞ AĞAÇKIRAN, SEDA

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KUTLUĞ AĞAÇKIRAN

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Author: ALİBAZ ÖNER, FATMA ×

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    PublicationOpen Access
    Earlier and more aggressive treatment with biologics may prevent relapses and further new organ involvement in Behçet's disease
    (2023-03-01) BOZKURT, TUĞÇE; KARABACAK, MURAT; KUTLUĞ AĞAÇKIRAN, SEDA; DİRESKENELİ, RAFİ HANER; ALİBAZ ÖNER, FATMA; BOZKURT T., KARABACAK M., Karatas H., KUTLUĞ AĞAÇKIRAN S., Ergun T., DİRESKENELİ R. H., ALİBAZ ÖNER F.
    Objective: Immunosuppressives (IS) are the choice of treatment for major organ involvement in Behçet\"s disease (BD). In this study, we aimed to investigate the relapse rate and new major organ development in BD under ISs during long-term follow-up. Methods: The files of 1114 BD patients followed in Marmara University Behçet\"s Clinic were analyzed retrospectively. Patients with a follow-up less than 6 months were excluded. Conventional IS and biologic treatment courses were compared. ‘Events under IS’ were defined as a relapse of the same organ and/or new major organ development in patients receiving ISs. Results: Among 806 patients included in the final analysis (male: 56%, age at diagnosis: 29 (23–35) years, median follow-up time: 68 (33–106) months). Major organ involvement was present in 232 (50.5%) patients at diagnosis, and 227 (49.5%) developed new major organ involvement during follow-up. Major organ involvement developed earlier in males (p = 0.012) and in patients with a first-degree relative history of BD (p = 0.066). ISs were given mostly for major organ involvement (86.8%, n = 440). Overall, 36% of the patients had a relapse or new major organ involvement under ISs (relapse: 30.9%, new major organ involvement: 11.6%.) ‘Events under IS’ (35.5% vs 20.8%, p = 0.004), and relapses (29.3% vs 13.9%, p = 0.001) were more common with conventional ISs compared to biologics. Conclusion: Any major event under ISs was less common with biologics compared to conventional ISs in patients with BD. These results suggest that earlier and more aggressive treatment may be an option in BD patients who had the highest risk for severe disease course.
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    Myocardial involvement in Behcet's disease may be higher in patients with Neuro-Behcet's disease: a speckle tracking echocardiographic study
    (TAYLOR & FRANCIS LTD) ÖZBEN SADIÇ, BESTE; Sunbul, Murat; Midi, Ipek Gursoy; Agackiran, Seda Kutlug; Engin, Esin; Ucem, Selen; Alibaz-Oner, Fatma; Sayar, Nurten; Direskeneli, Haner; Sadic, Beste Ozben
    Background Behcet's disease (BD) may present with life threating complications including neurological and cardiovascular involvement. Neuro-Behcet's disease (NBD) is one of the most important causes of morbidity and mortality in patients with BD. The aim of the present study is to investigate whether patients with NBD are different than BD patients with other manifestations in terms of subclinical myocardial dysfunction. Methods Forty patients with NBD (23 female, mean age: 42.4 +/- 9.4 years), 40 patients with BD (9 female, mean age: 39.7 +/- 9.0 years) and 40 controls (20 male, mean age: 41.8 +/- 6.5 years) were consecutively included in the study. All subjects underwent a transthoracic echocardiography for evaluation of left ventricular (LV) and atrial (LA) functions with two-dimensional (2D) speckle tracking echocardiography (STE). Results Baseline characteristics, clinical data, LV dimensions, systolic and diastolic functions were all in normal range among the groups. LV global longitudinal strain (LV-GLS) was significantly lower in patients with NBD and BD patients without neurologic involvement compared to controls. LA conduit strain was significantly lower in patients with NBD compared to controls. Patients with both parenchymal NBD and vascular NBD manifestations had significantly lower LV-GLS and LA conduit strain compared to controls. Linear regression analysis demonstrated that among cardiovascular risk factors only presence of NBD was the independent predictor of LV-GLS. Conclusions BD is associated with impaired LV and LA functions. LV-GLS and LA conduit strains of the patients with NBD were lower. NBD was an independent predictor of LV-GLS, suggesting a link between neurological manifestations and cardiac dysfunction in BD patients.
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    PublicationOpen Access
    Re: Risk of hbv reactivation in hbsag negative and antihbc igg positive patients receiving biologic therapy
    (2023-03-01) KANİ, HALUK TARIK; KARABACAK, MURAT; CÖMERT ÖZER, ELİF; ABACAR, KEREM YİĞİT; KUTLUĞ AĞAÇKIRAN, SEDA; SEVİK, GİZEM; ALİBAZ ÖNER, FATMA; İNANÇ, GÜZİDE NEVSUN; ATAGÜNDÜZ, MEHMET PAMİR; ÖZEN ALAHDAB, YEŞİM; DİRESKENELİ, RAFİ HANER; ATUĞ, ÖZLEN; Ergenç İ., KANİ H. T., KARABACAK M., CÖMERT ÖZER E., Mehdiyev S., Jafarov F., ABACAR K. Y., KUTLUĞ AĞAÇKIRAN S., SEVİK G., Aslan R., et al.