Publication: Temperature dependence studies and microscopic protonation constants of L-alanine and β-alanine in acetonitrile – water mixtures
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Date
2022-07-01
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Abstract
L-alanine and β-alanine are important biological molecules and have zwitterion structure. In this study, Lalanine and β-alanine’s microscopic protonation constants and thermodynamic parameters (enthalpy, entropy, and free
energy changes) for the proton–ligand systems of L-alanine methyl ester, β-alanine and β-alanine methyl ester have been
determined at 5; 20; 35 °C, in ACN-water (25% ACN and 50% ACN (v/v)) mixtures at constant ionic strength of 0.1000
mol L–1 NaClO4 by potentiometric method. The results shown that, L-alanine and β-alanine’s microscopic protonation
constants generally tend to decrease with temperature rise and their protonation reactions in ACN-water mixtures
generally favor enthalpy-driven.
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Keywords
L-alanine, β-alanine, microscopic protonation constants, thermodynamics parameters
Citation
ERENSOY H., BİLĞİÇ ALKAYA D., AYAZ SEYHAN S., "Temperature dependence studies and microscopic protonation constants of L-alanine and β-alanine in acetonitrile – water mixtures", Ovidius University Annals of Chemistry, cilt.33, sa.2, ss.99-103, 2022