Person:
DULUNDU, ENDER

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

DULUNDU

First Name

ENDER

Name

Filters

20111
Reset filters

Settings

Has files: true × Subject: INFLAMMATION ×

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    PublicationOpen Access
    Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats
    (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2011) DULUNDU, ENDER; Bulut, Nuriye Esen; Ozkan, Erkan; Ekince, Osman; Dulundu, Ender; Topaloglu, Umit; Sehirli, Ahmet Ozer; Ercan, Feriha; Sener, Goksel
    BACKGROUND The present study aimed to determine the effects of alpha lipoic acid (ALA) on blood and tissue biochemical parameters, as well as tissue histopathology, in an experimental rat model of cerulein-induced acute pancreatitis (AP). METHODS Three groups consisting of eight rats each were used, as follows: Group I. controls; Group 2, cerulein-induced pancreatitis group treated with saline; and Group 3, cerulein-induced pancreatitis group treated with ALA. AP was induced by intraperitoneal administration of cerulein (20 mu g/kg) 4 times at I-hour intervals. The animals were decapitated 12 hours after the last dose of cerulein. Blood amylase, lipase, interleukin (IL)-1 beta, and tumor necrosis factor (TNF)-alpha levels, pancreas tissue glutathione (GSH) and malondialdehyde (MDA) levels, as well as myeloperoxidase (MPO) and Na+-K+-ATPase activity were measured. Pancreatic tissue samples were also evaluated histopathologically under a light microscope. RESULTS While plasma amylase, lipase, IL-1 beta, and TNF-alpha levels, and tissue MDA and MPO levels significantly increased in rats with cerulean-induced AP, tissue GSH and Na+-K+-ATPase activity significantly reduced. These changes were reversed and improved with ALA treatment. CONCLUSION Our findings suggest that ALA may significantly reduce morbidity and mortality by preventing organ dysfunction induced by free radicals in the pancreas.