Person: RAYAMAN, ERKAN
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RAYAMAN
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ERKAN
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Publication Metadata only İmhası istenilen ürünler(2015-12-01) CÜCÜ, AYŞEN; BİTİŞ, LEYLA; RAYAMAN, ERKAN; ŞAHBAZ, SEVİNÇ; AKGÜN ÖLMEZ, SEVCAN GÜL; Cücü A., Bitiş L., Rayaman E., Şahbaz S., Akgün Ölmez S. G.Publication Open Access Effect of antibiotics on polymorphonuclear leukocyte functions and myeloperoxidase activity, glutathione and malondialdehyde levels in allergic asthma(2015-03-31) RAYAMAN, ERKAN; Rayaman, Pervi̇N; Rayaman, Erkan; Çevi̇Kbaş, Adi̇Le; Demi̇Rtunç, Refi̇K; Özer Şehi̇Rli̇, Ahmet; Alagöz, Şeyda Gül; Gürer, Ümran SoyoğulWe investigated the effect of ciprofloxacin, rifampicine and doxycycline on myeloperoxidase (MPO) activity, glutathione (GSH) and malondialdehyde (MDA) levels in allergic asthma patients and healthy volunteers. Polymorphonuclear leukocytes (PMNs) were isolated with ficoll-hypaque gradient centrifugation method. MPO activity was assayed with modified o-dianisidine, GSH by Ellman's and MDA levels by Beuge's method. PMN functions and MDA levels of patients significantly decreased when compared with healthy volunteers. Ciprofloxacin significantly increased PMN functions, MPO activity and MDA levels of both groups. We have demonstrated that ciprofloxacin has beneficial effects on MPO activity and PMN functions in allergic asthma patients and healthy volunteers.Publication Metadata only Bazı bitki ekstreleri ile saf fenolik bileşiklerin probiyotik ve patojen mikroorganizmalar üzerine antimikrobiyal aktivitesinin araştırılması(2019-12-10) RAYAMAN, PERVİN; RAYAMAN, ERKAN; TAŞKIN, TURGUT; KARPUZ E., RAYAMAN P., RAYAMAN E., TAŞKIN T.Publication Metadata only Phenolic composition and biological properties of Achillea nobilis L. subsp neilreichii (Kerner) Formanek(ELSEVIER, 2018) RAYAMAN, ERKAN; Taskin, Duygu; Taskin, Turgut; Rayaman, ErkanAchillea species are widely distributed medicinal plant throughout the world and have been used since ancient time. There are many reports about the traditional use and highly bioactive compounds of these plants. Therefore, it is fundamental to study in detail the chemical composition and biological activities of Achillea species. Thus, the objective of this study was to determine for the first time the effects of methods/solvents on biological activities (antioxidant, antimicrobial, and anti-urease) of Achillea nobilis L.subsp. neilreichii (Kerner) Formanek 15 extracts obtained from different extraction methods/solvents and then to analysis the phenolic contents of the active extracts. The phenolic contents in ethyl acetate and ethanol extracts, which showed strongest phenolic contents and antioxidant activity were analysed separately by high-performance liquid chromatography with diode array detection and were confirmed by liquid chromatography with quadrupole time-of-flight mass spectrometry using targeted mass spectra techniques with accurate mass. The active phenolic compounds were identified as dicaffeoylquinic acid, luteolin-7-O-glucoside, orientin, vitexin, luteolin, quercetin-methyl-ether, isorhamnetin-glucoside in ethyl acetate extract; chlorogenic acid luteolin-7-O-glucoside, quercetin-methyl-ether, luteolin, orientin, vitexin, dicaffeoylquinic acid, apigenin-6,8-di-C-glucoside, luteolin hexoside hexoside in ethanol extract. As a result of this study, dicaffeoylquinic acid, isorhamnetin-glucoside, chlorogenic acid, and apigenin-6,8-di-C-glucoside compounds were analysed for the first time in Achillea nobilis L. subsp. neilreichii (Kerner) Formanek. Therefore, it is thought that ethanol and ethyl acetate extracts can be used as a natural source in the future for food and pharmaceutical industry.Publication Metadata only Development and characterization of vancomycin-loaded levan-based microparticular system for drug delivery(TAYLOR & FRANCIS LTD, 2017) SEZER, ALİ DEMİR; Sezer, Ali Demir; Sarilmiser, Hande Kazak; Rayaman, Erkan; Cevikbas, Adile; Oner, Ebru Toksoy; Akbuga, JulideEncapsulation of vancomycin (VANCO) into biodegradable levan microparticles was achieved using a simple preparation technique. Microparticles were prepared by using levan polysaccharide produced by a halophilic bacterium Halomonas smyrnensis AAD6(T). To optimize efficiency of encapsulation process by precipitation method, three parameters were studied: drug and polymer concentrations and preparation rotating speed. The particles were characterized in vitro. The size of levan microparticles was changed between 0.404 mu m and 1.276 mu m. The surface charge was detected between +4.1 mV and +6.5 mV. The highest drug encapsulation capacity of the system was 74.7% and was depending on the polymer concentration. In dissolution studies, initial burst effect around 10-20% from all the formulations was observed and then the release was slowed down and continued at a constant level. In vitro antibiotic release from the microparticles was controlled with the drug carrier system and release fit to Higuchi kinetic model. All the released samples collected at different time intervals during dissolution studies have exhibited intrinsic bactericidal activity against Bacillus subtilis ATCC 6633. WST-1 cell proliferation and viability studies showed that VANCO-loaded levan microparticles at concentrations between 100 mu g/mL and 1000 mu g/mL were nontoxic to L929 cells. As conclusion, levan microparticulate system could be a potential carrier of antibiotic drugs such as VANCO.Publication Metadata only In vitro and In vivo biological activities and phenolic characterization of Thymus praecox subsp. skorpilii var. skorpilii(SPRINGER, 2019) RAYAMAN, ERKAN; Taskin, Turgut; Cam, Muhammet Emin; Taskin, Duygu; Rayaman, ErkanThymus species are used as food and spices in several Mediterranean and other countries as well as for medical purposes on account of their biological properties. The extraction procedures and solvents are an important step in processing bioactive constituents from the plant materials. Therefore, the aim of this study was to evaluate in vitro antioxidant, anticholinesterase, antimicrobial, anti-urease and in vivo anti-inflammatory activities of Thymus praecox subsp. skorpilii var. skorpilii using a variety of extracts. In addition, the phenolic characterization of the fraction methanol extract, which showed the highest phenolic contents and the strongest antioxidant and anticholinesterase activity were performed by HPLC-DAD and LC-MS/MS techniques. In the present study, the fraction methanol and direct methanol extracts exhibited strong DPPH, ABTS, and ferric reducing activity and strong antibacterial activity against Staphylococcus epidermidis strains. The fraction chloroform and fraction petroleum ether extracts showed the strongest anti-urease activity and also, the petroleum ether extract exhibited strong antibacterial activity against the Staphylococcus aureus strain. The fraction methanol and direct methanol extracts showed in vivo anti-inflammatory activity very similar to each other. As a result of this study, chlorogenic acid, luteolin-7-O-glucoside, 3-O-feruloylquinic acid, quercetin-3-O-hexoside, and apigenin-7-O-glucuronide compounds were analyzed for the first time in the methanol extract of the plant. This latter study revealed the effects of the extraction methods and phenolic compounds on its biological properties.Publication Metadata only Characterization of the Biological Activity and Phenolics in Achillea lycaonica(TAYLOR & FRANCIS INC, 2018) RAYAMAN, ERKAN; Taskin, Turgut; Taskin, Duygu; Rayaman, Erkan; Dikpinar, Tugce; Suzgec-Selcuk, Sevda; Arabaci, TuranThe purpose of this study was to comparatively evaluate for the first time the antioxidant, antimicrobial, and antiurease effects of A. lycaonica extracts obtained using three extraction methods and five solvents followed by identification of the phenolic compounds obtained by Soxhlet extraction with ethyl acetate and maceration with chloroform that showed the highest total phenolic and flavonoid contents with antioxidant and antiurease activity. The phenolic compounds were identified to be chlorogenic acid, caffeic acid, rutin, dicaffeoylquinic acid, salicylic acid, luteolin, quercetin, naringenin, apigenin, and 8-hydroxy- salvigenin. Among the solvent extraction procedures, Soxhlet approach was found to have higher recoveries than other approaches. The results of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays showed that the 1: 1 ethanol-water Soxhlet, ethanol ultrasonic bath, and ethyl acetate Soxhlet extraction methods had the highest DPPH antioxidant activities. The ethyl acetate Soxhlet extraction method showed the highest 2, 2'-azino-bis(3-ethylbenzthiazoline- 6-sulfonic acid) diammonium salt (ABTS) and ferric reducing antioxidant power (FRAP) antioxidant activity. In addition, the chloroform maceration extraction method exhibited the highest antiurease activity. Therefore, 1: 1 Soxhlet ethanol-water, ultrasonic bath ethanol, and Soxhlet ethyl acetate extracts may be used in medicine and food production as natural antioxidant sources. In addition, maceration with chloroform may provide a potential antiurease agent.Publication Open Access Potential Adjuvant Effects of Nigella sativa Seeds to Improve Specific Immunotherapy in Allergic Rhinitis Patients(KARGER, 2010) GÜRBÜZ, BURÇAK; Isik, Huelya; Cevikbas, Adile; Gurer, Umran Soyogul; Kiran, Bayram; Uresin, Yagiz; Rayaman, Pervin; Rayaman, Erkan; Gurbuz, Burcak; Buyukozturk, SunaObjective: To investigate the effects of Nigella sativa seed supplementation on symptom levels, polymorphonuclear leukocyte (PMN) functions, lymphocyte subsets and hematological parameters of allergic rhinitis. Subjects and Methods: Twenty-four patients randomly selected from an experimental group of 31 (mean age 34 years) sensitive to house dust mites with allergic rhinitis and a control group of 8 healthy volunteers (mean age 23 years) were treated with allergen-specific immunotherapy in conventional doses for 30 days. After a month of immunotherapy, 12 of the 24 patients and the 8 healthy volunteers were given N. sativa seed supplementation (2 g/day orally) for 30 days. The remaining 12 patients continued only on immunotherapy during the same period. The other 7 patients were given 0.1 ml saline solution subcutaneously once a week as a placebo. The symptom scores, PMN functions, lymphocyte subsets and other hematological parameters were evaluated before and after all treatment periods. Results: There was a statistically significant increase in the phagocytic and intracellular killing tivities of PMNs of patients receiving specific immunotherapy, especially after the addition of N. sativa seed. The CD8 counts of patients receiving specific immunotherapy plus N. sativa seed supplementation significantly increased compared to patients receiving only specific immunotherapy. PMN functions of healthy volunteers significantly increased after N. sativa seed supplementation compared to baseline. Conclusion: N. sativa seed supplementation during specific immunotherapy of allergic rhinitis may be considered a potential adjuvant therapy. Copyright (C) 2010 S. Karger AG, BaselPublication Metadata only Microbiological quality and portion analysis of döner sandwiches(2017-03-01) OMURTAG KORKMAZ, BURCU İREM; RAYAMAN, ERKAN; RAYAMAN, PERVİN; SOYOĞUL GÜRER, ÜMRAN; OMURTAG KORKMAZ B. İ., RAYAMAN E., RAYAMAN P., SOYOĞUL GÜRER Ü.