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DUMAN, DENİZ

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DUMAN

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DENİZ

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2010 - 20162
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Subject: METABOLIC SYNDROME ×

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    Microalbuminuria in nondiabetic patients with nonalcoholic fatty liver disease: association with liver fibrosis
    (W B SAUNDERS CO-ELSEVIER INC, 2010) ÇELİKEL, ÇİĞDEM; Yilmaz, Yusuf; Alanhdab, Yesim Ozen; Yonal, Oya; Kurt, Ramazan; Kedrah, Alla Eldeen; Celikel, Cigdem Ataizi; Ozdogan, Osman; Duman, Deniz; Imeryuz, Nese; Avsar, Erol; Kalayci, Cem
    Recent evidence has suggested an association between microalbuminuria and ultrasound-diagnosed nonalcoholic fatty liver disease (NAFLD) in patients with diabetes and prediabetes However, few data are available on the occurrence of microalbuminuria in nondiabetic subjects with histologically proven NAFLD We thus evaluated the relationships between microalbuminuria and liver histology in a hospital-based sample of 87 adults with biopsy-proven NAFLD from Turkey An albumin excretion rate less than 30 mg/d was considered within the reference range, whereas an albumin excretion rate from 30 to 300 mg/d was considered to indicate microalbuminuria Compared with those without microalbuminuria (n = 73), NAFLD patients with microalbuminuria (n = 14) had significantly higher homeostasis model assessment of insulin resistance values (3 9 +/- 1 3 vs 5 8 +/- 3 7, P < 001) There were no differences in the prevalence of microalbuminuria in patients with definite nonalcoholic steatohepatitis, borderline nonalcoholic steatohepatitis, and simple fatty liver In the entire study cohort, mean fibrosis scores were significantly higher in patients with microalbuminuria than in those without (1 27 +/- 0.26 vs 0 80 +/- 0 11, P < 05) This difference persisted after adjustment for potential confounders These results indicate the presence of a significant association between the seventy of insulin resistance and microalbuminuria in patients with NAFLD In addition, microalbuminuria may identify NAFLD patients with higher fibrosis scores (C) 2010 Elsevier Inc. All rights reserved
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    Nonalcoholic Fatty Liver Disease is Associated With Erectile Dysfunction: A Prospective Pilot Study
    (ELSEVIER SCI LTD, 2016) ÇELİKEL, ÇİĞDEM; Duman, Deniz Guney; Bicakci, Ercan; Celikel, Cigdem Ataizi; Akbal, Cem
    Introduction: Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Although the link between MetS and erectile dysfunction (ED) is well known, clinical studies investigating the association between NAFLD and ED are scant. Aim: To evaluate the relationship between NAFLD and ED. Methods: Male patients with biopsy-proven NAFLD were prospectively asked to fill the five-item International Index of Erectile Function (IIEF-5) questionnaire. Their clinical and histologic variables were compared with the IEFF scores. Main Outcome Measures: IIEF scores; proportions of NAFLD patients who demonstrated ED and/or MetS; association between the severity of histological hepatic damage and ED. Results: Forty male patients having an age range of 33 (24-57) and a mean age of 40.13 +/- 10.22 years with biopsy-proven NAFLD had a median IIEF-5 score of 16 (9-25) and MetS was present in 23 (57.5%). ED severity distributions as moderate, mild, and no ED were 11 (27.5%), 16 (40%), and 13 (32.5 %), respectively. Histological NAFLD score was significantly higher in patients having ED compared with patients with no ED (5.63 +/- 1.39 vs 4.15 +/- 1.46; P = .006). MetS diagnosis was significantly more common in patients having ED, compared with those without ED [19 (70.4%) vs 4 (30.8%), respectively, P = .018)]. When patients with and without ED were compared, gamma glutamyl transferase was significantly lower in ED, whereas components of MetS did not correlate with ED. After multivariate analysis, NAFLD score has remained the only significant outcome associated with ED [P = .03; OR (95% CI): 2.38 (1.079-5.238)]. Conclusion: The current clinical study demonstrates a significant association between nonalcoholic steatohepatitis and ED for the first time. Our findings suggest liver damage may play role in the pathogenesis of ED in patients with NAFLD. Future studies are needed to expand the underlying common mechanisms responsible for this novel hypothesis. Copyright (C) 2016, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.