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BALCAN, MEHMET BARAN

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BALCAN

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MEHMET BARAN

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2017 - 20182
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Subject: ADULTS ×

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    PublicationOpen Access
    Procalcitonin-Guided Antibiotic Treatment in Lower Respiratory Tract Infections
    (GALENOS YAYINCILIK, 2018-08-06) CEYHAN, BERRİN; Balci, Merih Kalamanoglu; Balcan, Baran; Yildizeli, Sehnaz Olgun; Ceyhan, Berrin
    Objective: Procalcitonin (PCT), C-reactive protein (CRP), and leukocyte count are important host response biomarkers to determine the presence of infection. The aim of the present study was to evaluate the usefulness of PCT with other markers in lower respiratory tract infections. Methods: A total of 78 patients with community-acquired pneumonia (CAP), chronic obstructive pulmonary disease (COPD) exacerbations, and healthy controls were evaluated. Baseline serum levels of PCT and CRP and leukocyte counts were assessed and repeated on day 7 of antibiotic treatment. Results: Procalcitonin levels and absolute neutrophil counts (ANCs) were higher in the CAP and COPD groups than in the control group. In the CAP and COPD exacerbation groups, the leukocyte count, ANC, and CRP and PCT levels decreased on day 7 of the treatment (p<0.001). In the CAP group, the baseline PCT levels were correlated with leukocyte counts (r=0.495, p<0.005), ANCs (r=0.426, p<0.019), and CRP levels (r=0.515, p<0.004). In receiver operating characteristic curve analysis, PCT threshold >0.12 ng/mL had a sensitivity of 70.4% and specificity of 68.7%, and CRP threshold >22.9 mg/L had a sensitivity of 85.2% and specificity of 75.0%. Conclusion: Procalcitonin is a useful marker to determine the initiation of antibiotic therapy and can also be used to cease the treatment.
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    Association Between Severe Vitamin D Deficiency, Lung Function and Asthma Control
    (ELSEVIER ESPANA SLU, 2017) CEYHAN, BERRİN; Beyhan-Sagmen, Seda; Baykan, Ozgur; Balcan, Baran; Ceyhan, Berrin
    Introduction: To examine the relationship between severe vitamin D deficiency, asthma control, and pulmonary function in Turkish adults with asthma. Methods: One hundred six asthmatic patients underwent pulmonary function tests skin prick test, peripheral blood eosinophil counts, IgE, body mass index and vitamin D levels were determined. Patients were divided into 2 subgroups according to vitamin D levels (vitamin D level < 10 ng/ml and vitamin D level >= 10 ng/ml). Asthma control tests were performed. Results: The mean age of subgroup I (vitamin D level < 10) was 37 +/- 10 and the mean age of subgroup II (vitamin D level >= 10 ng/ml) was 34 +/- 8. Sixty-six percent of patients had severe vitamin D deficiency (vitamin D level < 10 ng/m1). There was a significant trend towards lower absolute FEV1 (L) values in patients with lower vitamin D levels (P=.001). Asthma control test scores were significantly low in the severe deficiency group than the other group (P=.02). There were a greater number of patients with uncontrolled asthma (asthma control test scores < 20) in the severe vitamin D deficiency group (P=.040). Patients with severe vitamin D deficiency had a higher usage of inhaled corticosteroids than the group without severe vitamin D deficiency (P=.015). There was a significant trend towards lower absolute FEV1 (L) (P=.005, r =.272) values in patients with lower vitamin D levels. Vitamin D levels were inversely related with body mass index (P=.046). Conclusion: The incidence of severe vitamin D deficiency was high in adult Turkish asthmatics. In addition,lower vitamin D levels were associated with poor asthma control and decreased pulmonary function.(C) 2016 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.