Person: ŞİRVANCI, SERAP
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ŞİRVANCI
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SERAP
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Publication Metadata only Primer siliyer diskinezi tanısında transmisyon elektron mikroskopi(Türkiye Klinikleri, 2022-01-01) KAYA, ÖZLEM TUĞÇE; ŞİRVANCI, SERAP; ŞİRVANCI S., KAYA Ö. T.Primer siliyer diskinezi (PSD), siliya fonksiyon bozukluğunun neden olduğu, çoğunlukla otozomal resesif geçişli, klinik ve genetik olarak heterojen bir hastalıktır. PSD klinik fenotipi değişkendir. Üst ve alt solunum sistemi, üreme organları, kalp ve siliyaların bulunduğu diğer sistemleri tutar. Zamanında doğan PSD'li bebeklerin yaklaşık %80'i, doğum sonrası 24 saat içinde solunum sıkıntısı kliniği gösterir ve oksijen desteği gerektirir. Sonraki dönemde tekrarlayan pnömoni veya bronşit yaygın görülür. Kronik, efüzyonlu tekrarlayan orta kulak iltihabı, özellikle yaşamın ilk yılında, PSD'li çocukların en az %80'ini etkiler. Hastaların yaklaşık %80'inde yıl boyu devam eden burun tıkanıklığı ve kronik sinüzit vardır. Situs inversus totalis daha sık olmak üzere bir dizi organ lateralite kusuru görülür. Erkeklerde infertilite, kadınlarda ektopik gebelik sıktır. Bazı durumlarda, PSD'nin polikistik böbrek, hidrosefali, polispleni gibi nadir ve olağandışı bozukluklarla ilişkili olduğu gösterilmiştir. Son zamanlarda genetik çalışmaların hızlanmasıyla yapılan çalışmalar, farklı genlerdeki mutasyonların değişken fenotiplere yol açtığını göstermektedir. Bununla ilgili vaka serileri mevcuttur.Publication Metadata only The ameliorative effects of melatonin on acetic acid-induced gastric ulcer in rats via its modulatory effects on gut microbiota(CUKUROVA UNIV, FAC MEDICINE, 2021) YILDIRIM, ALPER; Tamer, Sevil Arabaci; Yildirim, Alper; Cevik, Ozge; Aksu, Burak; Yuksel, Meral; Dertsiz, Ekin Kuntsal; Sirvanci, Serap; Yegen, Berrak C.Purpose: The aim of this study was of observe the possible protective effects of melatonin pretreatment on oxidative damage and microbiota alteration due to gastric ulcer in rats. Materials and Methods: Wistar-albino rats were given (n=32) melatonin (4 mg/kg/day), antibiotic mixture (AB; 1g/L ampicillin + 1g/L neomycin + 1g/L metronidazole), melatonin+AB in drinking water for 12 days or tap water for 15 days (control group; n=8). Subsequently, ulcer was induced. All treatments were continued for three days. Gastric tissues were obtained for biochemical and histopathological examinations, and fecal samples from the rectum were stored for bacteriological measurements. Results: MPO and MDA levels were increased in untreated ulcer groups compared to the control group. In addition, the levels of luminol-lucigenin chemiluminescence (CL) and 8-OHdG and TNF-alpha and IL-8 protein expressions were also increased, while TNF-alpha, IL-8, MDA, 8-OHdG, luminol and lucigenin CL levels were significantly decreased in the melatonin-treated ulcer groups. However, melatonin+AB pretreatment increased antioxidant GSH levels and anti-inflammatory IL-10 levels, and suppressed caspase-3 activity and reduced MPO back to control level. Conclusion: We anticipate that melatonin treatment, which is an effective antioxidant and radical scavenger, can accelerate ulcer healing along with antibiotics and increase the variety of bacteria impaired by antibiotics in the colon.Publication Metadata only Effect of Tacrolimus on Peripheral Nerve Regeneration in Allograft Transplantation: A Light and Electron Microscopic Study(2021) KAYA, ÖZLEM TUĞÇE; Cilingir-Kaya, Ozlem Tugce; Sumer, Onur; Sirvanci, Serap; Gurler, Esra Bihter; Akcal, Arzu; Karsidag, SemraOBJECTIVES: Peripheral nerve injuries are common in Europe; however, the treatment techniques may lead to disabilities. This study aimed to evaluate the effect of tacrolimus use on the capacity of the epineural sheath graft to improve its regeneration quality in rat sciatic nerves as a treatment option for nerve injuries. MATERIALS AND METHODS: In the experimental process, 30 male Sprague Dawley were used as recipients and 10 Wistar rats were used as donors. Under anesthesia, all rats were operated on to resect the sciatic nerve. The nerve tissue of Wistar rats was used as allograft. In the autograft group, the resected nerve was reversed and sutured, resulting in an epineural sheath graft. For the allograft groups, rats were randomly divided into 2 groups as the tacrolimus-treated group and the nontreated group after allograft transplant. Tacrolimus was administered intramuscularly at 0.1 mg/kg daily for 12 weeks. After the treatment period, rats were killed and evaluated histomorphologically with light and electron microscopy. RESULTS: Histological examination showed no remarkable differences between different regions of the sciatic nerves (distal, middle, and proximal). The axonal density was decreased in the allograft groups compared with the autograft group (P < .001). Results showed that the number of mast cells was increased in the allograft group without tacrolimus treatment (P < .05). Similarly, there was a mild increase in mast cell count in the tacrolimus-treated allograft group. CONCLUSIONS: Our results showed that tacrolimus use in rats with implanted epineural nerve sheath supported recovery in terms of morphological and physiological regeneration of the nerve.Publication Metadata only İntrakardiyak perfüzyon(Ankara Nobel Tıp kitabevleri, 2021-01-01) ŞİRVANCI, SERAP; ŞİRVANCI S.Publication Metadata only alpha 7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats(ELSEVIER, 2021) ARICIOĞLU, FEYZA; Unal, Gokhan; Sirvanci, Serap; Aricioglu, FeyzaThe majority of schizophrenia patients have cognitive deficits as a separate symptom cluster independent of positive or negative symptoms. Current medicines, unfortunately, cannot provide clear benefits for cognitive symptoms in patients. Recent findings showed decreased alpha 7 nicotinic acetylcholine receptor (nAChR) expressions in subjects with schizophrenia. alpha 7 nAChR full/partial agonists and positive allosteric modulators (PAMs) may be valuable drug candidates to treat cognitive deficits of disease. This study comparatively investigated the effect of alpha 7 nAChR agonist (A-582941), type I PAM (CCMI), type II PAM (PNU-120596), and the antipsychotic drug (clozapine) on behavioral, molecular, and immunohistochemical parameters in a subchronic MK-801 model of schizophrenia in male rats. Novel object recognition (NOR) and Morris water maze (MWM) tests were performed to evaluate recognition and spatial memories, respectively. Gene and protein expressions of parvalbumin, glutamic acid decarboxylase-67 (GAD67), and alpha 7 nAChR were examined in the rats' hippocampal tissue. The subchronic MK-801 administration produced cognitive deficits in the NOR and MWM tests. It also decreased the protein and gene expressions of parvalbumin, GAD67, and alpha 7 nAChR in the hippocampus. Clozapine, A-582941, and PNU-120596 but not CCMI increased the parvalbumin and alpha 7 nAChR expressions and provided benefits in recognition memory. Interestingly, clozapine and CCMI restored the MK-801 induced deficits on GAD1 expression and spatial memory while A-582941 and PNU-1 20 596 were ineffective. These results indicated that alpha 7 nAChR agonist, type I and type II PAMs may provide benefits in different types of cognitive deficits rather than a complete treatment in schizophrenia.Publication Metadata only Ultrastructural GABA immunogold labeling in the substantia nigra pars reticulata of kindled genetic absence epilepsy rats(TAYLOR & FRANCIS INC, 2020) AKAKIN, DİLEK; Sirvanci, Serap; Akakin, Dilek; Idrizoglu, Medine Gulcebi; Kaya, Ozlem Tugce; Karamahmutoglu, Tugba; Asik, Zehra Nur Turgan; Onat, FilizGenetic Absence Epilepsy Rats from Strasbourg (GAERS) is a well-known animal model of absence epilepsy and they are resistant to electrical kindling stimulations. The present study aimed to examine possible differences in gamma-aminobutyric acid (GABA) levels and synapse counts in the substantia nigra pars reticulata anterior (SNRa) and posterior (SNRp) regions between GAERS and Wistar rats receiving kindling stimulations. Animals in the kindling group either received six stimulations in the amygdala and had grade 2 seizures or they were kindled, having grade five seizures. Rats were decapitated one hour after the last stimulation. SNR regions were obtained after vibratome sectioning of the brain tissue. GABA immunoreactivity was detected by immunogold method and synapses were counted. Sections were observed by transmission electron microscope and analyzed by Image J program. GABA density in the SNRa region of fully kindled GAERS and Wistar groups increased significantly compared to that of their corresponding grade 2 groups. The number of synapses increased significantly in kindled and grade 2 GAERS groups, compared to kindled and grade 2 Wistar groups, respectively, in the SNRa region. GABA density in the SNRp region of kindled GAERS group increased significantly compared to that of GAERS grade 2 group. In the SNRp region, both kindled and grade 2 GAERS groups were found to have increased number of synapses compared to that of GAERS control group. We concluded that both SNRa and SNRp regions may be important in modulating resistance of GAERS to kindling stimulations.Publication Metadata only Histological analysis of the effects of thymoquinone on testicular damage in pentylenetetrazole-induced temporal lobe epilepsy model(WILEY, 2021) ŞİRVANCI, SERAP; Karakaya, Fatma Bedia; Yavuz, Melis; Sirvanci, SerapIn this study, it was aimed to investigate possible ameliorating effects of thymoquinone on testicular damage in an epilepsy model. Adult male Wistar rats were divided into 4 groups. The animals in sham-operated groups were given saline or thymoquinone (s.c.); and the animals in pentylenetetrazole (PTZ) group were applied PTZ. The animals in PTZ+thymoquinone group were given thymoquinone (i.p) for 6 days after applying PTZ. Hematoxylin-eosin, periodic acid-Schiff and TUNEL staining and PCNA, StAR, inhibin beta-B immunohistochemistry and ZO-1 immunofluorescence methods were applied. Staining intensity and cell numbers were determined. Degeneration of seminiferous tubules was observed in PTZ group. Most of the tubules showed normal morphology in the PTZ+thymoquinone group. Apoptotic cell index was found to be increased and proliferative index decreased in PTZ group. Thymoquinone administration decreased apoptotic index and increased proliferation index. In PTZ group, ZO-1, StAR and inhibin beta-B immunohistochemical staining intensity was observed to be decreased and after thymoquinone application, ZO-1 was increased. StAR and inhibin beta-B-positive cell numbers were decreased in PTZ group and increased in the PTZ +thymoquinone group. In this study, it was observed that PTZ-induced epileptic seizures caused testicular damage in the rat and thymoquinone ameliorated these effects.Publication Metadata only Epilepside mikroskopik yapıların görüntülenmesi(Nobel Tıp Kitabevleri, 2022-01-01) ŞEHİRLİ, ÜMİT SÜLEYMAN; ŞİRVANCI, SERAP; ŞEHİRLİ Ü. S., ŞİRVANCI S.