Person: EROL, BÜLENT
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EROL
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BÜLENT
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Publication Metadata only Staged management of infection with adjustable spacers after megaprosthesis implantation in primary sarcoma patients(2023-03-01) ŞİRİN, EVRİM; AKGÜLLE, AHMET HAMDİ; EROL, BÜLENT; ŞİRİN E., Sofulu O., Baysal O., AKGÜLLE A. H., EROL B.BackgroundWhile periprosthetic joint infection has always been a significant concern for orthopaedic surgeons, the rate of infection is five to ten times higher after tumor prosthesis implantation. With the growing use of mega-implants, the number of these infections has also increased. We aimed to investigate the results of our patients with a primary malignant musculoskeletal tumor, who underwent two-stage revision surgery for an infected mega-prosthesis. We also presented the emerging complicatons and required soft tissue reconstruction procedures.MethodsThe study included 32 primary bone and soft tissue sarcoma patients who underwent a two-stage revision procedure for infection. After a rigorous bone and soft tissue debridement procedure at the first stage, antibiotic-loaded bone cement was wrapped around a cloverleaf type intramedullary nail and inserted into the forming gap. After a minimum of 6 weeks of antibiotic therapy, depending on patients\" clinical signs and serum infection markers, the reimplantation stage was undertaken.ResultsThe mean oncologic follow-up period was 28 months (range 5-96 months). During this period, 11 patients died because of non-infection related causes, 12 patients were alive with their disease, whereas 9 patients were totally free of their oncologic condition. The infection was eradicated in all survivors except one patient, where a high-level transfemoral amputation became necessary.ConclusionPeriprosthetic infection after tumor proshesis implantation in cancer patients can be managed with same principles as conventional arthroplaty procedures, taking care that they are immunocompromised and vulnerable patients and their bone stock loss is significant which makes surgical options more challenging.Publication Metadata only Case report: Reconstruction of an intercalary defect with bone transport after resection of Ewing's sarcoma(LIPPINCOTT WILLIAMS & WILKINS, 2005) EROL, BÜLENT; Dormans, JP; Ofluoglu, O; Erol, B; Moroz, L; Davidson, RSWe report a 13-year-old girl with Ewing's sarcoma of the tibia who was treated with multiagent chemotherapy, followed by local control tumor surgery consisting of wide resection of the tumor and bone transport with distraction osteogenesis for reconstruction. The bone defect created by resection was 13 cm long and was replaced by bone transport using a monolateral external fixator. Evaluation of the resected specimen revealed wide tumor-free margins with 100% chemonecrosis. A planned Harmon-type autogenous bone grafting between the middle and proximal segments of the tibia (docking site) was done primarily after docking occurred, and a solid union was obtained by 23 months after resection. The bone healing index (treatment index) was 54 days/1 cm distraction, which is indicative of slow healing. Clinical evaluation of the affected extremity using the Musculoskeletal Tumor Society rating system revealed 80% normal functional capability. Indications for bone transport in reconstruction of bone defects created by wide resection of bone sarcomas are discussed. In retrospect, we have concerns regarding the suitability of this technique in the setting of diaphyseal sarcoma reconstruction in patients with Ewing's sarcoma who require aggressive and intense multiagent chemotherapy.Publication Metadata only Lower back pain and mass in a 13-year-old girl(LIPPINCOTT WILLIAMS & WILKINS, 2005) EROL, BÜLENT; Ricchetti, ET; Erol, B; Stern, J; Russo, P; States, L; Dormans, JPPublication Metadata only Knee pain in a 13-year-old boy(LIPPINCOTT WILLIAMS & WILKINS, 2003) EROL, BÜLENT; Erol, B; Lou, J; States, L; Pawel, BR; Dormans, JPPublication Metadata only The impact of pathological fractures on surgery, morbidity, functional and oncological outcomes in patients with primary bone sarcomas(ELSEVIER SCI LTD, 2021) EROL, BÜLENT; Saglam, Fevzi; Baysal, Ozgur; Sofulu, Omer; Baykan, Said Erkam; Erol, BulentBackground Although rare, pathological fractures may occur in primary bone sarcomas. There have been studies reporting that such patients have a poorer prognosis than those without a pathological fracture. This study investigates the impact of pathological fractures on surgery, morbidity, functional and oncological outcomes in patients with primary bone sarcomas. Patients and methods A retrospective analysis of 568 patients with primary bone sarcomas, treated between 2005 and 2019, was performed. The study included 41 patients with a pathological fracture and 51 control patients who did not have a pathological fracture. A multivariate Cox regression analysis was used to investigate the impact of pathological fractures and further independent variables on amount of intraoperative bleeding, duration of surgery, number of muscles and major neurovascular structures included in resection, tumor volume, surgical volume, Musculoskeletal Tumor Society (MSTS) functional score, postoperative complication rate, and local recurrence, distant metastasis, and survival rates. Results There were 36 (39%) female and 56 (61%) male patients. No statistically significant difference was noted in tumor volume, tumor/surgical volume percentage, number of major neurovascular structures included in resection, postoperative complication rate, and local recurrence, distant metastasis, and survival rates between the two groups (p > 0.05). A significantly higher amount of intraoperative bleeding and number of transfused blood components, a longer duration of surgery, and a higher amount surgical volume and number of resected muscles were detected in Group 1 compared to Group 2 (p=0.0 01, p =0.002, p= 0.007, p= 0.007, p < 0.001, respectively). The MSTS functional scores were lower in patients with a pathological fracture than in those without a pathological fracture (p=0.001). Conclusion We conclude that a pathological fracture through a primary bone sarcoma has no adverse effect on prognostic factors such as local recurrence, distant metastasis, and survival. However, pathological fractures increase the amount of intraoperative bleeding and surgical volume and result in a longer surgery, in addition to decreased functional outcomes. (C) 2021 Elsevier Ltd. All rights reserved.