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OKUYAN, BETÜL

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Eczacılık Fakültesi

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OKUYAN

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BETÜL

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Open Access
Eczacının Yer Aldığı Antimikrobiyal Yönetim_x000D_ Programlarının Klinik ve Ekonomik Sonuçları
(2019) OKUYAN, BETÜL; Mesut SANCAR;Zeynep SAYIN;Sercan CANKATAR;Nazan DALGIÇ;BETÜL OKUYAN
Antimikrobiyal yönetim programı, antimikrobiyal ilaç tedavisinin iyileştirilmesine yönelik düzenlemeleri kapsayan, multidisipliner bir yaklaşımdır. Son yıllarda, özellikle antibiyotik direncinin azaltılmasında önemli yeri olduğu kabul edilen antimikrobiyal yönetim programlarında öncelikle doktor, klinikeczacı ve klinik mikrobiyologlardan oluşan bir ekibe yer verilmesi önerilmektedir. Eczacının, antimikrobiyallerin uygulama zamanı ve veriliş sıklığı konusundaki danışmanlığının yanı sıra, bu ilaçlara bağlı ilaçilaç, ilaç-besin ve ilaç-hastalık etkileşimleri, ilaç istenmeyen etkileri gibi alanlarda da katkı yapabilecekleribilinmektedir. Bu çalışmada, enfeksiyon hastalıklarının kontrolünde ve tedavisinde önemli yeri olan antimikrobiyal yönetim programlarında sağlık ekibinin önemli bir parçası olarak bulunan eczacıların olası etkilerinin klinik ve ekonomik boyutlarının irdelenmesi amaçlanmıştır. Bu amaca yönelik olarak, Pubmedveri tabanında 01.01.2010 - 31.12.2015 yıllarını kapsayan 5 yıllık bir literatür taraması yapılmıştır. Uygunsözcükler kullanılarak doğrudan eczacı katkısını araştıran çalışmalar seçilmiştir. Bu çalışmanın amacınauygun olarak 34 orijinal makale incelenmiştir. Bu çalışmalarda, eczacı müdahalelerinin yer aldığı antimikrobiyal yönetim programlarının pozitif klinik ve ekonomik sonuçları olduğu görülmüştür. Eczacının buyönetim programlarında antimikrobiyallerin daha akılcı kullanılmasına, antibiyotiklerin daha az sayıda reçete edilmesine, direnç oranlarının azaltılmasına, daha fazla klinik değerlendirme yapılmasına, ilaç dozunun ayarlanmasına, antimikrobiyal ilacın kesilmesi veya başlanması süreçlerine, parenteral kullanımdan oralkullanıma geçiş oranlarının artırılmasına ve nihai olarak bakım kalitesinin iyileştirilmesine fayda sağladıkları sonucuna varılmıştır. Ülkemizde klinik eczacılık uzmanlık eğitiminin başlamış olması, meslek içi eğitim programlarının artırılması ve klinik eczacılık lisansüstü programlarının yaygınlaştırılması, eczacının buçalışmada adı geçen görevleri yerine getirebilmesi için önemli fırsatlardır.
Open Access
Determination of Potential Drug-Drug Interactions Using Various Software Programs in a Community Pharmacy Setting
(TURKISH PHARMACISTS ASSOC, 2019-03-01) OKUYAN, BETÜL; Sancar, Mesut; Kasik, Aksa; Okuyan, Betul; Batuhan, Sevda; Izzettin, Fikret Vehbi
Objectives: The aim of the present study was to compare various software programs in detecting potential drug-drug interactions in a community pharmacy setting. Materials and Methods: Details of prescriptions were collected from 50 community pharmacies located in Istanbul in March and April 2015 (two days per week). From each pharmacy, the first 20 prescriptions that included more than one drug were collected to evaluate potential drug-drug interactions. The following software programs were utilized to detect potential drug-drug interactions: micromedexsolutions.com , medscape.com , and drugs.com . The number of potential interactions detected by the software programs was determined. Results: At least one potential drug-drug interaction was detected in 39.2% of the 1000 prescriptions by one of the software programs. According to the rates of total drug-drug interactions gathered from various software programs, these programs gave the following results: medscape.com 33.3%, drugs.com 31.3%, and micromedexsolutions.com 21.2%. Conclusion: After comparing different software programs, the potential drug-drug interactions found by the programs proved to be different. Therefore, we recommend that pharmacists confirm with a different program before making a decision when they detect clinically significant potential drug-drug interactions.
Open Access
Clinical pharmacist-led medication reconciliation service in patients with infectious disease during COVID-19 pandemic
(2021-10-29) ERTÜRK ŞENGEL, BUKET; SANCAR, MESUT; OKUYAN, BETÜL; KORTEN, VOLKAN; ENVER C., ERTÜRK ŞENGEL B., SANCAR M., KORTEN V., OKUYAN B.
Open Access
Determination of CYP2C19 Polymorphism, Side Effects, and Medication Adherence in Patients Who have Utilized Selective Serotonin Reuptake Inhibitors
(KURE ILETISIM GRUBU A S, 2016-06) OKUYAN, BETÜL; Deniz, Semanur; Sancar, Mesut; Okuyan, Betul; Ata, Pinar; Ozakpinar, Ozlem Bingol; Talas, Anil; Gunes, Tufan; Caliskan, Mecit; Izzettin, Fikret Vehbi
Objective: The aim of this study is to determine relationship of cytochrome P-450 2C19 (CYP2C19) enzymes polymorphism, side effects, and medication adherence in patients who have been diagnosed with major depression and have utilized selective serotonin reuptake inhibitors. Methods: Fifty-three major depression patients (mean of age: 33.25 +/- 11.29 years old; male/female: 7/46) were included in this study. Polymorphisms were determined from genomic DNA by using the 'Real-Time Polymerase Chain Reaction' method. Side effects and medication adherence levels were assessed by using the 'Toronto Side Effects Scale' and the four items medication adherence scale (Morisky, Green and Levine), respectively. Results: The most common side effects that patients reported were drowsiness/daytime somnolence (54.7%), malaise or fatigue (43.4%), sweating (43.4%), nausea (41.5%) and dry mouth (41.5%). Only nine (17%) patients were found to be highly adherent to their medication. When evaluating the CYP2C19 polymorphisms of patients, 37.7%, 24.5% and 20.8% of the patients were classified as intermediate, extensive and ultra-rapid metabolizers, respectively. Allele frequencies of CYP2C19*17 and CYP2C19* 2 was calculated as 24.5% and 27.4%, respectively. Although there were some differences in side effect scores and medication adherences among the polymorphism groups, these relationships were not found to be statistically significant. Conclusion: This study shows that patients who utilized antidepressants frequently experienced side effects and had low medication adherence. Another interesting finding is the high rate of ultrarapid metabolizers of CYP2C19.
Open Access
Evaluation of knowledge and attitude of pharmacist and pharmacy technicians on emergency contraception method in Istanbul, Turkey: A simulated patient study
(2019-05-15) OKUYAN, BETÜL; Sancar, Mesut; Okuyan, Betül; Uzun, Gül Duygu
Open Access
Medication reconciliation service in hospitalized patients with infectious diseases during coronavirus disease-2019 pandemic: An observational study
(2023-08-01) ENVER, CÜNEYD; ERTÜRK ŞENGEL, BUKET; SANCAR, MESUT; KORTEN, VOLKAN; OKUYAN, BETÜL; ENVER C., ERTÜRK ŞENGEL B., SANCAR M., KORTEN V., OKUYAN B.
Objectives: To determine the prevalence and type of medication discrepancies and factors associated with unintentional discrepancies and identify the rate of hospital readmission and emergency service visit within 30 days after discharge among hospitalized patients with infectious diseases and receiving clinical pharmacist-led medication reconciliation during the coronavirus disease-2019 (COVID-19) pandemic. Materials and Methods: This observational study was conducted in the internal medicine and infectious diseases wards of a tertiary university hospital between July 2020 and February 2021 among hospitalized adult patients with infectious diseases. Medication reconciliation service (including patient counseling) was provided in person or by telephone. The number and type of medication discrepancies detected during the medication reconciliation services, the acceptance rate of pharmacists’ recommendation, and factors associated with having at least one unintentional medication discrepancy at admission were evaluated. At follow-up, hospital readmission and emergency service visit within 30 days after discharge were assessed by telephone. Results: Among 146 patients, 84 (57.5%) had at least one unintentional discrepancy at admission. Only three unintentional discrepancies were determined in three patients at hospital discharge. All the pharmacists’ recommendations for medication discrepancies were accepted by the physicians. Having COVID-19 [odds ratio (OR): 2.25, 95% confidence interval (CI): 1.15-4.40; p<0.05], being at a high risk for medication error (OR: 2.01, 95% CI: 1.03-3.92; p<0.05), and higher number of medications used at home (OR: 1.41, 95% CI: 1.23-1.61; p<0.001) were associated with having at least one unintentional discrepancy at admission. The rates of 30 day hospital readmission and admission to the emergency medical service were 12.3% and 15.8%, respectively. Conclusion: Medication reconciliation service provided by in-person or by telephone was useful for detecting and solving unintentional medication discrepancies during the COVID-19 pandemic.
Open Access
Assessment of the pharmacy students' e-health literacy and mobile health application utilization
(MARMARA UNIV, 2020-01-13) OKUYAN, BETÜL; Ustun, Gozde; Soylemez, Sumeyra Lubeyne; Ucar, Nazlican; Sancar, Mesut; Okuyan, Betul
The aim of this study is to evaluate pharmacy students' behaviours towards mobile health applications and e-health literacy. This electronic descriptive and cross-sectional study was conducted in pharmacy students in Istanbul, Turkey for two months. A questionnaire was designed based on the previous studies to evaluate knowledge and behaviours, point of view and perception about mobile health apps in pharmacy students. Turkish version of the eHealth Literacy Scale (eHEALS) was applied to the pharmacy students. The response rate was 88.10% (n=229). Among 260 pharmacy students, mobile health apps users and male pharmacy students had statistically higher eHEALS score when compared with non-users and female pharmacy students (p<0.05). Fifth-grade pharmacy students had statistically higher scores when compared with the third-grade pharmacy students (p<0.001). It was found that 83.08% (n=216) pharmacy students said that mobile health apps improve patient's quality of life whereas 30.00% (n=78) thought that pharmacists have not sufficient knowledge of the using mobile health apps. As a conclusion, it was seen that pharmacy students knowledge and behaviours towards mobile health application will he increased with improving their e-health literacy levels.
Open Access
Evaluation of satisfaction and internet self-efficacy of inquirers using an internet-based drug information centre
(ELSEVIER SCIENCE BV, 2019-02) OKUYAN, BETÜL; Izzettin, Fikret, V; Yilmaz, Zekiye K.; Okuyan, Betul; Sancar, Mesut
Objectives: This study aimed to evaluate the satisfaction level of inquirers of an internet-based drug information centre along with the internet usage abilities and habits of individuals who had previously utilised services from an internet-based drug information centre in Turkey. Methods: The first 100 individuals who received medication consultancy from the webpage entitled www.ilacpedia.com and consented to participate in the study were included in this study. This website is an internet-based drug information centre. Participants' data were collected using a participant data form and the Internet Self-efficacy Scale. Results: The mean age of participants was 37.92 +/- 12.32 years (71 female). It was found that 89% of the individuals who received pharmaceutical consultation from the internet-based drug information service believed that the information that they received was enough to solve their problem. The internet self-efficacy scale scores indicated the highest score on the decomposition subscale (20.94 +/- 6.18) and the lowest on the communication subscale (9.77 +/- 3.57). Conclusions: The present study revealed that the internet-based drug information service provided by clinical pharmacists contributed positively to users' satisfaction, thus indicating the importance of the involvement of clinical pharmacists in this process.
Open Access
Determination of side effects and medication adherence in major depression patients utilized antidepressants
(MARMARA UNIV, FAC PHARMACY, 2016-09-20) OKUYAN, BETÜL; Sancar, Mesut; Duzgun, Emine; Okuyan, Betul; Deniz, Semanur; Caliskan, Mecit; Coskun, Kadir; Izzettin, Fikret Vehbi
The aim of the study is to determine side effects, and medication adherence in patients who were diagnosed with major depression utilized antidepressants. This study was conducted in outpatient psychiatry clinic between February 2013 and May 2013. 'Toronto Side Effects Scale' and 4-item Morisky-Green-Levine Medication Adherence Scale were evaluated. Fifty-six major depression patients (mean of age: 40.82 +/- 14.28 years old; male/female: 13/43) were included in this study. Patients were treated with escitalopram (46.4%), sertraline (26.8%), venlafaxine (10.7%), citalopram (8.9%) and paroxetine (7.1%). The most common side effects that patients reported were drowsiness/daytime somnolence (57.1%), dry mouth (46.4%) and increased sleep (46.4%), increased appetite (37.5%) and malaise or fatigue (30.4%). The most severity side effects that patients experienced were drowsiness/daytime somnolence (25%), increased sleep (19.6%) and decreased libido (14.3%). Only fifteen (26.8%) patients were found high adherent to their medication. It was concluded that although the frequency and severity of side effects have been found high, the percentage of patients' medication adherence has been obtained low. Patient education and monitoring regarding side effects and medication adherence providing by pharmacists would be contributed to prevent possible drug induced problems in these patients besides the routine services they are taken from outpatient clinic.
Open Access
The impact of clinical pharmacist-led hypertension screening at the community pharmacy in Türkiye
(2022-01-01) OKUYAN, BETÜL; SANCAR, MESUT; Demircioglu Akyilmaz C. E. , OKUYAN B., SANCAR M.
© 2022 Marmara University Press.The aim of this study was to evaluate the impact of clinical pharmacist-led hypertension screening program (including referring high-risk individuals who are not aware of being hypertensive or prehypertensive to the physician) at a community pharmacy in Türkiye. This prospective observational pilot study was conducted in a community pharmacy located in Mersin-Türkiye between October 2017 and April 2018. Blood pressure measurements were performed by the clinical pharmacist at baseline and follow-up. The rate of participants who had high blood pressure measurements (≥140 mmHg for systolic and/or ≥90 mmHg for diastolic) was determined at the baseline by clinical pharmacist. According to the guidelines, participants with high blood pressure were referred directly to the physician by the clinical pharmacist. In the follow-up, the number of patients diagnosed with prehypertension or hypertension and the changes in their measurement of blood pressure were identified between baseline and follow-up. According to findings of clinical pharmacist-led blood pressure measurement, 23 (37.1%) out of 62 participants with high blood pressure were referred to the physician by the clinical pharmacist. In the follow-up, it was determined that 12 patients (52.2%) out of 23 participants were diagnosed with hypertension by a physician and eight patients (34.8%) out of 23 participants had prehypertensive. According to the findings of this pilot study, it was determined a positive impact of the clinical pharmacist-led hypertension screening program for high-risk individuals for hypertension.