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OKTAY, NİHAL ŞEHKAR

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NİHAL ŞEHKAR

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2021 - 20233
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End date: 2024 × Subject: Clinical Medicine (MED) ×

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Now showing 1 - 3 of 3
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    A guide to vitamins and their effects on diseases
    (Cambridge University Press, Cambridge (MA), USA , 2023-01-01) OKTAY, NİHAL ŞEHKAR; Oktay N. Ş.
    This book provides a contemporary, comprehensive and general review of vitamins and the role of vitamins in diseases. In the first part of the book, readers will be informed about fat-soluble and water-soluble vitamins, vitamin-like substances, how they work in the body, their absorption, storage, transport, their recommended daily allowances, deficiencies and toxicity. In the second part, readers will discover how vitamins affect several diseases, and learn about their mechanism of action in diseases. The second part will also explore vitamin related minerals such as calcium, phosphorus, magnesium, potassium, copper and zinc. The book is unique in that it reveals the mechanism of action of each vitamin in relation to conditions such as the metabolism, autoimmune diseases, degenerative systems, infectious diseases, and aging. This book serves as a brief but beneficial guide for academic institutions, health professionals, practitioners, medical and dentistry students, nutritionists and pharmacists.
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    Biochemical investigation of methotreaxate-induced oxidative stress on liver tissue
    (2023-11-23) OKTAY, NİHAL ŞEHKAR; Savaş Ş., Oktay N. Ş.
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    PublicationOpen Access
    Preliminary findings of the distribution of alpha-2-adrenergic receptor (ADRA2A) rs1800544 polymorphisms in kickboxing players
    (2021-12-01) TACAL ASLAN, BESTE; OKTAY, NİHAL ŞEHKAR; ULUCAN, KORKUT; Eken B. F., Savcı A. A., Polat T., Yılmaz Ö. Ö., Silar C., TACAL ASLAN B., OKTAY N. Ş., ULUCAN K.
    Objective: Adrenergic receptors play an important role in providing neurotransmitter release from the sympathetic nervous system and adrenergic neurons. The rs1800544 polymorphism in 3’-untranslated region of Alpha-2-Adrenergic Receptor (ADRA2A) is if caused by C>G tranversion at position –1291. In this study, we objective to analyze the rs1800544 distribution in kickboxing players. Methods: A total of 12 male players and 101 sedentary individuals (as a control group) participated in the study. Following DNA isolation, rs1800544 polymorphism of ADRA2A gene was determined by real-time polymerase chain reaction (Rt-PCR). Statistical analysis was carried out by chi-square test. Results: CC, CG and GG genotypes and percentages for rs1800544 polymorphism were analyzed as 5 (41,7%), 4 (33,3%) and 3 (25%), respectively. C allele was counted as 14 (58,3%) and G allele as 10 (41,7%). In the control group CC, CG and GG were found as 34 (33,6%), 53 (52,5%), 14(13,9%), respectively. C allele was counted as 121 (60%) and G allele as 81 (40%). When we compare athletes and controls in the terms of genotypes, we detected no statistically significant difference (p>0,3940). For the allele comparison, we detected no significant difference between groups (p>0,0871). Conclusion: Determination of gene combinations in athletes is of great importance for determination of the effect of genetic factors in athletic performance. In our cohort, CC genotype was more frequently found, and C allele was also higher in players. We think that the effect of ADR2A2 gene on athletic performance might be determined more clearly by the fact that this study is an example of similar studies involving higher numbers of subjects.