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YAKUT, NURHAYAT

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2016 - 20183
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Author: ÜLGER, NURVER ×

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    PublicationOpen Access
    Hospital acquired Clostridium difficile infection in pediatric wards: a retrospective case-control study
    (SPRINGER INTERNATIONAL PUBLISHING AG, 2016-12) ÜLGER, NURVER; Karaaslan, Ayse; Soysal, Ahmet; Yakut, Nurhayat; Akkoc, Gulsen; Demir, Sevliya Ocal; Atici, Serkan; Toprak, Nurver Ulger; Soyletir, Guner; Bakir, Mustafa
    Background: Clostridium difficile is a major cause of antibiotic-associated diarrhea and frequently results in health-care-associated infections. The aim of this study was to determine the incidence and potential risk factors for C. difficile infection (CDI) in hospitalized children who developed diarrhea. A retrospective study was performed at a university hospital in Istanbul over a three-year period (2012-2014). Results: During the study period 12,196 children were hospitalized, among them 986 (8 %) children with diarrhea were investigated for CDI and 100 (0.8 %) children were diagnosed with CDI. The incidence of CDI in hospitalized children was 4/1000, 9/1000 and 9/1000 patients per year in year 2012, 2013 and 2014, respectively (p = 0.008, p < 0.01). The mean age of children with CDI (2.6 +/- 2.6 months) was lower than children without CDI (57.5 +/- 63.5 months) [p = 0.001]. In the multivariate analysis, the presence of underlying chronic diseases [presence of malnutrition (OR 7, 95 % CI 1.33-36.7, p = 0.021), presence of solid organ tumors (OR 6, 95 % CI 2.4-15.7, p < 0.00), presence of congenital heart diseases (OR 4.6, 95 % CI 1.13-18.7, p = 0.03), hospitalization in PICU (OR 15.6, 95 % CI 3.2-75.8, p = 0.001) and hospitalization in hematology and oncology ward (OR 7.8, 95 % CI 2-29.9, p = 0.002)] were found to be independent risk factors for CDI. Conclusion: This is the first description of the incidence and associated risk factors of CDI in Turkish children. One of the most important risk factor was prior antibiotic exposure which emphasizes the importance of antibiotic stewardship programs.
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    PublicationOpen Access
    A rare and emerging pathogen: Raoultella planticola identification based on 16S rRNA in an infant
    (ELSEVIER SCIENCE LONDON, 2018-01) MEMİŞOĞLU, ASLI; Atici, Serkan; Unkar, Zeynep Alp; Demir, Sevliya Ocal; Akkoc, Gulsen; Yakut, Nurhayat; Yilmaz, Serife; Erdem, Kubra; Memisoglu, Asli Cinar; Ulger, Nurver; Soysal, Ahmet; Ozek, Eren; Bakir, Mustafa
    Raoultella planticola is rarely associated with clinical infection, and a limited number of pediatric cases have been reported. Herein we report a case of bacteremia presumptively secondary to bilateral conjunctivitis in an infant caused by R. planticola which was successfully treated with piperacillin-tazobactam. It should be kept in mind that R. planticola can be a pathogen in pediatric age groups. (C) 2017 The Authors. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license
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    PublicationOpen Access
    Lactococcus lactis spp lactis infection in infants with chronic diarrhea: two cases report and literature review in children
    (2016-03-31) KEPENEKLİ KADAYİFCİ, EDA; Karaaslan, Ayse; Soysal, Ahmet; Kepenekli Kadayifci, Eda; Yakut, Nurhayat; Ocal Demir, Sevliya; Akkoc, Gulsen; Atici, Serkan; Sarmis, Abdurrahman; Ulger Toprak, Nurver; Bakir, Mustafa
    Lactococcus lactis is a gram-positive, facultative anaerobic coccus that is occasionally isolated from human mucocutaneous surfaces such as the intestines. It is used in the dairy industry for milk acidification and is mostly nonpathogenic in immunocompetent humans, however a number of cases of infection with L. lactis have been reported in recent years. In this article, we describe two cases of infection due to L. lactis in patients with chronic diarrhea. The first case is a five-month-old boy who was operated on for volvulus on his first day of life and had ileostomy with subsequent diagnosis of chronic diarrhea and bacteremia due to L. Lactis. The second case is a six-month-old girl with the diagnosis of chronic diarrhea that developed after a catheter-related bloodstream infection. Both of the infections due to L. Lactis spp lactis were successfully treated with intravenous vancomycin therapy. Although Lactococcus species is mostly known as nonpathogenic, it should be kept in mind as a potential pathogen, especially in patients with gastrointestinal disorders.