Publication: Loading of tuberculosis drugs to nanofiber structures, fiber optimization
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Date
2019-06-28
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Abstract
uberculosis is a disease caused by a bacillus called mycobacterium tuberculosis which can be seen in other organs,
especially in the lungs. Tuberculosis is an infectious, infectious, inflammatory, acute or chronic-trending bacterial
infection. Since the treatment is insufficient with a single drug and the bacilli are resistant to this antibiotic, various
antituberculosis drugs are used side by side during the treatment. Side-by-side use of the drugs breaks the resistance
of the bacteria but creates a lot of side effects for the patient. We aim to reduce the existing side effects by loading
the active agents of rifampicin, isoniazid, pyrazinamide and ethambutol, which are used as antituberculosis drugs, to
a biodegradable nanofib. Primarily, PCL polymer material was dissolved in DMF: THF (v / v). After preparing PCL
solution in 3%, 6%, 9%, 12% and 15% concentrations, optimization studies were performed by using electrospin
device at various voltages. The SEM images of the obtained PCL fibers were examined and drug loading was
performed at the suitable PCL concentration. In the planned study, FTIR images of the fibers loaded with the drug
will be examined and controlled drug oscillations will be provided at the stomach and intestinal pH as an in vitro trial
and spectrophotometric measurements will be taken. The release of drugs loaded into nanofibers are slower due to
the wide surface area of the nanofibers, which offers a more controlled drug release.
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Sağlık Bilimleri, Mühendislik ve Teknoloji, Health Sciences, Engineering and Technology, Klinik Tıp (MED), Mühendislik, Bilişim ve Teknoloji (ENG), Clinical Medicine (MED), Engineering, Computing & Technology (ENG), Antituberculosis, biodegradablepolymer, electrospin, PCL, drug release
Citation
Onurlu H. İ., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O., \"Loading of tuberculosis drugs to nanofiber structures, fiber optimization\", 2. International Eurasian Conference on Biological and Chemical Sciences, Ankara, Türkiye, 28 - 29 Haziran 2019, ss.1