Person: OKUYAN, BETÜL
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
OKUYAN
First Name
BETÜL
Name
16 results
Search Results
Now showing 1 - 10 of 16
Publication Metadata only Evaluation of potentially inappropriate medication utilization in elderly patients with cancer at outpatient oncology unit(SAGE PUBLICATIONS LTD, 2019) OKUYAN, BETÜL; Paksoy, Ceylan; Ozkan, Oznur; Ustaalioglu, Bala B. O.; Sancar, Mesut; Demirtunc, Refik; Izzettin, Fikret V.; Okuyan, BetulBackground The aim of the study was to evaluate potentially inappropriate medication use in elderly patients with cancer. Method This study was conducted at outpatient oncology clinic from December 2014 to March 2015 among elderly cancer patients. Screening Tool of Older Person's Prescriptions/Screening Tool to Alert doctors to Right Treatment criteria were used to identify potentially inappropriate medication in elderly patients. Results Among 114 cancer patients 55.26% of them were male and the mean age of them was 71.78 +/- 5.50 (years). The most common concurrent diseases were hypertension in 45 (39.47%) and diabetes in 26 (22.81%) patients. Polypharmacy (>= 5 medications) was seen in 94.73% of them. Eighteen patients (15.79%) utilized medications inappropriately according to Screening Tool of Older Person's Prescriptions criteria. Medication omissions were identified in 112 patients (98.25%) with Screening Tool to Alert doctors to Right Treatment criteria. Conclusions Clinical pharmacists could improve the current prescribing practices in elderly patients with cancer by assessing potentially inappropriate medications.Publication Metadata only The effect of pharmacist-led education on inhaler use skills in hospitalised patients with chronic obstructive pulmonary disease(BMJ PUBLISHING GROUP, 2015) OKUYAN, BETÜL; Sancar, Mesut; Sirinoglu, Yasemin; Okuyan, Betul; Karagoz, Turan; Izzettin, Fikret VehbiObjective To assess patient inhalation skills and the effect of pharmacist-led education on these skills in chronic obstructive pulmonary disease (COPD) patients using inhalers in a hospital setting. Methods Pre- and 1month post-intervention were evaluated by scoring essential steps during inhaler use for each inhaler device. Results 41 patients participated in the study (mean age 64.3611.78 years, range 29-83 years). The female-male ratio was 7:34. Patients' inhaler administration skills were found to be improved by pharmacist-led education (p<0.05). Conclusions Evaluation of accurate inhaler device usage in patients with COPD should be performed periodically, and training regarding the inhaler device should be reconsidered according to the needs of patients.Publication Metadata only Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats(ELSEVIER, 2017) OKUYAN, BETÜL; Bami, Erliasa; Ozakpinar, Ozlem Bingol; Ozdemir-Kumral, Zarife Nigar; Koroglu, Kutay; Ercan, Feriha; Cirakli, Zeynep; Sekerler, Turgut; Izzettin, Fikret Vehbi; Sancar, Mesut; Okuyan, BetulThis study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.Publication Metadata only Adverse drug reactions due to drug- drug interactions with proton pump inhibitors: assessment of systematic reviews with AMSTAR method(TAYLOR & FRANCIS LTD, 2016) OKUYAN, BETÜL; Yucel, Emre; Sancar, Mesut; Yucel, Aylin; Okuyan, BetulIntroduction: Many systematic reviews resulted in claims on drug-drug interactions (DDIs) with proton pump inhibitors (PPIs). Such a large number begs for consensus on the clinical significance of findings.Areas covered: We critically evaluated the safety of PPI use with respect to DDIs with a meta-review of systematic reviews published between 1978 and 2015. We assessed the evidence by their reliability, repeatability, transparency, and objectivity according to the Assessment of Multiple Systematic Reviews (AMSTAR) criteria.Expert opinion: Clinicians must assess risks for each PPI for certain comorbid conditions. DDIs don't substantiate class effect for PPIs; each PPI could induce unique DDIs. Concomitant use of PPIs with thienopyridines (e.g. clopidogrel) could be justified in patients without strong affinity to cytochrome CYP2C19 and with high risk of bleeding (e.g. patients with prior upper gastrointestinal bleeding, Helicobacter pylori infection, advanced age, steroid treatment, and nonsteroidal anti-inflammatory drug use). DDIs could occur in an AIDS subpopulation treated with highly active antiretroviral therapy (HAART). DDIs exist for cancer patients undergoing targeted therapy. Hypomagnesemia could increase in the setting of advanced age and polypharmacy. Omeprazole poses high risks owing to its pharmacokinetic DDI profile. Future systematic reviews should incorporate these additional risks for better clinical guidancePublication Metadata only The impact of pharmacist-led smoking cessation program at community pharmacy(2012-01-01) SANCAR, MESUT; OKUYAN, BETÜL; Atalay L., SANCAR M., OKUYAN B., Izzettin F. V.Amaç: Çalışmada, bir serbest eczanede klinik eczacı tarafından yürütülen ‘nikotin replasman tedavisiyle (nikotin sakızı ve nikotin tabletini içeren) sigara bırakma programının bir yıllık sonuçlarının değerlendirilmesi amaçlanmıştır. Yöntem: Çalışma Haziran 2009 - Haziran 2010 tarihleri arasında gerçekleştirilmiştir. İlk görüşmede katılımcıların demografik ve klinik verileri toplanmış ve her bir katılımcıya ‘Fagerstrom Nikotin Bağımlılık Testi’ uygulanmıştır. Daha sonra klinik eczacı tarafından katılımcılar sigaranın zararları hakkında bilgilendirilmiş ve her bir katılımcının bağımlılık derecesine göre uygun OTC (tezgah üstü ilaç- reçetesiz ilaç) nikotin replasman ürünü tavsiye edilmiştir. Katılımcılar klinik eczacı tarafından on iki ay boyunca yüz yüze veya telefonla yapılan düzenli görüşmelerle takip edilmiştir. Bulgular: Çalışmaya katılan 33 katılımcının yaş ortalaması 41.57±11.90 (aralık: 24-66 yıl) olarak hesaplanmıştır. Fagerstrom Nikotin Bağımlılık Testi sonuçlarına göre katılımcıların onbeşinde düşük nikotin bağımlılığı, dokuzunda orta bağımlılık ve kalan dokuz katılımcıda ise yüksek nikotin bağımlılığı saptanmıştır. Hastaların ikisi bir yıllık takipte kaybedilmiş, çalışma 31 hasta ile tamamlanmıştır. Çalışma sonunda, klinik eczacı danışmanlığında serbest eczanede yürütülen sigara bırakma programıyla bir yıl boyunca takip edilen otuz bir katılımcının yirmisinin (%64.5) sigara kullanmayı bıraktığı görülmüştür. Sonuç: Bu bilgiler ışığında, eğitimli ve kolay ulaşılabilir sağlık mensupları olan eczacıların sigara bırakma programlarında aktif rol almaları gerekmekte olduğu sonucuna ulaşılmıştır. Anahtar sözcükler: Sigara bırakma, klinik eczacılık, nikotin replasman tedavisiPublication Metadata only Validation of the Turkish version of medication regimen complexity index among elderly patients(WILEY, 2016) OKUYAN, BETÜL; Okuyan, Betul; Babi, Bedis; Sancar, Mesut; Ay, Pinar; Yucel, Emre; Yucel, Aylin; Izzettin, Fikret VehbiObjectiveThe aim of this study was to validate the Turkish version of the Medication Regimen Complexity Index' (MRCI). MethodsThis validation study has been conducted in prescriptions of the first 100 elderly patients who had visited the pharmacy for their prescription refill to evaluate convergent and divergent validity of the Turkish version. The reliability of the Turkish version was assessed with inter-rater and test-retest analysis after its translation and cultural adaptation. ResultsThe mean age of the 100 patients (53 women) was 74.9years (SD=7.58, 65-95). The scale showed high inter-rater reliability and test-retest reliability for the total and subscale scores (p<0.05). A strong and positive correlation between the number of medications in a prescription and the total Medication Regimen Complexity Index scores (r=0.930, p<0.001) was determined. There were no statistically significant differences between age, gender and MRCI scores (p>0.05). ConclusionThese results show that the Turkish version of MRCI is a reliable and valid tool in elderly patients.Publication Metadata only Determination of geriatric patients' drug profile and identify their pharmaceutical care requirements by determining potential risk factors(SPRINGER, 2011) OKUYAN, BETÜL; Sancar, M.; Mutlu, B. Yalcin; Okuyan, B.; Izzettin, F. VehbiPurpose: The aim of this study is to evaluate the geriatric drug usage, assess the appropriateness of their drug treatment and identify their pharmaceutical care requirements. Patients and methods: The demographic, clinical and drug data of the patients was obtained. Patients' knowledge about their drugs was also assessed. The patients at risk of drug induced problems were defined and a risk map was determined. Patients, who were 65-years-old and over and live in a nursing home in the Anatolian part of Istanbul, were included in our study. Results: Polypharmacy was identified in 44% of those included in the study (total of 146 patients who take drug therapy). Eighty of the patients (54.8%) did not know reason they were taking drugs. Eighty-eight of the patients (60.3%) were not aware how or when they should take drugs. Although, 24 patients (16.4%) were using their drugs by self-administration, the drugs of 122 patients (83.6%) were administered by their nurse; 24.65% of patients were in a high-risk category. The mean of number of drug used by patients was 5.89 +/- 3.61. Discussion and conclusions: According to our results, patients have lack of knowledge about drug usage and they have rarely been informed about rationale drug usage. First, it is necessary to determine geriatric patients' pharmaceutical care needs in order to prevent and solve their drug-related problems. Pharmacists will contribute to the development and spread of patient oriented pharmacy services by working in specialist geriatric teams with physicians, nurses and other health professionals. (c) 2011 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.Publication Metadata only Investigation of Physicians' Perspectives of Drug Promotional Activities(AVES PRESS LTD, 2016) OKUYAN, BETÜL; Akici, Ahmet; Kilboz, Mehmet Murat; Mollahaliloglu, Salih; Ozgulcu, Senay; Alkan, AliObjective: Pharmaceutical company promotional activities (PCPAs) are listed among the factors that influence the prescribing behavior of physicians. This study aimed to determine the opinions of family physicians (FPs) and specialist physicians (SP) on the impact of these activities. Methods: A survey comprising 1062 FPs working in primary health centers and 562 SPs working in public hospitals at different cities in Turkey was conducted. The questions thoroughly evaluated physicians' approaches toward PCPAs, particularly drug promotional activities. Answers were evaluated with respect to the demographic and occupational characteristics of physicians. Results: Based on the statements of participants, 82.8% of FPs and 88.6% of SPs declared that physicians always or sometimes are influenced by PCPAs. Percentage of SPs who declared themselves as always or sometimes influenced by PCPAs was significantly higher than that of FPs (p=0.006). Overall, 56.3% of FPs and 43.3% of SPs were visited >5 times during the last 5 working days by pharmaceutical sales representatives. When considering features of drugs prescribed after PCPAs, both FPs and SPs declared that these drugs were cheaper (52.8% and 47.8%, respectively) and safer (52.7% and 49.3%, respectively) than their alternatives. Conclusion: Physicians' statements showed that they were often visited by pharmaceutical sales representatives and highly influenced by PCPAs. Differences with respect to the experiences and approaches of FPs and SPs regarding this issue are critical factors warranting careful consideration of a rational PCPA implementation.Publication Metadata only Turkish Validation of Patient Satisfaction Towards Patient Oriented Pharmacy Services Questionnaire in Patients with Chronic Disease(AVES PRESS LTD, 2016) OKUYAN, BETÜL; Okuyan, Betul; Hucum, Hakan; Sancar, Mesut; Ay, Pinar; Izzettin, Fikret VehbiObjective: The aim of the study was to validate the Turkish version of the patient satisfaction questionnaire that evaluated satisfaction of patients with chronic diseases regarding pharmacy services. Methods: The present study was conducted between September 2015 and November 2015 among patients who had chronic diseases at least for 6 months and applied to community pharmacies. After appropriate language translation, pre-test, test-retest validity, and factor analysis were conducted. Results: The mean age of 154 patients (91 male, 63 female) was 58.6 +/- 13.8 years. The mean score of the Patient-Oriented Pharmacy Services Questionnaire (PSPSQ) 2.0 was 3.29 +/- 0.47, and the Cronbach's alpha coefficient was 0.944. A strong correlation was determined between the test-retest validity of the total and subscale scores (p<0.001). Three domains (quality of care, patient-pharmacist relationship, and overall satisfaction) were obtained in factor analysis of PSPSQ 2.0, as in the original study. Conclusion: In the present study, the Turkish form of PSPSQ 2.0 was determined to be a reliable and valid scale to assess patients' satisfaction regarding patient-oriented pharmacy services.Publication Metadata only Effect of antituberculous drugs on human polymorphonuclear leukocyte functions in vitro(ELSEVIER SCIENCE BV, 2005) OKUYAN, BETÜL; Okuyan, B; Izzettin, FV; Sancar, M; Ertas, O; Cevikbas, A; Gurer, USThe aim of the study was to investigate antituberculous drugs effects on polymorphonuclear leukocyte (PMN) functions (phagocytic activity and intracellular killing activity) in vitro. PMNs obtained from healthy volunteers were incubated with antituberculous drugs (isoniazid [INH], rifampin [RIF], pyrazinamide [PZA], ethambutol [EMB], streptomycin [S], amikacin [A], ofloxacin [OFLX], prothionamide [PTH] and cycloserine [CyC]) and different combinations at therapeutic serum concentrations. Phagocytic activity of PMNs was significantly increased when compared with controls by PTH (p<0.001), A (p<0.001), OFLX (p<0.001), INH+RIF+S combination (p<0.01), A+OFLX combination (p<0.05), A+OFLX+CyC combination (p<0.01) and A+OFLX+CyC+PTH+EMB combination (p<0.01). Intracellular killing activity of PMNs was significantly increased by OFLX when compared with the control (p<0.05). No significant difference was observed in functions of PMN for other drugs when compared with control (p>0.05). Functions of PMN were significantly increased by OFLX when compared with A+OFLX combination (p<0.05). Phagocytic activity of PMNs was significantly increased by A+OFLX+CyC combination and A+OFLX+CyC+PTH+EMB combination when compared with A+OFLX+CyC+PTH combination and A+OFLX+CyC+PTH+PZA combination (p<0.05). No significant difference was found in functions of PMN between the other groups (p>0.05). In conclusion, some antituberculous drugs alone or in combination enhanced PMN functions, although in combination no additive or synergistic effects were detected. Moreover, none of the antituberculous drugs alone or in combination significantly decreased PMN functions. The drugs having adverse effects on immune functions would better be replaced with equally effective drugs or drug combinations having positive effects on PMN functions. (C) 2005 Published by Elsevier B.V.