Person: GÜNEŞ, FATMA ESRA
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GÜNEŞ
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FATMA ESRA
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Publication Metadata only Nutrients in schizophrenia: A focus on the pathophysiological pathway(Pacini Editore S.p.A./AU-CNS, 2021) GÜNEŞ, FATMA ESRA; Akduman G., Kurtbeyoglu E., Gunes F.E.Objectives The aim of this article is to explain the nutrients that play an active role in the pathophysiology of schizophrenia. Methods This paper is a narrative literature review of relevant articles and prior works that have been central to the topic including the active nutrients in the pathophysiology of schizophrenia. Results The findings are compiled under six headings. The changes in the antioxidant defense system, dopamine pathway, serotonin pathway, gamma-aminobutyric acid (GABA) pathway, glutamate pathway, the endocannabinoid system, and metabolomic profile were investigated in relation to nutrients. Conclusions This review provides an update of scientific knowledge on the growing role of nutrition in schizophrenia. Nutrient deficiencies that occur frequently in these patients should be followed and eliminated to ensure the correct functioning of the pathophysiological pathways of the disease. © 2021 Pacini Editore S.p.A.. All rights reserved.Publication Metadata only Nutritional label use among patients with type 1 diabetes mellitus(Romanian Society of Diabetes, Nutrition and Metabolic Diseases, 2021) CEBECİ, AYBİKE; Cebeci A., Aktac S., Keskin S., Senguzel S., Gunes F.E.Background and Aims: In this study, it was aimed to evaluate the nutritional label use of individuals with type 1 DM. Material and Method: This cross-sectional descriptive study was conducted in November 2017 - June 2018. Diabetic individuals were reached through hospitals and social networks. The study was conducted with 105 (64 female, 41 male) individuals with type 1 DM living in Istanbul. A questionnaire about sociodemographic characteristics, biochemical parameters, medical treatment, food label reading status, food label reading reasons were applied in the study. Data were analyzed using SPSS V 16.0 program. Results: 85.7% of the participants read the food label. No significant difference was found when age group and nutritional label reading status were examined (p > 0.05). Besides, information was given to 67.6% of the participants about reading the nutritional label. A significant association was found between nutritional label reading knowledge and carbohydrate counting application and stages (P=0.0001). However, there was no significant difference between biochemical parameters and reading label status (p>0.05). Conclusions: Nutritional label reading should be mentioned more in the medical nutrition therapy and diabetes education. © 2021 The Authors. Romanian Journal of Diabetes, Nutrition and Metabolic Diseases published by Sanatatea Press Group on behalf of the Romanian Society of Diabetes Nutrition and Metabolic Diseases. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY-NC-ND 3.0).Publication Open Access Energy and nutrient content of weight-loss diets published in high-circulation newspapers(ASOC ESPANOLA DIETISTAS NUTRICIONISTAS, 2021-09-30) GÜNEŞ, FATMA ESRA; Garipoglu, Gokcen; Aktac, Sule; Gunes, Fatma EsraIntroduction: The press is one of the most effective methods to provide the public with health education and to increase knowledge levels related to health in society. Nutritional advice and weight loss diets are also frequently featured in newspapers. However, diets in newspaper limit food groups and/or nutrients to achieve faster results. This study aimed to assess diet lists published in newspapers in terms of energy and nutrient contents and to compare levels with requirements. Material and Methods: From 1th February 2018 to 31th January 2019, nutritional and diet news included in 10 newspapers with high circulation in Turkey were investigated and diets published in these newspapers were investigated. The energy, macro, and micronutrient contents were compared with the Turkey Nutrition Guide recommendations. Results: It appeared diet lists met 55.5% of energy requirements for women and 44.5% of energy requirements for men. Carbohydrate and protein contents of diets were below recommendations, while fat contents were identified to be above-recommended levels. Dietary fiber was determined to meet 81.2% of recommendations. For micronutrients, calcium and iron contents were below recommended levels. Conclusions: It appears weight-loss diets in newspapers are insufficient in terms of energy and some nutrients. Though these diets, which are easily accessible by a large portion of society, without expert control they may cause nutrient deficiencies in the long term.Publication Open Access The Relationship Between University Students' Nutritional Status, Cardio-Metabolic Biomarkers and Physical Activity Levels(MARMARA UNIV, INST HEALTH SCIENCES, 2021-03-09) GÜNEŞ, FATMA ESRA; Icen, Hayrunisa; Gunes, Fatma EsraObjective: This study aimed to evaluate the relationship between nutritional status, cardiometabolic biomarkers and physical activity levels in university students. Methods: Firstly, fasting plasma total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C) levels were analyzed from participants' blood samples, and the homeostatic model assessment of insulin resistance (HOMA-IR) values were calculated after measuring fasting plasma glucose and insulin. Participants' weight, height, percentage of body fat, waist and hip circumference were measured and body mass index (BMI) was calculated. The International Physical Activity Questionnaire (IPAQ)and a questionnaire on socio-demographic characteristics were applied to participants. Energy and nutrient intakes were calculated from participants'24-hour dietary recall records. The statistical analysis of data was performed with SPSS version 21 software. For statistical significance, the total type-1 error level was determined as 5%. Results: Most of the participants' energy, dietary fibre, vitamins D and B1, folate, calcium and iron intakes were below recommended levels. HDL-C level was shown to be negatively correlated with total fat and saturated fatty acid intake (p<0.05). Omega-3 intakes of participants were negatively correlated with fasting plasma insulin and HOMA-IR (p<0.05).HDL-C was negatively correlated with BMI and waist-to-hip ratio, while fasting plasma insulin, triglyceride levels and HOMA-IR values were positively correlated with them (p<0.05). According to the IPAQ, it was found that 15.9% of participants had a low level of physical activity and 66.1% of them had a moderate level of physical activity. Conclusion: It is concluded that providing nutrition education and counselling services to students, improving campus facilities for physical activity are necessary for cardiometabolic health.Publication Open Access The relationship between social media use, eating attitude and body mass index among nutrition and dietetic female students: A cross-sectional study(ASOC ESPANOLA DIETISTAS NUTRICIONISTAS, 2021-04-06) KARĞIN, DİCLE; Aktac, Sule; Kargin, Dicle; Gunes, Fatma EsraIntroduction: This study aimed to investigate the relationship between media using habits, frequency and duration, and body mass index on eating attitudes. Material and Methods: The cross-sectional study was conducted with female students who received nutrition and dietetics education in Istanbul. A questionnaire consisting of a socio-demographic questionnaire, Eating Attitude Test (EAT-40), and Social Media Attitude Scale was applied to 1248 female volunteers by the face-to-face interview method. Results: It was found that 35.7% of the participants had abnormal eating attitudes and 89.6% showed a positive attitude towards social media. 93.7% of the group with abnormal eating attitudes indicated a positive attitude towards social media, 0.4% had a negative attitude and the difference was statistically significant (p=0.001). It was observed that a significant difference between EAT-40 and thought of an eating problem, having a social media membership, and spending time on social media (p<0.05). Conclusions: Social media have an effect on nutrition dietetics students on abnormal eating attitude; it did not show a significant effect on BMI.Publication Open Access Ağrı ve Beslenme(2020) GÜNEŞ, FATMA ESRA; Hanife Banu AYDIN;FATMA ESRA GÜNEŞAğrı, hemen her bireyin yaşamı boyunca belirli zamanlarda deneyimlediği, yaşam aktivitelerindeki bağımsızlık dengesini ve yaşam kalitesini olumsuz etkileyen gerçek ya da potansiyel bir doku hasarıyla ilişkili duyusal ve duygusal bir durumdur. Ağrının tedavisinde ve yönetiminde, günümüzde büyük oranda farmakolojik yöntemler kullanılsa da bütüncül ve disiplinler arası tedavi yaklaşımlarına göre uygun beslenme müdahaleleri ile hastaların genel sağlık sonuçları iyileştirilmekte, sistemik inflamatuar durumları azaltılmakta ve böylece ağrı tedavisine destek sağlanmaktadır. Besinlerin içerdikleri antioksidanlar, vazokonstriktör veya vazodilatör maddeler, beslenme durumunun metabolizmadaki inflamatuar ve oksidatif etkileri, bazı besin öğelerinin, ağrının iletim ve algılanma yollarındaki nörofizyolojik rolleri, ağrı ile beslenme ilişkisini önemli kılmaktadır. Dengesiz beslenmeyle oluşan adipozite artışı, doymuş yağ ve basit karbonhidrat oranı yüksek olan diyetler, beslenmenin vitamin, mineral ve antioksidan içeriğinin yetersiz olması sistemik inflamatuar süreçleri tetikleyerek, santral ve periferik sinirlerde ağrı duyarlılığını artırır, ağrının patolojik bir hâl almasına zemin hazırlar. Ağrılı bireylerin beslenme durumlarının düzeltilmesiyle, ağrıyı teşvik eden besin öğe/gruplarının diyetten elemine edilmesi/azaltılmasıyla ve bazı besinsel faktörlerin/takviyelerin kontrollü bir şekilde beslenmeye dâhil edilmesiyle ağrılı durumlarda iyileşme sağlanabilir, bireylerin yaşam kaliteleri ve işlevselliklerigeliştirilebilir. Beslenme durumunun, diyet modifikasyonlarının, besin öğeleri ve diğer besinsel faktörlerin ağrıyla ilişkilendirildiği çalışmalar, güncel araştırma konuları arasında önemli yer tutmaktadır. Bu çalışmada da beslenme ve diyeti, ağrıyla ilişkilendiren araştırmaların bir derlemesi sunulmaya çalışılmıştır.Publication Open Access The relationship between polyphenols and miRNAs: A novel therapeutic strategy for metabolic associated fatty liver disease(2021-05-01) EREN, FATİH; GÜNEŞ, FATMA ESRA; Bayram H. M., EREN F., Gunes F. E.Metabolic-associated fatty liver disease (MAFLD) is a public health problem that is increasingly recognized, currently affecting up to a quarter of the world\"s adult population. Although a biopsy is the current gold standard to diagnose MAFLD, there are potentially serious complications, making it inadequate. Thus far, noninvasive methods have not been able to determine the stage and the subtype of MAFLD. The development and prognosis of MAFLD are modulated by epigenetic factors, including microRNAs (miRNAs), which may be potential biomarkers for MAFLD. Polyphenols, found in many fruits and vegetables, may be useful, as they alter gene expression with epigenetic factors, such as miRNAs. This review presents an overview of the relationship between polyphenols and miRNAs in MAFLD. The literature suggests that miRNAs could be used as a diagnostic method for MAFLD, especially miRNA-122 and miRNA-34a. However, though it has been demonstrated that polyphenols may contribute to improving MAFLD, to our knowledge, no study to date has shown the relationship between polyphenols and miRNAs in MAFLD. The exact mechanisms of polyphenols on miRNAs in MAFLD remain unclear. Future studies may provide hope for diet therapy for MAFLD patients as well as the development of polyphenol-related foods or drugs that target miRNAs to treat MAFLD.Publication Metadata only Evaluation of malnutrition risk of inpatients in a research and training hospital: A cross-sectional study(ELSEVIER, 2021) İSLAMOĞLU, AYŞE HÜMEYRA; Celik, Zehra Margot; Islamoglu, Ayse Humeyra; Sabuncular, Guleren; Toprak, Hatice Selcen; Gunes, Fatma EsraBackground & aims: Malnutrition is one of the most important factors affecting the prognosis of inpatients. The aim of this study is to determine the malnutrition risk of hospitalized patients and to examine the relationship between the presence of malnutrition and other parameters. Methods: The study included 162 inpatients over the age of 25 who were staying in the hospital's internal medicine service for 7 days or more and who volunteered to participate in the study. A demographic-information questionnaire, consisting of 5 sections, a 24-h food recall record, NRS-2002, NRI and Beck Depression Inventory was given to patients during bedside interviews. After obtaining the necessary permission, the anthropometric measurements and biochemical parameter values of the patients were taken from their files. All statistical analyzes were performed by researchers with the SPSS package program. Results: Of 162 patients (48.8% female, 51.2% male), 24.7% were at risk for malnutrition according to NRS-2002 and 66.7% of the patients were not depressive, based on the Beck Depression Inventory scale. The malnutrition risk was higher (60.0%) in patients who had been hospitalized for more than 15 days (p = 0.010). The majority of those with malnutrition had no problems preventing them from eating (32.5%), were found to be not depressive (52.5%) and were in the normal range of body mass index (57.5%) (p = 0.002, p = 0.034, p = 0.001; respectively). Nutrient intake was lower in patients with a higher malnutrition risk, but the difference was insignificant (p > 0.05). Albumin levels (p = 0.028) and total protein levels (p = 0.015) were significantly lower in patients who were at risk of malnutrition. While overweight patients showed higher levels of serum albumin (p < 0.001), CRP levels were found to be lower in overweight patients (p < 0.001). Conclusions: It was found that the majority of patients with malnutrition were in the normal range for BMI. Nutritional intake and biochemical parameters should be followed closely in patients who are at risk of malnutrition. Depression can be a cause for insufficient nutrition and should be evaluated, particularly in patients whose length of hospital stay is greater than 7 days. (C) 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.Publication Metadata only The effects of dietary changes on bone markers in postmenopausal vertebral osteopenia(CHURCHILL LIVINGSTONE, 2020) İSLAMOĞLU, AYŞE HÜMEYRA; Islamoglu, A. Humeyra; Garipagaoglu, Muazzez; Bicer, H. Selcen; Kurtulus, Duygu; Ozturk, Mustafa; Gunes, F. EsraBackground & aims: Nutrition is one of the most important environmental factors affecting the formation of osteopenia. The purpose of this study was to investigate the effects of dietary changes on bone formation and bone resorption markers of postmenopausal women with vertebral osteopenia. Methods: In this study, 108 women with postmenopausal vertebral osteopenia were included. Patients were observed for a month to identify their regular nutritional status. Before intervention, blood and urine samples were taken from all patients. Then, 2-day food consumption records were taken and the patients were divided into 4 groups. Different types of diets (opposite of their regular diets) were prepared for these groups (1: control, 2: reduced-carbohydrate, 3: reduced-protein, 4: reduced-sodium) and followed for 3 months. At the end of follow-ups, blood and urine samples were taken again and changes in osteocalcin (OC) and N-terminal telopeptide (NTX) levels were examined. Results: According to biochemical analysis, there was a significant decrease (p < 0,001) in OC levels in reduced protein group and an increase (p > 0,05) in reduced carbohydrate group. When NTX levels were assessed, a significant decrease (p < 0.001) in the reduced carbohydrate group and a significant increase in the reduced protein group (p < 0.05) were found. Conclusion: Our findings show that reduced carbohydrate diet protected whereas, reduced protein diet negatively affected bone health. Osteopenic individuals were thought to be able to improve bone health and their quality of life by early dietary intervention. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.Publication Open Access Validation of a food frequency questionnaire for assessing total antioxidant status(2022-04-01) GÜNEŞ, FATMA ESRA; Oztag M., GÜNEŞ F. E.Objective: To evaluate the validity of a food frequency questionnaire (FFQ) developed as a tool for assessing antioxidant intake and to investigate whether dietary total antioxidant status predicted plasma antioxidant status. Material and methods: This research was conducted at Sagl ık Bilimleri University Faculty of Medicine Immunology. Dietary intake of total antioxidants was assessed using an FFQ (82 food items), which was adopted from Satia et al. and translated into Turkish. Total antioxidant status (TAS) in plasma was assessed using enzyme-linked immunosorbent assay (ELISA) in overnight-fasting blood. The validation of the questionnaire against plasma TAS was examined using Spearman's correlation test, BlandeAltman plots, and kappa statistics. Results: The mean age of the 45 study participants (19 women and 26 men) was 45.9 ± 11.0 years. The mean plasma TAS level was 13.8 ± 6.1 mg/L, and the mean intake of total antioxidants was 114.0 ± 134.6 mg/day. There was a positive correlation between plasma TAS and the intake of total antioxidants calculated using the FFQ (r ¼ 0.73; p < 0.001). Cronbach's alpha coefficient of the questionnaire was 0.949. Conclusion: The FFQ adapted to the Turkish population and tested here was a good predictor for dietary intake of total antioxidant status.