Publication:
Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats

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dc.contributor.authorKARĞIN, DİCLE
dc.contributor.authorYAVUZ, AYŞE NUR
dc.contributor.authorÇAM, MUHAMMET EMİN
dc.contributor.authorAKTAÇ, ŞULE
dc.contributor.authorsKarğın D., Aktaç Ş., Yavuz A. N., Çam M. E.
dc.date.accessioned2023-02-07T07:56:13Z
dc.date.available2023-02-07T07:56:13Z
dc.date.issued2023-02-01
dc.description.abstractCornelian cherry (Cornus mas L.) has been used for centuries as a traditional herbal medicine in Europe and Asia. In this study, we aimed to describe the effect of Cornus mas L. (C. mas) on the activity of the antioxidant enzymes and a detoxification agent in rats fed a high-fat diet. Forty-eight adult Sprague Dawley rats were randomly assigned to six groups of eight animals each: Standard diet (Control), High Fat Diet (HFD), HFD + C. mas (200 mg/kg/day; 8 weeks), HFD + Atorvastatin (20 mg/kg/day; 8 weeks), HFD post-treated with C. mas (200 mg/kg/day; 4 weeks), HFD posttreated with Atorvastatin (20 mg/kg/day; 4 weeks). The activity of the antioxidant enzymes, Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), detoxification agent glutathione (GSH), and oxidative stress parameter thiobarbituric acid reactive substances (TBARS) were measured in the liver tissues. GPx, SOD, and CAT enzyme levels were decreased in HFD groups compared to the control (p < 0.05). However, Cornus mas L. promoted antioxidant activity by increasing GPx, SOD, and CAT enzymes and It also reduced oxidative stress (as an increase in GSH) both in the HFD + C. mas group and the HFD post-treated C. mas group compared to the HFD group (p < 0.05). Our study showed that feeding a high-fat diet increases oxidative stress. Cornus mas L treatment improves antioxidant enzyme activity and oxidative stress parameters in the liver tissues of rats.
dc.identifier.citationKarğın D., Aktaç Ş., Yavuz A. N., Çam M. E., "Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats", JOURNAL OF RESEARCH IN PHARMACY, cilt.27, sa.1, ss.432-440, 2023
dc.identifier.doi10.29228/jrp.325
dc.identifier.endpage440
dc.identifier.issn2630-6344
dc.identifier.issue1
dc.identifier.startpage432
dc.identifier.urihttps://jrespharm.com/uploads/pdf/pdf_MPJ_1204.pdf
dc.identifier.urihttps://hdl.handle.net/11424/286019
dc.identifier.volume27
dc.language.isoeng
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBeslenme ve Dietetik
dc.subjectSağlık Bilimleri
dc.subjectNutrition and Dietetics
dc.subjectHealth Sciences
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectKlinik Tıp (MED)
dc.subjectTarım Bilimleri
dc.subjectBESLENME VE DİYETETİK
dc.subjectAgriculture & Environment Sciences (AGE)
dc.subjectClinical Medicine (MED)
dc.subjectAGRICULTURAL SCIENCES
dc.subjectNUTRITION & DIETETICS
dc.subjectBeslenme ve Diyetetik
dc.subjectCornus mas L.
dc.subjectliver
dc.subjectantioxidant
dc.subjectglutathione
dc.subjecthigh-fat-diet
dc.titleEffects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats
dc.typearticle
dspace.entity.typePublication
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