Person: OYSU, ÇAĞATAY
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OYSU
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ÇAĞATAY
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Publication Open Access Developing a new model for rhinosinusitis: Animal experiment(2023-09-01) OYSU, ÇAĞATAY; Çaypınar Eser B., Canpolat M. S., Güneş P. G., İrvem ., Zer Toros S., Şahin Yılmaz A., Oysu Ç.Aim: To develop a new model of acute bacterial rhinosinusitis. Method: We divided guinea pigs into four groups in this study. In the primary group of guinea pigs, right nasal cavities of the animals were vaccinated with Streptococcus pneumoniae suspension. In the second group, sponge strips saturated with sterile saline into the right nasal cavities of animals. In the third group, sponge strips saturated with Streptococcus pneumoniae suspension in the right nasal cavities of animals. The fourth group was control group, which was exposed to no intervention. After 7, 14, 28, 35 days from interventions, intranasal cultures were obtained, computed tomography (CT) scans were imaged from all of the guinea pigs, and two randomly selected guinea pigs that were detected as having rhinosinusitis radiologically were killed every week. The sinuses and nasal specimens of sacrificed guinea pigs were prepared for histopathological investigation. Results: Radiological and histopathological examinations of nasal samples were performed to observe the severity of the inflammatory reaction. Acute bacterial rhinosinusitis was induced in all groups of subject animals except the control group. More severe inflammation was seen in the third group of subject animals compared to the first and second groups. No inflammatory reaction was found in the control group. We also evaluated the normal flora of guinea pigs. Conclusion: The guinea pig is certainly a true model for developing rhinosinusitis. Guinea pigs should be considered as an alternative model for further potential studies of genetics and inflammation, even though surgical manipulation is limited.Publication Metadata only Diagnostic Features and Risk Factors for Childhood Thyroid Cancers(2022-09-01) ŞAHİN, PINAR; GÜRPINAR TOSUN, BUŞRA; YUMUŞAKHUYLU, ALİ CEMAL; GÜRAN, TÜLAY; HALİLOĞLU, BELMA; OYSU, ÇAĞATAY; DEMİRCİOĞLU, SERAP; BEREKET, ABDULLAH; ŞAHİN P., GÜRPINAR TOSUN B., YUMUŞAKHUYLU A. C. , GÜRAN T., Helvacioglu D., Abali Z. Y. , HALİLOĞLU B., OYSU Ç., BEREKET A., DEMİRCİOĞLU S.Publication Open Access Relationship of PPARG overexpression with prognostic parameters in papillary thyroid carcinoma(2022-02-01) ASYA, ORHAN; YUMUŞAKHUYLU, ALİ CEMAL; BAĞCI ÇULÇİ, PELİN; ŞAHİN, AKIN; OYSU, ÇAĞATAY; KAYA, HANDAN; ASYA O., YUMUŞAKHUYLU A. C., BAĞCI ÇULÇİ P., KAYA H., Gonen A., Gundogdu Y., Muradov T., ŞAHİN A., OYSU Ç.Objectives. PAX8/PPARG chromosomal rearrangement is frequently seen in thyroid cancer, and PPARG overexpression has been shown in the follicular variant of papillary thyroid carcinoma, but not in papillary thyroid carcinoma other than the follicular variant. The main aim of this study was to investigate the frequency of PPARG overexpression among papillary thyroid carcinoma and if there were any variants of papillary thyroid carcinoma with PPARG overexpression other than the follicular variant. Methods. Immunohistochemical analysis of PPARG overexpression was performed using a PPARG monoclonal antibody in a series of 111 paraffin-embedded blocks of thyroid tumours. Of the patients in our study, 100 were diagnosed with papillary thyroid carcinoma, 9 with follicular adenoma and 2 with follicular carcinoma. Results. PPARG staining was detected in 19 of the 111 cases. Sixteen patients with PPARG overexpression had papillary thyroid carcinoma and 3 had follicular adenoma. Conclusion. PPARG overexpression was detected mainly in follicular-variant papillary thyroid carcinoma. Vascular invasion, lymphatic invasion, thyroid capsule invasion and lymph node positivity were lower in patients with PPARG overexpression.Publication Open Access Propeller diffusion weighted imaging for diagnosis of cholesteatoma in comparison with surgical and histopathological results: Emphasis on false positivity and false negativity(2023-05-01) SEMİZ OYSU, ASLIHAN; OYSU, ÇAĞATAY; Semiz-Oysu A., OYSU Ç., Kulali F., Bukte Y.PurposeTo investigate the role of non-echo planar diffusion weighted imaging (DWI) using \"periodically rotated overlapping parallel lines with enhanced reconstruction\" (PROPELLER) sequence for the diagnosis of cholesteatoma compared to surgical and histopathological results in an attempt to determine the factors causing false negative and false positive diagnoses.MethodsPatients who had PROPELLER DWI before ear surgery were retrospectively reviewed. The presence of a lesion with diffusion restriction on PROPELLER DWI was accepted as positive for cholesteatoma, and the results were compared to the intraoperative and histopathological findings.ResultsA total of 112 ears in 109 patients were reviewed. On PROPELLER DWI, a lesion with diffusion restriction was found in 101 (90.2%) ears, while in 11 (9.8%) of the patients, no diffusion restriction was found. Surgery and histopathological analysis revealed a cholesteatoma in 100 (89.3%) ears, while in 12 (10.7%) ears, no cholesteatoma was found surgically. There were 96 (85.7%) true positives, 7 (6.2%) true negatives, 5 (4.5%) false positives and 4 (3.6%) false negatives. The accuracy, sensitivity, specificity, positive predictive and negative predictive values of non-echo planar DWI were calculated to be 91.96%, 96%, 58.33%, 95.05%, and 63.64%, respectively.ConclusionNon-echo planar DWI using PROPELLER sequence has high accuracy, sensitivity and positive predictive value and can be used for the detection of cholesteatoma. The external auditory canal, postoperative ears and small lesions should be evaluated with caution to avoid false results.Publication Open Access Effect of education and social anxiety on acoustic, perceptual and aerodynamic parameters of adult females(2022-12-01) OYSU, ÇAĞATAY; Duymaz Y. K., Surmeli M., Erzincan E., Deveci I., Canakci H., Yilmaz A. A. S., OYSU Ç.In this study, we hypothesized that social anxiety disorder would be more common in women with lower education levels and that this could have a negative effect on acoustic parameters. A total of eighty-eight (88) healthy female volunteers were enrolled into the study. These volunteers were divided into two groups, which were categorized as those with graduation from elementary school or below (Group A, n = 42) and those with graduation from high school or above (Group B, n = 46). Personal anxiety and avoidance for all participants were evaluated using The Liebowitz Social Anxiety Scale. All subjects also underwent acoustic and aerodynamic voice analysis for evaluation of their objective voice quality and function. Additionally, the GRBAS scale was used for perceptual analysis. Social anxiety scores were higher in group A than group B (p 0.05). In this study, social anxiety and education has been shown to have an effect on voice in women. As the level of education increases, social anxiety decreases, and both maximum phonation time and fundamental frequency increase.Publication Open Access Evaluation of the auditory system in autistic children using evoked otoacoustic emissions and a contralateral suppression test(2022-02-01) OYSU, ÇAĞATAY; Aslan E., Guzel I., Caypinar B., Samanci B., Oysu Ç.In this study, we evaluated the cochlea, medial olivocochlear system, and brainstem function in autistic children using evoked otoacoustic emissions (OAEs) and a noninvasive contralateral suppression (CLS) test. In total, we included 21 autistic children with normal hearing (study group) and 11 healthy children (control group). Transient-evoked OAEs (TEOAEs) and CLS of TEOAE were evaluated in the left and right ears of all patients. In a silent room, spontaneous, transient, and dP ILO292 were evaluated. The mean age of the study and control group was 9.1 years (range: 6-13 and 6-12 years, respectively). For the study group, there was no statistically significant difference between the OAE and CLS values of the right ear (P > .05). However, for the left ears, OAE values were statistically significantly higher than the CLS values (P < .05). In the control group, the OAE values of both ears were statistically significantly higher than the CLS values (P < .05). In autistic children with normal hearing, the medial olivocochlear system functions more effectively in the right ear than the left ear. Asymmetry between the ears is likely responsible for the peripheral auditory lateralization and independence in auditory function between the left and right ears.Publication Open Access A single-center multidisciplinary study analyzing thyroid nodule risk stratification by comparing the thyroid imaging reporting and data system (TI-RADS) and American thyroid association (ATA) risk of malignancy for thyroid nodules(2022-01-01) ASYA, ORHAN; YUMUŞAKHUYLU, ALİ CEMAL; ENVER, NECATİ; İNCAZ, SEFA; GÜNDOĞMUŞ, CEMAL AYDIN; ERGELEN, RABİA; BAĞCI ÇULÇİ, PELİN; OYSU, ÇAĞATAY; ASYA O., YUMUŞAKHUYLU A. C. , ENVER N., Gündoğdu Y., Abuzaid G., İNCAZ S., GÜNDOĞMUŞ C. A. , ERGELEN R., Bağcı P., OYSU Ç.© 2022 Elsevier LtdObjectives: The thyroid imaging reporting and data system (TI-RADS) and 2015 American Thyroid Association (ATA) guidelines are two well-known risk stratification systems for classifying thyroid nodules based on cancer risk. This study aims to evaluate the diagnostic efficacy of these two systems in predicting malignancy in patients undergoing thyroid surgery. Methods: We studied data on 120 individuals who were scheduled to undergo surgery for benign or malignant nodular diseases of the thyroid gland between October 2017 and October 2019. The TI-RADS category and ultrasound pattern based on ATA guidelines were assigned to dominant thyroid nodule categories by two experienced radiologists blinded to patients’ previous thyroid ultrasonography and fine-needle aspiration biopsy results. A pathologist with experience in thyroid diseases blinded to patients’ sonographic and clinical data reviewed the thyroidectomy specimens. Results: A total of 120 patients, 88 women and 32 men, were included in our study. Final histopathological results were as follows: 50% (n=60) papillary thyroid carcinoma, 36.6% (n=44) benign nodular thyroid diseases, 4.1% (n=5) follicular adenoma, 2.5% (n=3) hurtle cell adenoma, 1.7% (n=2) follicular thyroid carcinoma, 1.7% (n=2) medullary thyroid carcinoma, 1.7% (n=2) hurtle cell carcinoma, and 1.7% (n=2) follicular tumor of uncertain malignancy potential. The sensitivity, specificity, positive predictive value, and negative predictive value for TI-RADS were 80%, 56%, 72%, and 67%, respectively, and that for ATA were 80%, 64%, 76%, and 69%, respectively. Conclusion: The TI-RADS and ATA showed similar rates of sensitivity, specificity, NPV, and PPV. Our observed risk of malignancy was higher than expected for the ACR TI-RADS 3–5 categories and the very low, low, and intermediate suspicion risk strata in the ATA guidelines. We found no difference between observed and expected malignancy risk for the ACR TI-RADS 2’s and ATA\"s high suspicion categories.