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OKUYAN, BETÜL

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Eczacılık Fakültesi

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OKUYAN

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BETÜL

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Now showing 1 - 9 of 9

Open Access
Medication reconciliation service in hospitalized patients with infectious diseases during coronavirus disease-2019 pandemic: An observational study
(2023-08-01) ENVER, CÜNEYD; ERTÜRK ŞENGEL, BUKET; SANCAR, MESUT; KORTEN, VOLKAN; OKUYAN, BETÜL; ENVER C., ERTÜRK ŞENGEL B., SANCAR M., KORTEN V., OKUYAN B.
Objectives: To determine the prevalence and type of medication discrepancies and factors associated with unintentional discrepancies and identify the rate of hospital readmission and emergency service visit within 30 days after discharge among hospitalized patients with infectious diseases and receiving clinical pharmacist-led medication reconciliation during the coronavirus disease-2019 (COVID-19) pandemic. Materials and Methods: This observational study was conducted in the internal medicine and infectious diseases wards of a tertiary university hospital between July 2020 and February 2021 among hospitalized adult patients with infectious diseases. Medication reconciliation service (including patient counseling) was provided in person or by telephone. The number and type of medication discrepancies detected during the medication reconciliation services, the acceptance rate of pharmacists’ recommendation, and factors associated with having at least one unintentional medication discrepancy at admission were evaluated. At follow-up, hospital readmission and emergency service visit within 30 days after discharge were assessed by telephone. Results: Among 146 patients, 84 (57.5%) had at least one unintentional discrepancy at admission. Only three unintentional discrepancies were determined in three patients at hospital discharge. All the pharmacists’ recommendations for medication discrepancies were accepted by the physicians. Having COVID-19 [odds ratio (OR): 2.25, 95% confidence interval (CI): 1.15-4.40; p<0.05], being at a high risk for medication error (OR: 2.01, 95% CI: 1.03-3.92; p<0.05), and higher number of medications used at home (OR: 1.41, 95% CI: 1.23-1.61; p<0.001) were associated with having at least one unintentional discrepancy at admission. The rates of 30 day hospital readmission and admission to the emergency medical service were 12.3% and 15.8%, respectively. Conclusion: Medication reconciliation service provided by in-person or by telephone was useful for detecting and solving unintentional medication discrepancies during the COVID-19 pandemic.
Open Access
The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds
(2022-01-01) OKUYAN, BETÜL; ŞEN, ALİ; ŞENER, GÖKSEL; ERCAN, FERİHA; Erta B., OKUYAN B., ŞEN A., ERCAN F., Onel H., GÖGER F., Sener G.
The overall aim of the present research is to evaluate for the first time the curative effect of Cotinus coggygria leaves on burn injury in an experimental burn model along with its anti-inflammatory and antioxidant activity potential. Also, phenolic compounds of C. coggygria were characterised by LC-MS/MS. Wistar albino rats weighing 200-250 g were exposed to 90 degrees C bath for 10 s to induce burn injury, involving 30% of the total body surface area. In the treatment groups, 5% C. coggygria ethanol extract was applied topically as a cream immediately after the burn. Blood and skin tissue samples were taken after decapitation at the 4th and 48th hours following the burn procedure. Interleukin 1-beta (IL-1 beta) and tumour necrosis factor (TNF-alpha) were determined in serum samples, and hydroxyproline, prostoglandin E2 (PGE2), and myeloperoxidase (MPO) activity and 8-hydroxy-2\"-deoxy-guanosine (8-OHdG) levels were determined in skin tissue samples. Increased levels of serum cytokines were decreased with C. coggygria treatment in both periods. MPO activity, prostaglandine (PGE2), and 8-OhdG levels increased, while hydroxyproline levels decreased due to burn damage. On the other hand, these parameters were returned to its normal levels with C. coggygria treatment. In addition, the tissue histology of animals treated with C. coggygria showed a complete epithelialization with increased collagenation. As a result, C. coggygria may be an alternative treatment approach for burns-induced skin damage and wounds.
Open Access
The impact of clinical pharmacist-led hypertension screening at the community pharmacy in Türkiye
(2022-01-01) OKUYAN, BETÜL; SANCAR, MESUT; Demircioglu Akyilmaz C. E. , OKUYAN B., SANCAR M.
© 2022 Marmara University Press.The aim of this study was to evaluate the impact of clinical pharmacist-led hypertension screening program (including referring high-risk individuals who are not aware of being hypertensive or prehypertensive to the physician) at a community pharmacy in Türkiye. This prospective observational pilot study was conducted in a community pharmacy located in Mersin-Türkiye between October 2017 and April 2018. Blood pressure measurements were performed by the clinical pharmacist at baseline and follow-up. The rate of participants who had high blood pressure measurements (≥140 mmHg for systolic and/or ≥90 mmHg for diastolic) was determined at the baseline by clinical pharmacist. According to the guidelines, participants with high blood pressure were referred directly to the physician by the clinical pharmacist. In the follow-up, the number of patients diagnosed with prehypertension or hypertension and the changes in their measurement of blood pressure were identified between baseline and follow-up. According to findings of clinical pharmacist-led blood pressure measurement, 23 (37.1%) out of 62 participants with high blood pressure were referred to the physician by the clinical pharmacist. In the follow-up, it was determined that 12 patients (52.2%) out of 23 participants were diagnosed with hypertension by a physician and eight patients (34.8%) out of 23 participants had prehypertensive. According to the findings of this pilot study, it was determined a positive impact of the clinical pharmacist-led hypertension screening program for high-risk individuals for hypertension.
Open Access
Reliability of high-alert medications questionnaire in Turkish healthcare professionals
(2022-01-01) ALTIPARMAK, ÖZNUR; SANCAR, MESUT; OKUYAN, BETÜL; Ozturk F., Altiparmak O., Torun B., Bektay M. Y., SANCAR M., OKUYAN B.
Objective: This study aimed to evaluate the reliability of the HighAlert Medications (HAM) Questionnaire in Turkish healthcare professionals. Methods: This methodological study was conducted between December 2017 and January 2018 in a private university hospital. The healthcare professionals, including nurses, health service technicians, and pharmacists, who are older than 18 years old were eligible for this study. After following the appropriate translation and cultural adaptation process, the internal consistency of the HAM Questionnaire using the Kuder-Richardson 20 coefficient and test-retest reliability was evaluated. Results: Among 146 healthcare professionals, the mean age was 25.40±5.16 years, wherein 76% were females. Most participants were nurses (69.9%) and other healthcare professionals were health service technicians (28.1%) and pharmacists (2.0%). The mean total score of the HAM Questionnaire was 70.00±19.50. The KuderRichardson 20 was 0.815. A statistically significant correlation was found between the scores of the HAM Questionnaire at baseline and after 15 days, which confirmed the test-retest reliability (r=0.527; p<0.01). A statistically significant correlation was found between the HAM Questionnaire score and advanced age (r=0.310; p<0.001) and higher professional year (r=0.445; p<0.001). Conclusion: The Turkish version of the HAM Questionnaire could be used to assess healthcare professionals’ knowledge about highalert medications.
Open Access
Medication Review in Turkish Older Adults at Community Pharmacy: A Pilot Study by Using Medication Appropriateness Index
(2022-09-01) ALTIPARMAK, ÖZNUR; SANCAR, MESUT; OKUYAN, BETÜL; Dal S., Ucar N., ALTIPARMAK Ö., SANCAR M., OKUYAN B.
Objective: The study aimed to evaluate medication review in older adults (≥65 years) at a community pharmacy by identifying the prevalence of potentiality inappropriate medication and calculating medication appropriateness index. Methods: This descriptive study was carried out in a community pharmacy for six months. The older adults (≥65 years) using one or more medications were included. During clinical pharmacist-led medication review; the medication appropriateness index was calculated for each medication of older adults. Potentially inappropriate medications were evaluated according to the 2019 American Geriatrics Society Beers Criteria®. Result: Among a hundred older adults, 46.0% were female. The median age of the patients was 75.5 (IQR, 68.0-78.8). The median number of medications was 9.0 (7.0-10.0). Polypharmacy has been detected in 97.0% of the patients. At least one potentially inappropriate medication was detected in 63.0% of them. The median score of medication appropriateness index score was 53.0 (IQR: 38.6-67.9). Conclusion: To best our knowledge, this is the first study of clinical pharmacist-led medication review by calculating the medication appropriateness index carried out at a community pharmacy in Turkey. There was a high rate of potentially inappropriate medication with a higher score of medication appropriateness in older adults. This study highlights the importance of medication review led by the clinical pharmacist at community pharmacy to optimize medication usage in older adults. Keywords: Older adults, clinical pharmacist, medication appropriateness index, potentially inappropriate medication
Open Access
Scope, content and quality of clinical pharmacy practice guidelines: a systematic review
(2023-01-01) OKUYAN, BETÜL; Paudyal V., OKUYAN B., Henman M. C., Stewart D., Fialová D., Hazen A., Lutters M., Oleárová A., Weidmann A. E., Wirth F., et al.
Background: Guidelines for pharmacy practitioners regarding various clinical pharmacy activities have been published in a number of countries. There is a need to review the guidelines and identify the scope of activities covered as a prelude to developing internationally acceptable common guidelines. Aim: To review the scope of clinical pharmacy guidelines and assess the extent to which these guidelines conform to quality standards as per the AGREE II instrument. Method: Medline, Embase, Guideline Central, International Pharmaceutical Abstracts, Google Scholar and Google (for grey literature) were searched for the period 2010 to January 2023. Guidelines which focused on any health care setting and any clinical pharmacy activity were included. Data were extracted and quality assessed independently by two reviewers using the English version of the AGREE II instrument. Results: Thirty-eight guidelines were included, mostly originating from Australia (n = 10), Ireland (n = 8), UK (n = 7) and USA (n = 5). Areas covered included medication reconciliation, medicines optimisation, medication management and transition of care. As per the AGREE II assessment, the highest score was obtained for the scope and purpose domain and the lowest score for rigour of development, mainly due to non-consideration of literature/evidence to inform guideline development. Conclusion: Clinical pharmacy guidelines development processes need to focus on all quality domains and should take a systematic approach to guideline development. Guidelines need to further emphasise person-centred care and clinical communication. There is a scope to harmonise the guidelines internationally considering the diverse practices, standards and legislations across different geographies.
Open Access
Alendronat tedavisinin senil osteoporozlu hastalarda idrar kalsiyum/kreatinin oranı üze- rine etkisinin değerlendirilmesi
(2011-01-01) OKUYAN, BETÜL; SANCAR, MESUT; Yorukoglu E., OKUYAN B., SANCAR M., Izzettin F. V.
Amaç: Bu çalışmada, alendronat kullanan senil osteoporozlu kadınlarda alendronat tedavisinin idrar kalsiyum/kreatinin oranları üzerine etkisinin değerlendirilmesi amaçlanmıştır. Yöntem: Bu amaçla, tedavi öncesi ve 3 aylık tedavi sonrasında hastaların idrar kalsiyum/kreatinin oranları ölçülmüş ve ayrıca serum kalsiyum, fosfor, alkalen fosfataz (ALP), paratiroid hormon (PTH) değerlerinin sonuçları değerlendirilmiştir. Bulgular: 3 aylık tedaviden sonra idrar kalsiyum/kreatinin oranında ve serum ALP, kalsiyum ve fosfor düzeylerinde istatistiksel olarak anlamlı bir düşüş ve serum PTH düzeyinde de bu değişikliklere cevap olarak anlamlı yükselme görülmüştür (p<0.05). Sonuç: Tedavi başlangıcında osteoporoz hastalarının tedavi etkinliğinin ve uyuncunun değerlendirilmesi için idrar kalsiyum/kreatinin oranının izlem parametresi olarak kullanılabileceği sonucuna varılmıştır.
Open Access
How to write a successful grant application: guidance provided by the European Society of Clinical Pharmacy
(2023-03-01) OKUYAN, BETÜL; Weidmann A. E., Cadogan C. A., Fialova D., Hazen A., Henman M., Lutters M., OKUYAN B., Paudyal V., Wirth F.
Considering a rejection rate of 80-90%, the preparation of a research grant is often considered a daunting task since it is resource intensive and there is no guarantee of success, even for seasoned researchers. This commentary provides a summary of the key points a researcher needs to consider when writing a research grant proposal, outlining: (1) how to conceptualise the research idea; (2) how to find the right funding call; (3) the importance of planning; (4) how to write; (5) what to write, and (6) key questions for reflection during preparation. It attempts to explain the difficulties associated with finding calls in clinical pharmacy and advanced pharmacy practice, and how to overcome them. The commentary aims to assist all pharmacy practice and health services research colleagues new to the grant application process, as well as experienced researchers striving to improve their grant review scores. The guidance in this paper is part of ESCP\"s commitment to stimulate \"innovative and high-quality research in all areas of clinical pharmacy\".
Open Access
Assessment of pharmacy students’ knowledge of handling high alert medications
(2023-01-01) OKUYAN, BETÜL; SELÇUK A., OKUYAN B.
Objective: High alert medications (HAM) are medications commonly used in health care settings that are associated with significant harm when used in error. Improvement in the knowledge and practice of pharmacists is crucial to prevent and solve medication errors associated with HAM. This study aimed to assess the knowledge of pharmacy students about HAM. Material and Method: A cross-sectional study was conducted among pharmacy students (3rd, 4th and 5th-year students) through an online survey in Ankara, Türkiye between 1 May 2021 and 31 October 2021. A Turkish translated and validated version of the High Alert Medications Knowledge Questionnaire was used. Only a correct answer was given score of 1 among the knowledge questions. The common resources for HAM use in the practice were assessed. Result and Discussion: Among 124 students, 80.6% were female. The mean age (standard derivation ± SD) of the students was 23.3 ± 1.37 years. The percentages of the 3rd, 4th and 5th-year students were 51.6%, 16.1% and 32.3%, respectively. The mean ± SD score of the students was 6.8 ± 3.28 out of 20. The 5th-year students (8.00 ± 2.90) were more likely to get higher scores compared to 3rd-years (5.89 ± 3.15) (p = 0.003). RxMediaPharma® (local online drug information database) was the most (75.0%) commonly used resource by pharmacy students. The pharmacy students\" knowledge about HAM was poor. Educational interventions are necessary early in the clinical pharmacy curriculum to improve pharmacy students\" knowledge and preparedness to handle HAM.