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KARAALP, ATİLA

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KARAALP

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ATİLA

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    PublicationOpen Access
    COLCHICINE USE DURING PREGNANCY: CASE REPORTS
    (BMJ PUBLISHING GROUP, 2019-06) KARAALP, ATİLA; Duman, Nesrin Caglayan; Karabacak, Murat; Oglu, Medine Gulcebi Idriz; Inanc, Nevsun; Asik, Zehra Nur Turgan; Atagunduz, Pamir; Ozkula, Songul; Gulhan, Rezzan; Goren, Zafer; Onat, Filiz; Direskeneli, Haner; Karaalp, Atila
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    PublicationOpen Access
    Impact of a short postgraduate course in rational pharmacotherapy for general practitioners: Rational pharmacotherapy course: impact on GPs
    (2003-11-14) AKICI, AHMET; Akici, Ahmet; Kalaça, Sibel; Ugurlu, M. Ümit; Karaalp, Atila; Çali, Şanda; Oktay, Şule
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    PublicationOpen Access
    Association of PD-1 and PDL-1 gene polymorphisms with colorectal cancer risk and prognosis
    (2022-03-01) KARAALP, ATİLA; SÜSLEYİCİ, BELGİN; Cevik M., Namal E., Iner-Koksal U., Dinc-Sener N., KARAALP A., Ciftci C., SÜSLEYİCİ B.
    Background Programmed Cell Death-1 (PD-1) together with Programmed Death Ligand 1 (PDL-1) have crucial roles in anti-tumor immune response, cancer susceptibility and prognosis. Since PD-1 and PDL-1 have been considered as important genetic risk factors in cancer development and their functions can be affected by polymorphic sites, we investigated the effects of PD-1 rs2227981, rs2227982, rs36084323 and PDL-1 rs2282055, rs822336 gene polymorphisms on colorectal cancer (CRC) risk and prognosis in Turkish subjects. Methods and results Our study group consisted of 5-FU or Capacitabine prescribed CRC diagnosed patients and healthy controls. Genotype analyses of PD1 and PDL-1 polymorphisms were performed with Agena MassARRAY platform. rs36084323 CT genotype frequency was found to be higher in controls compared to cases (p C polymorphism might be useful in predicting CRC prognosis. PDL-1 rs2282055 T > G polymorphism might be useful in predicting both CRC risk and prognosis. Further studies should be conducted in larger and different populations to clear the roles of PD-1 and PDL-1 polymorphisms in CRC risk and prognosis.
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    PublicationOpen Access
    EVALUATIONS OF ANTIRHEUMATIC DRUGS AT PRECONCEPTIONAL, PREGNANCY AND POSTPARTUM PERIODS OF RA PATIENTS' IN A UNIVERSITY HOSPITAL; PRELIMINARY RESULTS
    (BMJ PUBLISHING GROUP, 2019-06) KARAALP, ATİLA; Duman, Nesrin Caglayan; Karaalp, Atila; Inanc, Nevsun