Publication: The role of free vitamin D and vitamin D binding protein in SARS‐Cov‐2 infection in children
Files
Date
2023-10-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Many studies have discussed the effects of serum vitamin D deficiency
in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients. This
study aimed to investigate the relationship between SARS-CoV-2 infection severity
and free vitamin D (FVD) and bioavailable vitamin D (BAVD) levels in children.
Methods: A prospective case–control study design was used. Participants were
divided into three groups based on the World Health Organization COVID-19
Clinical Progression Scale. Serum 25-hydroxyvitamin D (ng/mL), albumin (g/L),
and vitamin D binding protein (ng/mL) levels were evaluated to investigate the
relationship between disease severity and FVD and BAVD levels.
Results: In total, 82 participants were included in the study. Of those, 24.4% were
uninfected (n=20), 50% had a mild case of SARS-CoV-2 (n=41), and 25.6% had
a moderate case (n=21). There was a statistically significant difference in FVD
and BAVD levels between the groups (p=0.026). Median FVD (p=0.007, Cohen's
d=0.84) and BAVD (p=0.007, Cohen's d=0.86) levels were significantly higher in
the mild group compared to the moderate group. FVD and BAVD metabolites
were moderately positively correlated with lymphocyte counts (FVD: r=0.437,
p<0.001; BAVD: r=0.439, p<0.001).
Conclusions: This is the first study to demonstrate a relationship between SARSCoV-2 symptom severity and FVD and BAVD levels. The relationship between
FVD and BAVD levels and lymphocyte counts could play an important role in
symptom severity and should be evaluated in further studies.
Description
Keywords
Sağlık Bilimleri, Health Sciences, Klinik Tıp (MED), Clinical Medicine (MED), child, SARS-COV-2, vitamin D, vitamin D binding protein, vitamin D deficiency
Citation
Us M. C., "The role of free vitamin D and vitamin D binding protein in SARS‐Cov‐2 infection in children", PEDIATRICS INTERNATIONAL, cilt.65, sa.1, ss.1-9, 2023