Person: ÖZTÜRK ÖZENER, HAFİZE
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ÖZTÜRK ÖZENER
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HAFİZE
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Publication Open Access Klorheksidinin insan dişeti fibroblastları üzerindeki hücre canlılığı ve sitotoksisite etkinliğinin in vitro koşullarda değerlendirilmesi(2023-04-01) YILMAZ GÖLER, AYŞE MİNE; ÖZTÜRK ÖZENER, HAFİZE; Bayraktar G., YILMAZ GÖLER A. M., ÖZTÜRK H.Amaç: Bu in vitro çalışmada, % 0,2’lik klorheksidin (CHX) solüsyonunun, insan dişeti fibroblast (HGF) hücre canlılığı ve sitotoksisitesi üzerindeki etkilerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Bu çalışma 30 saniye ve 2 dakikalık zaman aralıklarında, nötr pH değerindeki % 0,2’lik CHX solüsyonu ve hücre olarak ATCC’den ticari olarak temin edilen HGF-1 (CRL2014) hücre hatları kullanılarak gerçekleştirildi. CHX’in HGF üzerindeki hücre canlılığı etkileri 3-(4,5-dimetiltiazol-2-il)-2,5- difeniltetrazolyum bromür (MTT) testi ile ve sitotoksik etkileri laktat dehidrogenaz (LDH) testi ile değerlendirildi. Sonuçlar ortalama ve standart sapma değerleri kullanılarak two way ANOVA testiyle istatistiksel olarak analiz edildi (p<0,05). Bulgular: MTT testi sonuçlarına göre, % 0,2 CHX solüsyonunun zamanla hücre canlılığını azalttığı görüldü (p<0,0001). LDH testi sonuçlarına göre ise % 0,2 CHX’in sitotoksik etkinliğinin kontrol grubuna kıyasla arttığı (p<0,0001) ancak zaman içinde istatistiksel olarak anlamlı bir fark göstermediği (p>0,05) gözlendi. Sonuç: Bu in vitro çalışmanın sınırları dahilinde, % 0,2 CHX solüsyonu, 30 sn ve 2 dk’lık kısa maruz kalma sürelerinde, HGF hücre canlılığını azalttı ve HGF üzerinde sitotoksik etki gösterdi.Publication Metadata only Yaşlı Bireylerde Cerrahi Olmayan Periodontal Tedavi Yaklaşımı(Türkiye Klinikleri Yayınevi, 2022-12-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; Öztürk Özener H., Ağralı Ö. B., Doğan B.Publication Open Access Periodontal treatment approach for dihydropyridine induced gingival overgrowth with or without drug substitution(2022-06-01) ÖZTÜRK ÖZENER, HAFİZE; KURU, LEYLA; Eroğlu O., YETİŞ E., ÖZTÜRK H., KURU L.Objectives: The aim of this study is to evaluate clinical effectiveness of nonsurgical periodontal treatment (NSPT) in patients with drug induced gingival overgrowth (DIGO) with or without drug substitution in comparison with patients presenting inflammatory gingival overgrowth (GO). Material and Methods: A total of 17 patients with generalized GO were included in this clinical trial. Based on the medical physicians consultation, DIGO patients who continued using dihydropyridine were allocated to the Group 1 (n=6), whereas patients whose drug substitution was carried out were allocated to the Group 2 (n=5). Group 3 (n=6) subjects had inflammatory GO. All study groups received NSPT for 4 sessions. At baseline and 6 weeks after NSPT, plaque index, gingival index, bleeding on probing (BOP), probing depth (PD) and, plaster model and photographic GO scores were measured. Results: NSPT resulted in significant decreases in periodontal clinical parameters in all groups (p<0.05). Intergroup comparisons of baseline measurements revealed no statistically significant differences (p>0.05) except PD value which was higher in the Group 1 compared to the Group 2 (p<0.05). Comparisons of post-NSPT data among groups exhibited statistically significant difference only between Groups 1 and 2 in the model and photographic GO scores (p<0.05). Conclusions: After the 6-week evaluation period, NSPT was found to be an effective method in reducing the severity of inflammation and size of overgrown gingival tissues in patients with DIGO and inflamatory GO. Substitution of drug causing GO provided further contribution to NSPT regarding the size of overgrown gingiva in the patients with DIGO.Publication Metadata only Yaşlı bireylerde cerrahi olmayan periodontal tedavi yaklaşımı(Türkiye Klinikleri, 2022-01-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; ÖZTÜRK H., AĞRALI Ö. B., DOĞAN B.Publication Open Access Assessment of reliability of three indices measuring gingival overgrowth procjena pouzdanosti triju indeksa za mjerenje hiperplazije gingive(2023-06-01) ÖZTÜRK ÖZENER, HAFİZE; KURU, LEYLA; Alkateb A. S., ÖZTÜRK ÖZENER H., KURU L.Objectives: Numerous indices have been used to grade the severity of gingival overgrowth which led to suspicion regarding the results concerning its prevalence and pathogenicity. The aim of this study was to assess the concordance of three different gingival overgrowth indices, which were used wide-ly in previous studies, and check their reliability and reproducibility. Material and Methods: A total of 30 full-mouth plaster casts and 90 intra-oral photographs collected from 30 patients diagnosed with gingival overgrowth were included in our study. Three trained examiners performed measurements twice on plaster casts using gingival hyperplasia index (A index) and hyperplastic index (B index). In-traoral photographs were assessed also twice using (C index). Results: Concordance of intra-exam-iner and inter-examiner reliability of the recorded measurements was carried out for each index using weighted kappa (K), with a confidence interval of 95%. The A index revealed intra-examiner total kappa values between 0.724-0.876 for horizontal measurement and 0.512-0.823 for vertical mea-surement, and inter-examiner total kappa values between 0.255-0.626 horizontally and 0.235-0.279 vertically. The B index presented intra-examiner total kappa values between 0.587-0.868 horizontally and 0.653-0.855 vertically; and inter-examiner total kappa values between 0.393-0.595 and 0.372-0.635 for horizontal and vertical measurements, respectively. The C index achieved the highest intra-examiner concordance with total kappa values between 0.758-0.855 and inter-examiner total kappa values between 0.716-0.804. Conclusions: The C index evaluated through intraoral photographs is considered the most reliable and applicable method to be utilized. The C index is suggested to be used in large scale populations with its definite detailed criteria.Publication Metadata only Radiographic Evaluation of the Effect of Vitamin D3 Supplementation on Regeneration of Calvarial Bone Defects in Rats(2023-09-01) AĞRALI, ÖMER BİRKAN; YILDIRIM, HATİCE SELİN; KURU, LEYLA; ÖZTÜRK ÖZENER, HAFİZE; HANCILAR G. N., AĞRALI Ö. B., GÜNGÖRMEK H. S., DEMİRCİ DELİPINAR S., KURU L., ÖZTÜRK ÖZENER H.Publication Metadata only Evaluation of Patient's Perceptions, Healing, and Reattachment After Conventional and Diode Laser Frenectomy: A Three-Arm Randomized Clinical Trial(MARY ANN LIEBERT, INC, 2020) ÖZTÜRK ÖZENER, HAFİZE; Sezgin, Gamze; Ozener, Hafize Ozturk; Meseli, Suleyman Emre; Kuru, LeylaObjective:The aim of this study is to compare the conventional and diode laser techniques in terms of patient's perceptions, epithelization, reattachment, and periodontal clinical parameters in the treatment of abnormal papillary frenum. Materials and methods:Forty-eight patients with abnormal papillary frenum were enrolled in the study. Patients were randomly assigned into three groups; conventional frenectomy operation (C group), diode laser-assisted frenectomy (L group), and diode laser-assisted frenectomy with conventional horizontal incision on the periosteum (L + P group). Post-operative pain, discomfort in speaking, and chewing scores were assessed with visual analogue scale (VAS) at post-operative 3rd hour and on days 1, 7, 14, 21, and 45. Epithelialization process of the wound surface was evaluated by hydrogen peroxide solution applied to the wound on days 7, 14, 21, and 45 following operations. The distance between the frenum attachment point and mucogingival junction (FMGJ) was recorded at baseline, post-operative 45th day, and 6th month to assess the reattachment of the frenum. Plaque index, gingival index, bleeding on probing, and probing depth were recorded at baseline and post-operative 7th, 14th, 21(st), and 45th days. Results:On the 1st and 7th day after operation, VAS pain score in the C group was significantly higher than in the L and L + P groups (p < 0.017). Difficulty in speaking and chewing scores were significantly lower in the L and L + P groups compared to the C group at post-operative 3rd hour and 7th day (p < 0.017). The FMGJ and epithelization period demonstrated no difference among the groups at any time point (p > 0.05). Conclusions:Our results suggest that diode laser provides better post-operative patient's perceptions than the conventional technique in frenectomy operation. In addition, both conventional and laser-assisted frenectomy surgeries prevent the frenum reattachment regardless of periosteal horizontal incision.Publication Metadata only Rat kalvaryal defektlerinde D3 vitamininin yönlendirilmiş kemik rejenerasyonu üzerine etkisinin değerlendirilmesi(2022-11-06) AĞRALI, ÖMER BİRKAN; YILDIRIM, HATİCE SELİN; KURU, LEYLA; ÖZTÜRK ÖZENER, HAFİZE; HANCILAR G. N., AĞRALI Ö. B., GÜNGÖRMEK H. S., DEMİRCİ DELİPINAR S., KURU L., ÖZTÜRK ÖZENER H.Amaç: Bu çalışmada oral yolla verilen D3 vitamininin ratlarda yönlendirilmiş kemik rejenerasyonuna etkisinin histolojik olarak değerlendirilmesi amaçlandı. Gereç-Yöntem: Çalışma 12 adet erişkin erkek SpragueDawley cinsi rat üzerinde gerçekleştirildi. Tüm ratların kalvaryal kemiklerinde 5 mm çapında oluşturulan defektlere sığır kaynaklı kemik grefti (BioOss®) ile birlikte kolajen esaslı rezorbe olabilen membran (BioGide®) uygulandı. Cerrahi sonrası ratlar rastgele iki gruba ayrıldı; birinci gruba (Kontrol Grubu) distile su, ikinci gruba (Test Grubu) ise 2 µg /kg D3 vitamini günde 1 kez olmak üzere gavajla 8 hafta boyunca verildi. 8 haftanın sonunda ratlar sakrifiye edildi. Hematoksilen-Eozin ile boyanan örnekler histolojik olarak incelendi. ImageJ yazılım programı kullanılarak yeni kemik, rezidüel greft ve fibröz doku alanları hesaplandı. Verilerin istatistiksel analizleri GraphPad Prism programında değerlendirildi. İstatistiksel anlamlılık p<0,05 olarak kabul edildi. Bulgular: Yeni kemik alan yüzdesinin test grubunda (%43,75) kontrol grubundan (%28,35) istatistiksel olarak anlamlı yüksek olduğu tespit edildi (p<0,05). Rezidüel greft alanı, test grubunda 0,56 ±0,21 mm2 iken kontrol grubunda 0,89±0,17 mm2 olarak saptandı (p<0,05). Fibröz doku alanının, test grubu (1,00±0,27 mm2) ile kontrol grubunda (1,10±0,23 mm2) benzer olduğu gözlendi (p>0,05). Sonuç: Bu çalışmanın sonuçları, yönlendirilmiş kemik rejenerasyonunu takiben oral yolla kullanılan D3 vitamininin ratların kritik boyuttaki kalvaryal defektlerinde yeni kemik dokusu oluşumunu artırdığını göstermiştir.Publication Metadata only Yaşlanma ve periodontal sağlık(Türkiye Klinikleri (Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş.), 2022-01-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; ÖZTÜRK H., AĞRALI Ö. B., DOĞAN B.Publication Metadata only Treatment of Necrotizing Periodontal Disease In Patients with COVID-19 History: Two Case Reports(2022-11-10) ÖZTÜRK ÖZENER, HAFİZE; DOĞAN, BAŞAK; DUMAN I., İŞLEK İ., ÖZTÜRK H., DOĞAN B.