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UĞURLU, TİMUÇİN

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TİMUÇİN

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Subject: Life Sciences ×

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Now showing 1 - 5 of 5
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    Preformulation studies of chitosan nanoparticles for intranasal vaccine administration
    (2023-05-31) ÖZER ÖNDER, SETENAY; UĞURLU, TİMUÇİN; Özer Önder S., Uğurlu T.
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    PublicationOpen Access
    Synthesis and characterization of chitosan-PVA hydrogel containing PEGylated recombinant epidermal growth factor on cell culture for wound healing substitute
    (2022-08-01) SEZER, ALİ DEMİR; UĞURLU, TİMUÇİN; ŞAHBAZ, SEVİNÇ; Doğan M., Şahbaz S., Uğurlu T., Sezer A. D.
    The aim of the current study was to assess the physicochemical characteristics and wound healing activity of chitosan-polyvinyl alcohol (PVA) crosslinked hydrogel containing recombinant human epidermal growth factor (rh-EGF) or recombinant mouse epidermal growth factor (rm-EGF). The hydrogels were prepared and analyses were made of the morphological properties, viscosity, water absorption capacity, mechanical and bio-adhesive properties. The viscosity of the formulations varied between 14.400 - 48.500 cPs, with the greatest viscosity values determined in K2 formulation. F2 formulation showed the highest water absorption capacity. According to the studies of the mechanical properties, H2 formulation (0.153±0.018 N.mm) showed the greatest adhesiveness and E2 (0.245±0.001 mj/cm2 ) formulation, the highest bio-adhesion values. Hydrogels were cytocompatible considering in vitro cell viability values of over 76% on human keratinocyte cells (HaCaT, CVCL-0038) and of over 84% on human fibroblast cells (NIH 3T3, CRL-1658) used as a model cell line. According to the BrdU cell proliferation results, B1 (197.82±2.48%) formulation showed the greatest NIH 3T3 and C1 (167.43±5.89%) formulation exhibited the highest HaCaT cell proliferation ability. In addition, the scratch closure assay was performed to assess the wound healing efficiency of formulation and the results obtained in the study showed that F2 formulation including PEGylated rh-EGF had a highly effective role. Keywords: Chitosan. rh-EGF. Hydrogel. Texture analyzer. Cell culture.
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    Aseklofenak içeren ağızda dağılan tablet formülasyonlarının hazırlanması ve in-vitro değerlendirilmesi
    (2021-01-12) UĞURLU, TİMUÇİN; ŞAHBAZ, SEVİNÇ; Erdoğan K. O., Uğurlu T., Şahbaz S.
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    Probiyotik tablet formülasyonlarında kullanılan yardımcı maddelerin bakteri sağ kalımına etkisinin değerlendirilmesi
    (2023-03-19) ŞAHBAZ, SEVİNÇ; RAYAMAN, ERKAN; UĞURLU, TİMUÇİN; Kandur B., Şahbaz S., Rayaman E., Uğurlu T.
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    PublicationOpen Access
    A recent review of the utilization of 3D printing in the development and manufacturing of pharmaceutical dosage forms
    (2024-01-01) KERİMOĞLU, OYA; UĞURLU, TİMUÇİN; Alenezi E. E., KERİMOĞLU O., UĞURLU T.
    Three-dimensional (3D) printing has paved the way in pharmaceutical applications. This innovative methodology presents novel and inventive remedies for patients and the pharmaceutical sector. Moreover, the benefits of this approach encompass the mitigation of adverse effects, customization of formulations for patients with rare medical conditions, and enhancement of therapeutic effectiveness. The objective of our review was to offer a comprehensive survey of the advancements observed in the drug delivery systems that were produced. A thorough inspection has assessed the diverse dosage forms developed using the three-dimensional printing technique (3DP), especially in the last five years. The pharmaceutical industry places significant emphasis on the benefits of developing dosage forms with intricate designs and geometries, incorporating multiple active ingredients, and tailored release profiles due to their versatility and related advantages. Drug delivery systems can be classified into different modalities, tablets, capsules, suppositories, transdermal delivery systems, microneedles, vaginal delivery systems, and nanoscale dosage forms. The utilization of our classification system facilitates researchers\" task of evaluating publications and effectively pinpointing further opportunities for research exploration.