Person: EMRE, GİZEM
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EMRE
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GİZEM
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Publication Metadata only Medicinal and wild food plants of Marmara Island (Balikesir - Turkey)(POLSKIE TOWARZYSTWO BOTANICZNE, 2016) EMRE, GİZEM; Bulut, GizemMedicinal and wild food plants have always played an important role in people's lives especially in rural areas. Similar situation can be said for islands due to the reason of them being isolated from mainland. This paper reports an ethnobotanical investigations performed in 2009 and 2014 to determine medicinal and wild food plants of Marmara Island. A total of 30 individuals were interviewed (19 men, 11 women). Totally, 22 plants are recorded as used as traditional folk medicine for the region, and nine of these are also used as a source of wild food. Furthermore, 18 taxa are wild sources of nutrition for the area. The plants most commonly used in the region as medicinal remedies were Salvia fruticosa, Hypericum perforatum, Ficus carica, and Mentha spicata. Plants are mostly used for the treatment of abdominal pain, the common cold, and haemorrhoids. The species most commonly used for food are: Salvia fruticosa, Arbutus unedo, Rhus coriaria, and Rubus sanctus. This ethnobotanical study conducted in this island will enable the traditional use of wild plants both as food sources and herbal remedies to be passed on to future generations.Publication Metadata only In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz-An endemic folk medicinal plant(ELSEVIER SCI LTD, 2018) EMRE, GİZEM; Zengin, Gokhan; Bulut, Gizem; Mollica, Adriano; Picot-Allain, Carene Marie Nancy; Mahomoodally, Mohamad FawziCentaurea saligna (K.Koch) Wagenitz is an endemic plant used in Turkish folk medicine as antibacterial, tonic, astringent, choleretic, anti-rheumatic, diuretic, and antipyretic. This study attempts for the first time to assess the possible enzyme inhibitory potential, antioxidant activity, and determine the phytochemical profile of the ethyl acetate, methanol, and water extracts of C. saligna. The water extract had the highest phenolic content (30.18 mg GAE/g extract) and the most potent oxidant scavenging activity ((120.53, 111.90, 68.43, and 157.88 mg TEN extract, for CUPRAC [cupric reducing antioxidant capacity], FRAP [ferric reducing antioxidant power], DPPH [2,2-dipheny1-1-picrylhydrazyl], and ABTS [2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid] assays respectively)). The water extract (4.16 mg KAE/g extract) also inhibited tyrosinase and contained high level of catechin (214 mu g/g extract). Ethyl acetate extract showed potent inhibitory capacity against cholinesterases (2.22 and 2.21 mg GALAE/g extract for acetyl and butyryl cholinesterase, respectively) and alpha-glucosidase (23.80 mmol ACAE/g extract). High concentration of apigenin (2472 mu/g extract) was identified in the ethyl acetate extract. In silico studies showed that apigenin binds to the enzymatic pocket of alpha-glucosidase and is stabilised by a network of hydrogen bonds and pi-pi stacking. Data collected in the present study advocates the need for further investigation geared towards validation of C. saligna for the management of complications related to the target enzymes, such as diabetes type II, Alzheimer's disease, and epidermal hyperpigmentation. (C) 2018 Elsevier Ltd. All rights reserved.Publication Open Access A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques(ELSEVIER SCI LTD, 2020-04) EMRE, GİZEM; Zengin, Gokhan; Cvetanovic, Aleksandra; Gasic, Uros; Tesic, Zivoslav; Stupar, Alena; Bulut, Gizem; Sinan, Kouadio Ibrahime; Uysal, Sengul; Picot-Allain, Marie Carene Nancy; Mahomoodally, Mohamad FawziWe endeavoured to probe into and compare the possible effect(s) of different extraction techniques (accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), ultrasonication-assisted extraction (UAE), maceration, and Soxhlet extraction (SE)) on the bioactivity (antioxidant and enzyme inhibitory activities) of the aerial parts of Helichrysum stoechas subsp. barrelieri (Ten.) Nyman. Total phenolic and flavonoid contents of the extracts obtained by different extraction methods followed the order of ASE > MAE > UAE > maceration > SE. Extract obtained by ASE was the most potent radical scavenger (219.92 and 313.12 mg Trolox equivalent [FE]/g, against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing agent (927.39 and 662.87 mg TE/g, for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). Helichrysum stoechas extract obtained by UAE (18.67 mg ethylenediaminetetraacetic equivalent [EDTAE]/g) was the most active metal chelator and inhibitor of acetylcholinesterase (4.23 mg galantamine equivalent [GALAE]/g) and butyrylcholinesterase (6.05 mg GALAE/g) cholinesterase. Extract from maceration (183.32 mg kojic acid equivalent [KAE]/g) was most active against tyrosinase while ASE extract (1.66 mmol acarbose equivalent [ACAE]/g) effectively inhibited alpha-glucosidase. In conclusion, data amassed herein tend to advocate for the use of non-conventional extraction techniques, namely ASE and UAE, for the extraction of bioactive secondary metabolites from H. stoechas aerial parts.Publication Metadata only Chemical composition and bio-functional perspectives of Erica arborea L. extracts obtained by different extraction techniques: Innovative insights(ELSEVIER, 2019) DOĞAN, AHMET; Zengin, Gokhan; Cvetanovic, Aleksandra; Gasic, Uros; Stupar, Alena; Bulut, Gizem; Senkardes, Ismail; Dogan, Ahmet; Seebaluck-Sandoram, Roumita; Rengasamy, Kannan R. R.; Sinan, Kouadio Ibrahime; Mahomoodally, Mohamad FawziErica arborea L., also known as Estrella Gold, is traditionally used for several purposes. In this research, five different extraction techniques: accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), maceration (MAC), soxhlet (SOE) and ultrasound-assisted extraction (UAE) were used to compare the total phenolic, flavonoids, total antioxidant activity and enzymatic activities of E. arborea extracts obtained different extraction techniques. The total phenolic and flavonoid contents were in the order of ASE > MAE > SOE > MAC > UAE. All extracts showed antioxidant, anticholinesterase, anti-tyrosinase and anti-diabetic activities. A highly sensitive method using ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap-MS) has been used for the qualitative analysis of obtained extracts. Seventy-two polyphenolic compounds were identified in all extracts. However, 20 components were quantified among the extracts. ASE was found to be a better extraction technique as compared to the other extraction techniques. E. arborea can be exploited in the discovery of bioactive natural products for the treatment of Alzheimer's disease, diabetes and pigmentation problems.Publication Metadata only THERAPEUTIC POTENTIAL OF MYRTUS COMMUNIS SUBSP COMMUNIS EXTRACT AGAINST ACETIC ACID-INDUCED COLONIC INFLAMMATION IN RATS(WILEY, 2017) ŞEN, ALİ; Sen, Ali; Yuksel, Meral; Bulut, Gizem; Bitis, Leyla; Ercan, Feriha; Ozyilmaz-Yay, Nagehan; Akbulut, Ozben; Cobanoglu, Hamit; Ozkan, Sevil; Sener, GokselThe aim of this study was to evaluate the effect of ethanol extract from leaves of Myrtus communis subsp. communis (MC) on acetic acid (AA)-induced ulcerative colitis in rats. On the fourth day of colitis induction, all rats were decapitated. Colitis was assessed by macroscopic and microscopic scores and by measuring malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity, luminol, lucigenin, nitric oxid and peroxynitrite chemiluminescence (CL). Colitis caused significant increases in the colonic MDA levels, MPO activity, CL values, macroscopic and microscopic damage scores along with significant decrease in tissue GSH level. However, treatment with MC extract reversed all these biochemical indices, as well as histopathological alterations induced by AA with the protective effects being similar to that of sulphasalazine treatment. The study showed that MC extract could alleviate colitis in rats and can be considered an alternative therapeutic approach for management of inflammatory bowel diseases (IBD).Publication Metadata only Gümüşi ıhlamur (Tilia tomentosa Moench.) çiçek durumu standardizasyonunda kullanılan farmakognozik yöntemler(2020-02-01) EMRE, GİZEM; GÜZELMERİÇ E., Yüksel P. I., BULUT G., YEŞİLADA E.Ihlamur çiçek durumu, Tilia (ıhlamur) cinsinin çiçekleri ve braktesinden oluşur. Ihlamur, sahip olduğu farmakolojik etkilerinden (örn. sedatif, spazmolitik, anti-enflamatuvar, ekspektoran) dolayı yüzyıllardır halk ilacı olarak kullanılmaktadır. Sağlığa yararlı etkileri içerdiği flavonoit (tilirozit, astragalin, izokersitrin, hiperozit vb.), müsilaj, uçucu yağ (1,8-sineol, timol, karvakrol, benzaldehit vb.), kafeik asit, klorojenik asit gibi maddelerden ileri gelmektedir. Tıbbi olarak T. cordata Miller (küçük yapraklı ıhlamur) ve T. platyphyllos Scop. (büyük yapraklı ıhlamur) türleri çeşitli farmakopelerde (örn. Avrupa Farmakopesi) yer almaktadır. Ancak, bu türler Türkiye’de ya doğal olarak yetişmez (T. cordata) ya da nadiren (T. platyphyllos) bulunur. Buna karşın, ülkemizde Tilia rubra DC. (Kafkas ıhlamuru) Karadeniz Bölgesi’nde, Tilia tomentosa Moench. (sin. Tilia argentea Desf.) ise Marmara Bölgesi’nde bolca yetişir. T. tomentosa yapraklarının alt yüzeyinde beyazımsı yıldız tüyler taşıması sebebiyle gümüşi ıhlamur olarak adlandırılır. Tıbbi türlerin az yetişmesi nedeniyle, Türkiye’de halk ilacı olarak bolca yetişen T. rubra ve T. tomentosa türleri sıklıkla kullanılır. Ancak, bu iki tür de Avrupa Farmakopesi’nde yer almamaktadır. Bu çalışmada, T. cordata, T. platyphyllos ve T. cordata, T. platyphyllos ve T. vulgaris karışımı (tıbbi türler) ile Marmara Bölgesi’nin farklı yerlerinden toplanan T. tomentosa örnekleri kıyaslanarak Türk Farmakopesi’nde yer alması önerilen ‘Gümüşi ıhlamur çiçek durumu’ monografı hazırlanması hedeflenmiştir.Publication Open Access The preliminary ethnobotanical study of medicinal plants in Usak (Turkey)(MARMARA UNIV, FAC PHARMACY, 2017-04-01) EMRE, GİZEM; Bulut, Gizem; Bozkurt, M. Zahid; Tuzlaci, ErtanThis study was made to reveal the plants used as traditional folk medicine in Usak in 2013. The specimens of the plants used as folk remedies have been collected and the information about the local names, the part(s) used, the ailments treated, the therapeutic effect, the preparation, the methods of administration, and the duration of treatment were recorded. The plant specimens are kept in the Herbarium of the Faculty of Pharmacy, Marmara University. As a result of identification of the plant specimens, 38 species, used as a traditional folk medicine in Usak, have been determined. According to the majority of the plants which have similar usages, the plants were mostly used for gastrointestinal system diseases, respiratory system diseases and urinary system diseases.Publication Metadata only HPLC-MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata(ELSEVIER SCIENCE BV, 2018) DOĞAN, AHMET; Zengin, Gokhan; Diuzheva, Alina; Jeko, Jozsef; Cziaky, Zoltan; Bulut, Gizem; Dogan, Ahmet; Haznedaroglu, Mehmet Zeki; Rengasamy, Kannan R. R.; Lobine, Devina; Bahadori, Mir Babak; Mahomoodally, Mohamad FawziArnelanchierparviflora var. dentata is an endemic medicinal plant traditionally consumed to treat stomach pain, cardiovascular diseases, and urinary tract infections in Turkey's folk medicine. Although Amelanchier genus is an excellent source of phytochemicals with a panoply of biological activities, no report has been made available on Amelanchier parviflora var. dentata. Thus, the metabolic profiles of methanol, ethyl acetate, and water extracts were obtained using HPLC-MS/MS. Besides, the pharmacological properties such as antioxidant activity and enzyme inhibition effects against acetyl/butyrylcholinesterase, tyrosinase, alpha-amylase, and alpha-glucosidase were evaluated. In total, 62, 38, and 16 metabolites were Identified from the methanolic, water, and ethyl acetate extracts, respectively. The identified metabolites belong to anthocyanins, phenolic acids, and flavonoids. The tested extracts exhibited different enzyme inhibitory activity against cholinesterases (acetylcholinesterase: 0.52-2.47 mg GEs/g extract and butyrylcholinesterase: 0.47-3.59 mg GEs/g extract), tyrosinase (19,0-145.54 mg KAEs/g extract), alpha-amylase (0.23-1.10 mmol ACEs/g extract), and alpha-glucosidase (8.89-9.92 mmol ACEs/ g extract). Evidence from the present study supports the necessity for more research in an endeavor to discover biologically active secondary metabolites from A. parviflora to manage specific ailments.Publication Metadata only The folk-medicinal plants of Kadisehri (Yozgat - Turkey)(POLSKIE TOWARZYSTWO BOTANICZNE, 2015) EMRE, GİZEM; Han, Muhammed Ihsan; Bulut, GizemThis paper contains significant ethnobotanical information on folk-medicinal plants and their ethnopharmacological uses in Kadisehri. The aim of the study was mainly to collect and identify the plants used therapeutically by the local people, and to make available information about traditional herbal medicine. It was undertaken during the period 2011-2012 and is based on plants collected during field work. Fifty-six plants used in folk-medicine and belonging to 34 families were identified in this study. Of these, 48 species were wild, and 8 species were cultivated plants. The most common families were Rosaceae (12.5%), Lamiaceae (8.9%) and Asteraceae (7.1%); and the most common preparations were decoctions (36.7%). In addition, a cultural importance index (CI) and use report (UR) were calculated for each species. Based on the CI, the most important plants were Cydonia oblonga (0.77), Ecballium elaterium (0.66), Urtica urens (0.66), Vitis vinifera (0.66), Plantago lanceolata (0.65), Plantago major subsp. major (0.65) and Rosa canina (0.62). We found three species of plant (Astragalus noaeanus, Populus xcanescens and Salvia cyanescens) which had never before been reported to have medicinal properties.Publication Open Access Antioxidant and anti-inflammatory activities of Phlomis pungens and Coridothymus capitatus(MARMARA UNIV, FAC PHARMACY, 2018-01-12) YAVUZ, AYŞE NUR; Taskin, Turgut; Cam, Muhammet Emin; Bulut, Gizem; Hazar-Yavuz, Ayse Nur; Kabasakal, Levent; Bitis, LeylaThe purpose of this study was to comparatively reveal for the first time the antioxidant, anti-inflammatory effects of Phlomis pungens and Coridothymus capitatus methanol extracts obtained by using maceration extraction method. According to the results of anti-inflammatory activity, P. pungens methanolic extract demonstrated a more prominent and intensive antiinflammatory effect with 24.7% of inhibitive capacity in the altered edema size after the first hour of carrageenan injection compared to C. capitatus methanolic extract. P. pungens methanolic extract inhibitory effect increased during three hours and reached maximum by 41.9%. According to the results obtained from antioxidant activity experiments, methanol extract of C. capitatus exhibited stronger free radical scavenging (DPPH), cupric reducing (CUPRAC), ferric reducing/antioxidant power (FRAP) and ABTS radical cation scavenging activity than P. pungens extract. In additon, C. capitatus extract had higher ABTS radical cation scavenging and ferric reducing/antioxidant power activity than ascorbic acid, BHT and BHA, respectively. Therefore, this extract can be used in both medicine and food industry as a natural antioxidant source.
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