Person: HAZNEDAROĞLU, EDA
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HAZNEDAROĞLU
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Publication Open Access A 48-month randomized controlled trial of caries prevention effect of a one-time application of glass ionomer sealant versus resin sealant(JAPANESE SOC DENTAL MATERIALS DEVICES, 2016) MENTEŞ, ALİ RECAİ; Haznedaroglu, Eda; Guner, Sirin; Duman, Canan; Mentes, AliThe aim of this study was to compare the caries prevention effectiveness, retention rates and the level of fluoride of saliva of a glass-ionomer sealant (GIS) with that of a resin-based sealant (RS). Eighty GIS and 80RS were placed on the first permanent molars in 40 children aged 7-10 years. Children were re-examined at 6, 12, 24, 36 and 48 months after the procedure. Saliva samples were collected before the sealant was applied and again at each appointment, and fluoride levels were measured. After 48 months, occlusal caries were seen in 4 and 12 teeth in GIS and RS groups respectively. There was a statistically significant difference in the fluoride levels of saliva between baseline and up to 12th month in GIS group. GISs presented effective prevention of caries development, even though the failure rate is higher when compared to the RSs. An increased salivary fluoride level due to GISs might be an additive effect on the prevention of dental caries.Publication Open Access The Internet versus pediatricians as a source of infant teething information for parents in Turkey(HOSPITAL CLINICAS, UNIV SAO PAULO, 2016-08-03) MENTEŞ, ALİ RECAİ; Haznedaroglu, Eda; Mentes, AliOBJECTIVES: Parents are increasingly searching the Internet to gather information about their children's health care. This study compared infant teething information obtained from publically employed pediatricians in Istanbul with that obtained from different Turkish websites (parenting, health, professional, news and commercial). METHODS: This study had two parts. The first part used a descriptive design, with two checklists to assess the quality and comprehensiveness of the teething-specific content on 62 parenting or health websites. The second part was a cross-sectional study of 75 pediatricians at public hospitals who completed a structured self-administered questionnaire. RESULTS: In total, 54 websites (87.1%) described infant teething as a normal developmental process. The lists that were found on the websites identified the most frequent signs of infant teething as fever and drooling/perioral rash. The most frequent management strategies were chewing non-chilled and chilled objects. For teething problems, some pediatricians recommended teething rings and oral benzocaine, while 23 pediatricians recommended nothing. CONCLUSIONS: Parents should be informed by health professionals, especially regarding specific treatment strategies.Publication Metadata only Two-fold excess of fluoride in the drinking water has no obvious health effects other than dental fluorosis(ELSEVIER GMBH, 2018) MENTEŞ, ALİ RECAİ; Sezgin, Batin Ilgit; Onur, Sirin Guner; Mentes, Ali; Okutan, Alev Eda; Haznedaroglu, Eda; Vieira, Alexandre RezendeBackground. There is concern that fluorides in the drinking water is hazardous to health. Methods: We conducted an observational study in the village of Hanliyenice (population 280), Turkey, which has 2.5 times higher than optimal levels of fluoride in the drinking water and evaluated all children 7-13 years of age (N = 30). We collected information on dental decay, fluorosis, daily water consumption and diet, child history and her family history of cancer, cardiovascular risks/diseases, and asthma, and obtained a blood sample for extraction of genomic DNA. We genotyped ten single nucleotide polymorphisms in aquaporins. Results: As expected, a high number of children were dental caries free (19 out of 30) and had fluorosis (25 out of 30). Family history of cancer, cardiovascular events, and asthma was not different from the expected figures based on Turkey. One variant just upstream of AQP5 was associated with being fluorosis free. (G allele of AQP5 rs296763, p = 6.0E(-6)). Conclusions: Exposure to levels of fluoride twice as high than the optimum in the drinking water increases the prevalence of fluorosis, dramatically decreases dental caries, and does not increase the risk of cancer, cardiovascular events, and asthma.Publication Metadata only Association of Sweet Taste Receptor Gene Polymorphisms with Dental Caries Experience in School Children(KARGER, 2015) MENTEŞ, ALİ RECAİ; Haznedaroglu, Eda; Koldemir-Gunduz, Meliha; Bakir-Coskun, Nur; Bozkus, Hasan M.; Cagatay, Penbe; Susleyici-Duman, Belgin; Mentes, AliSweet taste is a powerful factor influencing food acceptance. The peripheral taste response to sugar is mediated by the TAS1R2/TAS1R3 taste receptors. The aim of the study was to determine the relationship between TAS1R2 (rs35874116 or rs9701796) and/or TAS1R3 (rs307355) single nucleotide polymorphisms with dental caries experience in schoolchildren. A total of 184 schoolchildren aged between 7 and 12 years (101 girls, 83 boys) were included in the study. Genomic DNA was extracted from saliva samples and the genotypes were identified by qPCR. The genotype frequencies were as follows: 6.6% for homozygous wild type, 41.8% for heterozygous and 51.6% for homozygous polymorphic genotype carriers of TAS1R2 gene rs35874116; 27.8% for heterozygous and 72.2% for homozygous polymorphic genotype carriers of TAS1R2 gene rs9701796, and 83.1% for homozygous wild type and 16.9% for heterozygous genotype carriers of TAS1R3 gene rs307355 polymorphism. A significant association was observed between total caries experience (dft + DMFT - decayed filled primary teeth + decayed, missing and filled permanent teeth) and TAS1R2 rs35874116 (p = 0.008) and TAS1R3 rs307355 (p = 0.04) gene polymorphisms but not for TAS1R2 gene rs9701796 polymorphism. TAS1R3 gene rs307355 polymorphism has been found to be an independent risk factor for dental caries experience by logistic regression analysis and to have increased the risk of caries. Moderate caries experience (4-7 caries) was found to be associated with TAS1R3 rs307355 heterozygous genotype, whereas high-risk caries experience (>8 caries) was found to be associated with TAS1R2 rs35874116 homozygous polymorphic genotype. (C) 2015 S. Karger AG, BaselPublication Metadata only Dental Fluorosis and Catalase Immunoreactivity of the Brain Tissues in Rats Exposed to High Fluoride Pre- and Postnatally(HUMANA PRESS INC, 2016) MENTEŞ, ALİ RECAİ; Guner, Sirin; Uyar-Bozkurt, Suheyla; Haznedaroglu, Eda; Mentes, AliThis study evaluated dental fluorosis of the incisors and immunoreactivity in the brain tissues of rats given chronic fluoride doses pre- and postnatally. Female rats were given drinking water with 0, 30 or 100 ppm fluoride ad libitum throughout gestation and the nursing period. In addition, 63 male offspring were treated with the same water regimens as the mothers after weaning and were followed for 1, 3 or 5 months. The upper and lower incisors were collected, and all teeth were examined under a stereomicroscope and scored by two blinded examiners using a modified rodent enamel fluorosis index. Cortical, hippocampal and cerebellar brain samples were evaluated morphologically and immunohistochemically. All fluoride-treated pups were born with low body weight (p = 0.001). All animals from the fluoride groups had enamel fluorosis with defects of various degrees. The increase in the dental fluorosis scores in the fluoride treatment groups was significant (p < 0.01). The catalase immunoreactivity in the 30- and 100-ppm fluoride groups was significantly higher than that in the controls after 1, 3 and 5 months (p < 0.001). In conclusion, this study showed that rats with dental fluorosis had catalase immunoreactivity in the brain tissues, which may reflect the neurobehavioral toxicity of fluoride.Publication Open Access Edirne’nin içme suyu fluor oranı farklı 3 ilçesinde dental fluorozis ve diş çürüğü prevalansının değerlendirilmesi(2019) MENTEŞ, ALİ RECAİ; ŞİRİN GÜNER ONUR;Batın Ilgıt SEZGİN;CEM TOKATLI;EDA HAZNEDAROĞLU;Alev Eda OKUTAN;Gökçe Çiçek İLDEŞ;ELİF ECE KALAOĞLU;Belgin YAZICI;ALİ RECAİ MENTEŞAmaç: Çalışmamızda Edirne’nin 3 ilçesinde içme sularındakifluor seviyeleri belirlenerek bölgede yaşayan çocuklarda dentalfluorozis ve diş çürüğü görülme sıklığı değerlendirilmiştir.Gereç ve Yöntem: Edirne ilinde, Kuzey Havsa, Süloğlu veLalapaşa ilçe merkezleri ve köylerinden içme suyu örnekleritoplanmıştır. İçme sularındaki fluor miktarları iyon spesifik Felektrodu (Orion 960900 Fluoride Combination Electrode,Thermo Scientific) kullanılarak ölçülmüştür. Bu bölgedekiçocuklarda diş çürükleri DMFT/dft indeksi kullanılarak dentalfluorozis ise Thylstrup-Fejerskov (TF) indeksi kullanılarak incelenmiştir.Bölge, içme sularındaki fluor oranlarına göre grup1: <0,5 ppm (F1), grup 2: 0,5-1,2 ppm (F2) ve grup 3: 2,39 ppm(F3) şeklinde gruplandırılmıştır. Toplanan tüm veriler SPSS21v istatistik programı kullanılarak değerlendirilmiştir.Bulgular: Araştırmaya toplam 231 çocuk (%55 erkek %45 kız;yaş ortalaması 9,89±1,68) dahil edilmiştir. F1 grubunda 146(%63,2); F2 grubunda 51 (%22,1); F3 grubunda 34 (%14,7)çocuk bulunmaktadır. İçme suyundaki fluor miktarı ile dentalfluorozis ilişkisine bakıldığında F1, F2, F3 gruplarının TF ortalamaları0,39±0,88; 0,33±0,71; 3,56±2,64 olarak tespit edilmişolup F1, F2, F3 grupları arasında istatistiksel olarak anlamlıfark bulunmuştur (p=0,000). İçme suyundaki fluor ile diş çürüğüilişkisine bakıldığında F1, F2, F3 gruplarında DMFT/dft ortalamaları5,27±3,39; 3,55±3,60; 2,35±2,65 olarak bulunmuşolup gruplar arasında istatistiksel olarak anlamlı fark izlenmiştir(p=0,000).Sonuç: İçme suyundaki fluor seviyesini artması ile çocuklardadental fluorozis şiddetinin arttığı gözlenmiştir. Çürük prevalansınınyüksek bulunduğu bölgelerde sistemik fluorun çürüktenkorunmada bir miktar etkili olduğu ancak özellikle süt dentisyondabeklenen etkisinin olmadığı görülmüştür. Çalışmamızbir kez daha sistemik fluorun çürükten korunmada tek başınayetersiz olabileceğini göstermiştir.Publication Open Access Retrospective evaluation of traction time for impacted dilacerated maxillary central incisors in mixed dentition(2023-04-01) ŞEN YAVUZ, BETÜL; YILMAZ, MÜESSER AHU; HAZNEDAROĞLU, EDA; UĞURLU, FAYSAL; MENTEŞ, ALİ RECAİ; Şen Yavuz B., Yılmaz M. A., Haznedaroğlu E., Sezer B., Okutan A. E., Sezgin B. I., Özçelik M., Sezgin G. İ., Uğurlu F., Menteş A. R.PurposesThis study aimed to contribute to understanding the factors affecting the time of traction treatment of impacted dilacerated maxillary central incisors.MethodsThis retrospective study included children aged 8 – 11 years with a history of trauma, who applied to the pediatric dentistry clinics of Marmara University, School of Dentistry, between December 2013 and December 2019, and were treated for unilateral impacted dilacerated maxillary upper central incisors. Children\"s age, sex, digital panoramic radiographs, cone-beam computed tomography, and intraoral photographs were retrieved from electronic dental health records. The effects of children\"s age, sex, the direction of impacted teeth, distance of the teeth to the top of the alveolar crest, and root dilaceration level on traction time were analyzed by Mann-Whitney U test and Spearman\"s rank correlation coefficient test.ResultsThe inverse position of the incisors significantly increased the traction time (P = 0.012). However, the traction time did not differ according to the sex of the children (P = 0.707) or the level of root dilaceration (P = 0.429). No correlation was observed between the traction time and the age of children (P = 0.644) or the distance of the incisors from the top of the alveolar crest (P = 0.397).ConclusionsIn cases of the forced eruption of for the impacted dilacerated maxillary central incisors, the direction of the teeth should be evaluated when deciding on the treatment plan, as it may affect the treatment time.Publication Metadata only Katepsin C gen mutasyonuyla ilişkili agresif periodontitisli iki kardeşin ağız içi bulguları(2020-01-09) YILDIRIM, HATİCE SELİN; HAZNEDAROĞLU, EDA; MENTEŞ, ALİ RECAİ; ELÇİOĞLU, HURİYE NURSEL; GÜNGÖRMEK H. S., HAZNEDAROĞLU E., MENTEŞ A. R., ÖZEMRİ SAĞ Ş., ZEYBEK S., TEMEL Ş. G., ELÇİOĞLU H. N.Publication Metadata only Pedodontide postoperatif ağrı(Ankara: Türkiye Klinikleri, 2023-01-01) MENTEŞ, ALİ RECAİ; HAZNEDAROĞLU, EDA; MENTEŞ A. R., HAZNEDAROĞLU E.