Publication:
Nesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure

Simple item page
dc.contributor.authorARABACI TAMER, SEVİL
dc.contributor.authorKOYUNCUOĞLU, TÜRKAN
dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorYÜKSEL, MERAL
dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsArabacı Tamer S., Koyuncuoğlu T., Karagöz Köroğlu A., AKAKIN D., YÜKSEL M., YEGEN B.
dc.date.accessioned2023-03-02T07:45:02Z
dc.date.available2023-03-02T07:45:02Z
dc.date.issued2022-04-01
dc.description.abstract© 2022Aims: We aimed to investigate putative neuroprotective effects of nesfatin-1 on oxidative brain injury and memory dysfunction induced by a single epileptic seizure and to compare these effects with those of antiepileptic phenytoin. Main methods: Wistar albino rats were randomly divided into a control group and pentylenetetrazole (PTZ)-seizure groups pretreated intraperitoneally (ip) with saline or nesfatin-1 (NES-1; 0.3, 1 or 3 μg/kg/day) or phenytoin (PHE; 40 mg/kg/day) or PHE + NES-1 (0.3 μg/kg/day) at 30 min before the single-dose PTZ injection (45 mg/kg; ip). All treatments were repeated at the 24th and 48th h of the provoked epileptic seizure. Passive-avoidance test was performed to assess memory function. The rats were decapitated at the 72nd hour of seizures and brain tissues were analyzed for histopathological changes and for measuring levels of malondialdehyde, glutathione, myeloperoxidase activity and reactive oxygen/nitrogen species. Key findings: In parallel to the effects of phenytoin, NES-1 reduced seizure score, elevated antioxidant glutathione content, depressed generation of nitric oxide and protected against seizure-induced neuronal damage. Additionally, increased malondialdehyde levels and elevated glial fibrillary acidic protein immunoreactivity in the cortex and hippocampus were decreased and memory dysfunction was improved by NES-1. However, NES-1 had no impact on myeloperoxidase activity or production of reactive oxygen species in the brain. Significance: The findings of the present study demonstrate that nesfatin-1 treatment provides neuroprotection against seizure-induced oxidative damage and memory dysfunction by inhibiting reactive nitrogen species and upregulating antioxidant capacity, indicating its potential in alleviating memory deficits and increasing the effectiveness of conventional anti-convulsant therapies.
dc.identifier.citationArabacı Tamer S., Koyuncuoğlu T., Karagöz Köroğlu A., AKAKIN D., YÜKSEL M., YEGEN B., "Nesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure", Life Sciences, cilt.294, 2022
dc.identifier.doi10.1016/j.lfs.2022.120376
dc.identifier.issn0024-3205
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85124233306&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/287071
dc.identifier.volume294
dc.language.isoeng
dc.relation.ispartofLife Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectHealth Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectLife Sciences (LIFE)
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectNesfatin-1
dc.subjectSeizure
dc.subjectOxidative injury
dc.subjectMemory dysfunction
dc.subjectApoptosis
dc.subjectNITRIC-OXIDE
dc.subjectISCHEMIA-REPERFUSION
dc.subjectHIPPOCAMPAL-NEURONS
dc.subjectSATIETY MOLECULE
dc.subjectKAINIC ACID
dc.subjectSTRESS
dc.subjectINJURY
dc.subjectANTIOXIDANT
dc.subjectAPOPTOSIS
dc.subjectPROTECTS
dc.titleNesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure
dc.typearticle
dspace.entity.typePublication
local.avesis.idd22d1408-05d6-4dd2-bae2-fbba6827e405
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication6cf6597c-7986-4621-b28a-9e4d7bc35803
relation.isAuthorOfPublicatione146f762-5a31-46c5-a898-7594b85c6da6
relation.isAuthorOfPublicationc97c0ebf-ffce-4b27-a933-941a53767b0d
relation.isAuthorOfPublication8b13d479-2f3b-4180-bc71-7ad5a5625f1b
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscovery6cf6597c-7986-4621-b28a-9e4d7bc35803

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
3.pdf
Size:
24.02 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs