Person: CESUR, SÜMEYYE
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
CESUR
First Name
SÜMEYYE
Name
19 results
Search Results
Now showing 1 - 10 of 19
Publication Metadata only Fabrication and characterization of pla/sa/ha composite nanofiber by electrospinning for bone tissue engineering applications(2018-07-18) CESUR, SÜMEYYE; EKREN, NAZMİ; KILIÇ, OSMAN; OKTAR, FAİK NÜZHET; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; GÜNDÜZ, OĞUZHAN; Cesur S., Ekren N., Kılıç O., Oktar F. N., Bilğiç Alkaya D., Ayaz Seyhan S., Ege Z. R., Gündüz O.Publication Metadata only Loading of tuberculosis drugs to nanofiber structures, fiber optimization(2019-06-28) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Onurlu H. İ., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.uberculosis is a disease caused by a bacillus called mycobacterium tuberculosis which can be seen in other organs, especially in the lungs. Tuberculosis is an infectious, infectious, inflammatory, acute or chronic-trending bacterial infection. Since the treatment is insufficient with a single drug and the bacilli are resistant to this antibiotic, various antituberculosis drugs are used side by side during the treatment. Side-by-side use of the drugs breaks the resistance of the bacteria but creates a lot of side effects for the patient. We aim to reduce the existing side effects by loading the active agents of rifampicin, isoniazid, pyrazinamide and ethambutol, which are used as antituberculosis drugs, to a biodegradable nanofib. Primarily, PCL polymer material was dissolved in DMF: THF (v / v). After preparing PCL solution in 3%, 6%, 9%, 12% and 15% concentrations, optimization studies were performed by using electrospin device at various voltages. The SEM images of the obtained PCL fibers were examined and drug loading was performed at the suitable PCL concentration. In the planned study, FTIR images of the fibers loaded with the drug will be examined and controlled drug oscillations will be provided at the stomach and intestinal pH as an in vitro trial and spectrophotometric measurements will be taken. The release of drugs loaded into nanofibers are slower due to the wide surface area of the nanofibers, which offers a more controlled drug release.Publication Metadata only Preparation and characterization of silver-doped hydroxyapatite from seashell by different methods(2018-09-08) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; , Ayaz Seyhan S., Bilğiç Alkaya D., Öztürk B. N., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Metadata only Hydroxyapatıte is bıomaterıals: its chemıcal synthesıs characterızatıon shell of cypaea annulus(2018-09-08) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Bilğiç Alkaya D., Ayaz Seyhan S., Öztürk B. N., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Metadata only Preparatıon of hydroxyapatıte biomaterıals for benzoic acid delıvery from scotch bonnets seashell by microwave processing(2018-09-08) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Öztürk B. N., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Metadata only Inula helenium loaded nanofibers mat for medical application(2023-06-28) CESUR, SÜMEYYE; AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; GÜNDÜZ, OĞUZHAN; SULUTAŞ R. B., CESUR S., AYAZ SEYHAN S., BİLĞİÇ ALKAYA D., GÜNDÜZ O.Cancer is one of the leading causes of death worldwide. Biomaterials produced with nanotechnological methods for cancer treatment are more effective and complementary than existing treatment strategies. Nanofiber scaffolds are biomaterials that can be used in cancer treatment and can be produced in composites with biocompatible polymers and anti-cancer drugs, plant extracts. The electrospin device used for the production of these materials creates nanofiber networks by providing the electric field between the needle tip and the metal collector, which transmits the polymer solution. PLA is a biodegradable synthetic material preferred in tissue engineering studies and is a biocompatible, high mechanical strength, low cost polymer suitable for use in drug delivery systems. PVP is a polymer with good adhesion, high physiological compatibility, low toxicity and easily soluble in most organic solvents, especially used in the pharmaceutical industry. The extract of the plant Inula helenium, whose main component consists of sesquiterpene lactones, is also used in treatments for cancer. This component, which has various biological activities, has a significant anti-cancer effect. In this study, the polymer ratio used in the production of nanofiber scaffold obtained by adding Inula helenium extract is 75% PLA-chloroform / 25% PVP-ethanol and 1% Tween 80. The surface morphology of the produced fiber material was determined according to the results in the SEM images. The diameters of the fibers were measured and given in the histogram graph. FT-IR for chemical structure between bonds and DSC tests for thermal behavior analysis were applied. Tensile test was performed for mechanical analysis. Swelling-degradation test was performed and drug release kinetic data were calculated by UV spectrophotometer. In addition, its effectiveness on cancerous cells was examined by MTT analysis. In conclusion, Inula helenium extract-loaded nanofibers can reduce the risk of local recurrence of cancer after surgery and can be directly implanted into solid tumor cells for treatmentPublication Metadata only Synthesis of medicinal plant based bioactive electrospun nanofibrous mats and their effect on the antioxidant activity(2022-06-24) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Demirel A. B., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Production and Characterization of a Dual Drug Delivery System of Memantine and Naringenin by Electrospinning Method(2023-06-30) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Birinci A., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Open Access Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery(2022-09-01) OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; AYAZ SEYHAN S., Alkaya D., Cesur S., OKTAR F. N., GÜNDÜZ O.The marine species are specially used for the fabrication of bioceramic nano-powders with natural methods for their use in controlled drug delivery. However, there are only very limited studies regarding the production and synthesis of hydroxyapatite (HA)-based drug delivery systems from marine structures. In this study, poly (vinyl alcohol) (PVA) containing Rifampicin (RIF)-loaded Orange Spiny Oyster Seashell (Spondylus barbatus) hydroxyapatite (HA) composite is synthesized by an in situ ultrasound-assisted method. All samples were analyzed by X-ray diffraction (XRD), Fourier transforms infrared (FTIR) spectroscopy, and Scanning electron microscope (SEM), respectively. The in vitro drug release tests of the obtained samples were performed in a phosphate-buffered medium (PBS) at 37 degrees C. Drug release was evaluated according to five varying kinetic models. In vitro RIF release from HA/PVA composite in phosphate buffer (pH 7.4) showed prolonged sustained drug release. From the drug release kinetic models, Higuchi and Korsmeyer-Peppas were found to be the best model for the three ratios based on the correlation coefficient. The diffusion component is less than 0.5, which indicates quasi-fickian diffusion. From the kinetic study results, the RIF-loaded marine phase composite has potential use in drug delivery applications as it shows positive sustained drug release behavior.Publication Metadata only Characterization and application of silver nanoparticles decorated electrospun nanofiber loaded with naringenin(2022-06-24) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Birinci A., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Nanoparticles are an innovative class of functional materials. Silver nanoparticles (AgNPs) are extensively applied in different fields of science, such as biomedical science, including antibacterial, antiviral, anti-inflammatory, and anticancer therapies. Also, AgNPs are being used to produce various biomedical products to prevent infection. The application of AgNPs has been widened due to recent advances in nanotechnology. AgNPs have several important implications including medical diagnostics, therapeutics, antioxidant, antibacterial, and cytotoxic properties. Many natural biomolecules in plants (inactivated plant tissue, plant extracts and living plant) such as proteins/enzymes, amino acids, polysaccharides, alkaloids, alcoholic compounds, and vitamins could be involved in bioreduction, formation and stabilization of AgNPs. Naringenin (4′,5,7-trihydroxyflavanone) (NRG) is a bioflavonoid widely present in fruits; it has been reported to have antioxidant, free radical scavenging, anticancer, anti-inflammatory, immunomodulating and memory enhancing properties. Its antioxidant effects may make NRG a potential drug for treating Alzheimer disease (AD). Recently, NRG was found to exhibit neuroprotective effect in models of Parkinson's disease (PD) and AD, such as the ICV-STZ-induced mode of AD and the 6-OHDA model of PD. Nanocomposite materials consisting of metallic nanoparticles incorporated in or with polymers have attracted much attention because of their distinct optical, electrical and catalytic properties, which have potential applications in the fields of catalysis, bioengineering, photonics, and electronics. Silver nanoparticles have been immobilized into polymer-based nanofibers to introduce hybrid multifunctional substrates for a variety of applications. In this study, nanostructured metal-polymer hybrid (AgNPsNRG-PLA) nanofibers were obtained by electrospinning technique.The nanostructured metal-polymer hybrid (AgNPs-NRG-PLA) nanofibers were characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), thermal analysis (DSC) and tensile strength and physical analyzes such as density, surface tension, particle viscosity were performed.