Publication: Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity
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Date
2022-01-01
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Abstract
© 2022 Marmara University Press.In this study, new nine pyrazoline derivatives were synthesized from chalcone derivatives. The antimicrobial activity of nine pyrazoline derivatives to four standard bacterial strains (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis) and four standard yeast strains (Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis) was investigated by the microdilution method for in accordance with the Clinical and Laboratory Standards Institute (CLSI) standard, and the Minimal Inhibitory Concentration (MIC) values of these derivatives were determined. Among these derivatives; compounds 7 and 8 against bacterial strains and compounds 2 and 3 against yeast strains exhibited good antimicrobial activity.
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Temel Eczacılık Bilimleri, Eczacılık, Yaşam Bilimleri, Sağlık Bilimleri, Temel Bilimler, Basic Pharmaceutics Sciences, Pharmacology and Therapeutics, Life Sciences, Health Sciences, Natural Sciences, Yaşam Bilimleri (LIFE), Farmakoloji ve Toksikoloji, FARMAKOLOJİ VE ECZACILIK, Life Sciences (LIFE), PHARMACOLOGY & TOXICOLOGY, PHARMACOLOGY & PHARMACY, Genel Farmakoloji, Toksikoloji ve Eczacılık, Farmakoloji (tıbbi), General Pharmacology, Toxicology and Pharmaceutics, Pharmacology (medical), bacteria, MIC, Pyrazoline, yeast, Pyrazoline, bacteria, yeast, MIC
Citation
TOK F., Doğan M. O. , GÜRBÜZ B., Koçyiğit-Kaymakçioğlu B., "Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity", Journal of Research in Pharmacy, cilt.26, sa.5, ss.1453-1460, 2022