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GÜNEŞ, FATMA ESRA

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GÜNEŞ

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FATMA ESRA

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2021 - 20222
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Start date: 2012 × Subject: Health Sciences ×

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Now showing 1 - 2 of 2
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    PublicationOpen Access
    The relationship between polyphenols and miRNAs: A novel therapeutic strategy for metabolic associated fatty liver disease
    (2021-05-01) EREN, FATİH; GÜNEŞ, FATMA ESRA; Bayram H. M., EREN F., Gunes F. E.
    Metabolic-associated fatty liver disease (MAFLD) is a public health problem that is increasingly recognized, currently affecting up to a quarter of the world\"s adult population. Although a biopsy is the current gold standard to diagnose MAFLD, there are potentially serious complications, making it inadequate. Thus far, noninvasive methods have not been able to determine the stage and the subtype of MAFLD. The development and prognosis of MAFLD are modulated by epigenetic factors, including microRNAs (miRNAs), which may be potential biomarkers for MAFLD. Polyphenols, found in many fruits and vegetables, may be useful, as they alter gene expression with epigenetic factors, such as miRNAs. This review presents an overview of the relationship between polyphenols and miRNAs in MAFLD. The literature suggests that miRNAs could be used as a diagnostic method for MAFLD, especially miRNA-122 and miRNA-34a. However, though it has been demonstrated that polyphenols may contribute to improving MAFLD, to our knowledge, no study to date has shown the relationship between polyphenols and miRNAs in MAFLD. The exact mechanisms of polyphenols on miRNAs in MAFLD remain unclear. Future studies may provide hope for diet therapy for MAFLD patients as well as the development of polyphenol-related foods or drugs that target miRNAs to treat MAFLD.
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    PublicationOpen Access
    Validation of a food frequency questionnaire for assessing total antioxidant status
    (2022-04-01) GÜNEŞ, FATMA ESRA; Oztag M., GÜNEŞ F. E.
    Objective: To evaluate the validity of a food frequency questionnaire (FFQ) developed as a tool for assessing antioxidant intake and to investigate whether dietary total antioxidant status predicted plasma antioxidant status. Material and methods: This research was conducted at Sagl ık Bilimleri University Faculty of Medicine Immunology. Dietary intake of total antioxidants was assessed using an FFQ (82 food items), which was adopted from Satia et al. and translated into Turkish. Total antioxidant status (TAS) in plasma was assessed using enzyme-linked immunosorbent assay (ELISA) in overnight-fasting blood. The validation of the questionnaire against plasma TAS was examined using Spearman's correlation test, BlandeAltman plots, and kappa statistics. Results: The mean age of the 45 study participants (19 women and 26 men) was 45.9 ± 11.0 years. The mean plasma TAS level was 13.8 ± 6.1 mg/L, and the mean intake of total antioxidants was 114.0 ± 134.6 mg/day. There was a positive correlation between plasma TAS and the intake of total antioxidants calculated using the FFQ (r ¼ 0.73; p < 0.001). Cronbach's alpha coefficient of the questionnaire was 0.949. Conclusion: The FFQ adapted to the Turkish population and tested here was a good predictor for dietary intake of total antioxidant status.