Person: TİGEN, ELİF
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TİGEN
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ELİF
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Publication Open Access Quality of life and related factors among chronic hepatitis B-infected patients: a multi-center study, Turkey(BMC, 2016-12) TİGEN, ELİF; Karacaer, Zehra; Cakir, Banu; Erdem, Hakan; Ugurlu, Kenan; Durmus, Gul; Ince, Nevin Koc; Ozturk, Cinar; Hasbun, Rodrigo; Batirel, Ayse; Yilmaz, Esmeray Mutlu; Bozkurt, Ilkay; Sunbul, Mustafa; Aynioglu, Aynur; Atilla, Aynur; Erbay, Ayse; Inci, Ayse; Kader, Cigdem; Tigen, Elif Tukenmez; Karaahmetoglu, Gokhan; Coskuner, Seher Ayten; Dik, Ebru; Tarakci, Huseyin; Tosun, Selma; Korkmaz, Fatime; Kolgelier, Servet; Karadag, Fatma Yilmaz; Erol, Serpil; Turker, Kamuran; Necan, Ceyda; Sahin, Ahmet Melih; Ergen, Pinar; Iskender, Gulsen; Korkmaz, Pinar; Eroglu, Esma Gulesen; Durdu, Yasemin; Ulug, Mehmet; Deniz, Suna Secil; Koc, Filiz; Alpat, Saygin Nayman; Oztoprak, Nefise; Evirgen, Omer; Sozen, Hamdi; Dogan, Mustafa; Kaya, Selcuk; Kaya, Safak; Altindis, Mustafa; Aslan, Emel; Tekin, Recep; Sezer, Busra Ergut; Ozdemir, Kevser; Ersoz, Gulden; Sahin, Ahmet; Celik, Ilhami; Aydin, Emsal; Bastug, Aliye; Harman, Rezan; Ozkaya, Hacer Deniz; Parlak, Emine; Yavuz, Ilknur; Sacar, Suzan; Comoglu, Senol; Yenilmez, Ercan; Sirmatel, Fatma; Balkan, Ilker Inanc; Alpay, Yesim; Hatipoglu, Mustafa; Denk, Affan; Senol, Gunes; Bitirgen, Mehmet; Geyik, Mehmet Faruk; Guner, Rahmet; Kadanali, Ayten; Karakas, Ahmet; Namiduru, Mustafa; Udurgucu, Hatice; Boluktas, Rukiye Pinar; Karagoz, Ergenekon; Ormeci, NecatiBackground: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors. Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant. Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided. Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.Publication Metadata only Outcomes of Fecal Carriage of Extended-spectrum beta-Lactamase After Transrectal Ultrasound-guided Biopsy of the Prostate(ELSEVIER SCIENCE INC, 2014) ERTÜRK ŞENGEL, BUKET; Tigen, Elif Tukenmez; Tandogdu, Zafer; Ergonul, Onder; Altinkanat, Gulsen; Gunaydin, Bilal; Ozgen, Mahir; Sariguzel, Nevin; Sengel, Buket Erturk; Odabasi, Zekaver; Cek, Mete; Tokuc, Resit; Turkeri, Levent; Mulazimoglu, Lutfiye; Korten, VolkanOBJECTIVE To determine the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (PE) fecal carriage in patients that undergo transrectal ultrasonography-guided biopsy (TRUSbx) and its relationship with post-biopsy infections. METHODS A prospective clinical study in 4 different tertiary hospitals between 2008 and 2010 was conducted. Four hundred men with sterile urine who were to undergo a TRUSbx because of the suspicion of prostate cancer were included and followed for 14 days after biopsy. Rectal swab culture specimens were acquired immediately before the procedure. Demographic data, prophylaxis choice, quinolone or any other antibiotic consumption within the past 2 months, history of prostatitis, repeat biopsy, intensive care unit admission, hospitalization, urethral catheterization, diabetes mellitus (DM), and steroid usage were recorded. RESULTS ESBL carriage was detected in 19% of patients and quinolone use within the last 2 months; other antibiotic use within the last 2 months and DM were found to be significantly associated (P < .05). Symptomatic urinary tract infection (UTI) on the third day after biopsy was seen in 9% of patients and was associated with fluoroquinolone (FQ) consumption before biopsy. Although ESBL-PE carriage was associated with post-biopsy UTI symptoms, it was not found to be associated with post-biopsy symptomatic UTI. Urosepsis was seen in 2 patients (0.5%) after biopsy, and both the patients were ESBL-PE carriers. CONCLUSION The presence of ESBL-PE was associated with DM and FQ consumption before biopsy. ESBL-PE carriage was associated with a high rate of post-biopsy UTI symptoms requiring further elucidation; however, it was not associated with microbiologically proven infections. FQ consumption before TRUSbx was also associated with post-biopsy infections. (C) 2014 Elsevier Inc.Publication Open Access Unusual causes of peritonitis in a peritoneal dialysis patient: Alcaligenes faecalis and Pantoea agglomerans(BMC, 2011) VELİOĞLU, ARZU; Kahveci, Arzu; Asicioglu, Ebru; Tigen, Elif; Ari, Elif; Arikan, Hakki; Odabasi, Zekaver; Ozener, CetinAn 87-year-old female who was undergoing peritoneal dialysis presented with peritonitis caused by Alcaligenes faecalis and Pantoea agglomerans in consecutive years. With the following report we discuss the importance of these unusual microorganisms in peritoneal dialysis patients.Publication Open Access The risk factors of colistin methanesulfonate associated nephrotoxicity(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2016-06) TİGEN, ELİF; Tigen, Elif Tukenmez; Koltka, E. Nursen; Dogru, Arzu; Gura, Melek; Vahabaoglu, HalukPurpose: The risk factors of colistin methanesulfonate (CMS) associated nephrotoxicity are important. Our study attempts look into the prevalence of CMS-associated nephrotoxicity in Intensive Care Units (ICUs), and related risk factors. Materials and Methods: The study was conducted between September 2010 and April 2012 on 55 patients who underwent CMS treatment. Nephrotoxicity risk was defined based on the Risk Injury Failure Loss End-stage kidney disease criteria. Results: Fifty-five patients included in the study. A total of 22 (40%) patients developed nephrotoxicity. The correlation was detected between nephrotoxicity and patients over 65 with a high Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) II score. APACHE II score was revealed an independent risk factor for nephrotoxicity. Conclusion: Advanced age and a high APACHE II score are significant risk factors in the development of nephrotoxicity at ICUs following CMS use. Patient selection and close monitoring are critical when starting CMS treatment.Publication Open Access The resistance rates of urinary tract infections: data from year 2010(2013-10-03) TİGEN, ELİF; Dogru, Arzu; Karatoka, Belma; Ergen, Pınar; Sen Aydın, Ozlem; Tukenmez Tigen, ElifPublication Metadata only Hepatitis B, Hepatitis C and human immunodeficiency virus prevalences among first time blood donors in Istanbul, Turkey, 2004-2011(PERGAMON-ELSEVIER SCIENCE LTD, 2015) TİGEN, ELİF; Tigen, Elif Tukenmez; Dogru, Arzu; Karadag, Fatma YilmazObjective: This study aims to determine the yearly change rates of the HBsAg, anti-HCV and anti-HIV test results and their positivity rates obtained from the 68,393 donors who applied and donated blood for the first time at the Blood Center of the hospital. Materials and Methods: Using the ELISA method, screening tests were applied to the blood samples obtained from blood donors, and the HBsAg, anti-HCV and anti-HIV positivity rates were calculated at the end of year eight. However, HBsAg and anti-HCV positivities showed a decreased tendency of positivity in years. Results: A total of 68,393 donations were received within eight years. Seroprevalences for anti-HIV, HBsAg and anti-HCV tests were, respectively 0.01%, 1.54% and 0.38%. HBsAg and anti-HCV positivities showed a decreased tendency of positivity in years. (C) 2015 Elsevier Ltd. All rights reserved.Publication Metadata only Extended-spectrum β-lactamases and their clinical importance in community-acquired infections [Toplum kökenli i̇nfeksiyonlarda genişlemiş spektrumlu β-laktamazlar ve klinik önemi](AVES Ibrahim Kara, 2012) TİGEN, ELİF; Tükenmez-Tigen E., Mülazimoǧlu L.Community-acquired extended-spectrum β-lactamase (ESBL) producing organisms cause life threatening infections, the majority of which are urinary tract infections and bacteremias caused by CTX-M enzyme producing Escherichia coli. Approach to these infections requires great care because their mortality rates are high unless timely and appropriate treatment is started.Publication Open Access Device-Associated Nosocomial Infection Rates and Distribution of Antimicrobial Resistance in a Medical-Surgical Intensive Care Unit in Turkey(NATL INST INFECTIOUS DISEASES, 2014) TİGEN, ELİF; Tigen, E. Tukenmez; Dogru, A.; Koltka, E. N.; Unlu, C.; Gura, M.The aim of this study was to explore the rate of device-associated nosocomial infections (DANIs) and the distributions of causative agents and patterns of antibiotic resistance in the medical-surgical intensive care unit (ICU) over a 3-year period and to compare these rates with those reported by National Nosocomial Infections Surveillance System and International Nosocomial Infection Control Consortium. A total of 1,798 patients were hospitalized in our ICU for 13,942 days, of which 309 patients had DANIs, indicating an overall infection rate of 22.1 per 1,000 ICU-days. The central line-associated bloodstream infection rate was 6.4 per 1,000 catheter-days, whereas the ventilator-associated pneumonia rate was 14.3 per 1,000 ventilator-days and the catheter-associated urinary tract infection rate was 4.3 per 1,000 catheter-days. Overall, 87.4% of all Staphylococcus aureus DANIs were caused by methicillin-resistant strains. With respect to Pseudomonas aeruginosa, 30.9% of the strains were resistant to ciprofloxacin, 23.3% to amikacin, 43.1% to ceftazidime, 19.1% to piperacillin-tazobactam, and 34.7% to imipenem. Furthermore, 1.9% of the Enterococcus spp. were resistant to vancomycin, and 51.1% of Enterobacteriaceae were resistant to ceftriaxone. DANI rates decreased over the 3-year study period, which was likely in response to the infection control measures implemented in our ICU.Publication Metadata only Prediction of unfavorable outcomes in cryptococcal meningitis: results of the multicenter Infectious Diseases International Research Initiative (ID-IRI) cryptococcal meningitis study(SPRINGER, 2018) TİGEN, ELİF; Hakyemez, I. N.; Erdem, H.; Beraud, G.; Lurdes, M.; Silva-Pinto, A.; Alexandru, C.; Bishop, B.; Mangani, F.; Argemi, X.; Poinot, M.; Hasbun, R.; Sunbul, M.; Akcaer, M.; Alp, S.; Demirdal, T.; Angamuthu, K.; Amer, F.; Ragab, E.; Shehata, G. A.; Ozturk-Engin, D.; Ozgunes, N.; Larsen, L.; Zimmerli, S.; Sipahi, O. R.; Tigen, E. Tukenmez; Celebi, G.; Oztoprak, N.; Yardimci, A. C.; Cag, Y.Cryptococcal meningitis (CM) is mostly seen in immunocompromised patients, particularly human immunodeficiency virus (HIV)-positive patients, but CM may also occur in apparently immunocompetent individuals. Outcome analyses have been performed in such patients but, due to the high prevalence of HIV infection worldwide, CM patients today may be admitted to hospitals with unknown HIV status, particularly in underdeveloped countries. The objective of this multicenter study was to analyze all types of CM cases in an aggregate cohort to disclose unfavorable outcomes. We retrospectively reviewed the hospitalized CM patients from 2000 to 2015 in 26 medical centers from 11 countries. Demographics, clinical, microbiological, radiological, therapeutic data, and outcomes were included. Death, neurological sequelae, or relapse were unfavorable outcomes. Seventy (43.8%) out of 160 study cases were identified as unfavorable and 104 (65%) were HIV infected. On multivariate analysis, the higher Glasgow Coma Scale (GCS) scores (p = 0.021), cerebrospinal fluid (CSF) leukocyte counts > 20 (p = 0.038), and higher CSF glucose levels (p = 0.048) were associated with favorable outcomes. On the other hand, malignancy (p = 0.026) was associated with poor outcomes. Although all CM patients require prompt and rational fungal management, those with significant risks for poor outcomes need to be closely monitored.Publication Metadata only Giant Purulent Pericarditis with Cardiac Tamponade Due to Streptococcus intermedius Rapidly Progressing to Constriction(WILEY-BLACKWELL, 2015) TİGEN, ELİF; Tigen, Elif T.; Sari, Ibrahim; Ak, Koray; Sert, Sena; Tigen, Kursat; Korten, VolkanPurulent pericardial effusion, although rare, is a life-threatening condition usually produced by the extension of a nearby bacterial infection locus or by blood dissemination in the immune-suppressed subjects or in the course of cardiothoracic surgery. Because clinical features of purulent pericardial effusion are often nonspecific, it can cause delay in diagnosis. Therefore, a high index of suspicion is required for timely diagnosis and management. Herein, we describe a case of giant purulent pericardial effusion due to Streptococcus intermedius with the history of bronchiectasis and pneumonia, which was successfully treated with pericardiocentesis via parasternal approach, appropriate antibiotics, and pericardiectomy. Mini-Abstract Purulent pericardial effusion, although rare, is a life-threatening condition usually produced by the extension of a nearby bacterial infection locus or by blood dissemination in the immune-suppressed subjects or in the course of cardiothoracic surgery. Because clinical features of purulent pericardial effusion are often nonspecific, it can cause delay in diagnosis. Therefore, a high index of suspicion is required for timely diagnosis and management. Herein, we describe a case of giant purulent pericardial effusion due to Streptococcus intermedius with the history of bronchiectasis and pneumonia, which was successfully treated with pericardiocentesis via parasternal approach, appropriate antibiotics, and pericardiectomy.