Person: CESUR, SÜMEYYE
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CESUR
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SÜMEYYE
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Publication Metadata only Multilayer patches for the treatment of corneal perforations caused by infections(2022-09-28) CESUR, SÜMEYYE; TINAZ, GÜLGÜN; ŞENGÖR, MUSTAFA; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Kijeńska-Gawrońska ., İlhan E., Cesur S., Sulutaş R. B., Pilavcı E., Dalbayrak B., Kaya E., Arısan E. D., Tınaz G., Şengör M., et al.Publication Open Access Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery(2022-09-01) OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; AYAZ SEYHAN S., Alkaya D., Cesur S., OKTAR F. N., GÜNDÜZ O.The marine species are specially used for the fabrication of bioceramic nano-powders with natural methods for their use in controlled drug delivery. However, there are only very limited studies regarding the production and synthesis of hydroxyapatite (HA)-based drug delivery systems from marine structures. In this study, poly (vinyl alcohol) (PVA) containing Rifampicin (RIF)-loaded Orange Spiny Oyster Seashell (Spondylus barbatus) hydroxyapatite (HA) composite is synthesized by an in situ ultrasound-assisted method. All samples were analyzed by X-ray diffraction (XRD), Fourier transforms infrared (FTIR) spectroscopy, and Scanning electron microscope (SEM), respectively. The in vitro drug release tests of the obtained samples were performed in a phosphate-buffered medium (PBS) at 37 degrees C. Drug release was evaluated according to five varying kinetic models. In vitro RIF release from HA/PVA composite in phosphate buffer (pH 7.4) showed prolonged sustained drug release. From the drug release kinetic models, Higuchi and Korsmeyer-Peppas were found to be the best model for the three ratios based on the correlation coefficient. The diffusion component is less than 0.5, which indicates quasi-fickian diffusion. From the kinetic study results, the RIF-loaded marine phase composite has potential use in drug delivery applications as it shows positive sustained drug release behavior.Publication Open Access A novel strategy as a potential rapid therapy modality in the treatment of corneal ulcers: Fluconazole/vancomycin dual drug-loaded nanofibrous patches(2023-01-01) CESUR, SÜMEYYE; BİNGÖL ÖZAKPINAR, ÖZLEM; TINAZ, GÜLGÜN; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; CESUR S., Ilhan E., Pilavci E., Sulutas R. B., Gurboga M., BİNGÖL ÖZAKPINAR Ö., Kaya E., Heljak M., TINAZ G., OKTAR F. N., et al.Corneal ulcer, which is brought on by a breach in the epithelial barrier, is a dangerous infection of the avascular corneal stroma. New treatment strategies are needed, suppressing the aggressive nature of the disease and including a combination of different drugs. In this study, vancomycin (VAN) and fluconazole (FLU) dual-drug loaded dual-layered polyvinyl alcohol and gelatin (PVA/GEL) nanofibrous patches are produced by electrospinning. Scanning electron microscopy (SEM) images show smooth surfaces are obtained for both pure and drug-loaded nanofibrous patches. The tensile test results report that loading the FLU and VAN separately into the PVA/GEL patches decrease both the tensile strength and elongation at break and it is further reduced when combining two drug-loaded layers in one patch. According to drug release results, the FLU and VAN-loaded nanofibrous patches show a controlled release profile extending up to 96 h. Moreover, PVA/GEL/FLU, PVA/GEL/VAN, and PVA/GEL/FLU/VAN nanofibrous patches display significant antimicrobial activity against Candida albicans and Staphylococcus aureus. SEM, 4\"-6diamidynofenyloindol (DAPI) staining, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay show that PVA/FLU and PVA/GEL/FLU/VAN nanofibrous patches have a superior effect on NIH3T3 cell spreading and proliferation. The novelty of this study lays in the development of a potential dual drug rapid treatment for corneal ulcers of aggressive nature.Publication Metadata only Fluconazole and cinnamaldehyde loaded-multilayer elektrospun nanofibers for the treatment of fungal keratitis(2022-06-24) CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; İlhan E., Cesur S., Oktar F. N., Gündüz O.Inflammation of the cornea due to physical, chemical and infectious causes is known as keratitis[1]. Fungi are one of the most challenging species to diagnose and treat among the organisms that cause keratitis. Moreover, fungal keratitis has been proven to be more virulent and destructive than keratitis caused by bacterias[2]. In this study, two-layer polyvinyl alcohol and gelatin (PVA/GEL) nanofibers loaded with different biological agents, which accelerate wound closure by suppressing the disadvantages of traditional methods in the treatment of fungal keratitis, were produced by the electrospinning method. Cinnamaldehyde (CA), an FDA-approved volatile molecule found in cinnamon essential oil, and fluconazole (FLU), an antifungal drug, were incorporated into PVA/GEL nanofibers to inhibit the growth and biofilm formation of Candida albicans, one of the pathogens that cause fungal keratitis. The morphology, and chemical structures of the produced pure (PVA/GEL), FLU loaded (PVA/GEL/FLU), CA loaded (PVA/GEL/CA), and combined FLU and CA loaded (PVA/GEL/COM) nanofibers were analysed by scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FT-IR), respectively. The mechanical analysis and drug release kinetics of the nanofibers were investigated. PVA/GEL/FLU, PVA/GEL/CA and PVA/GEL/FLU/COM nanofibers were evaluated for their antifungal and antibiofilm activity against Candida albicans. Results showed that PVA/GEL/FLU and PVA/GEL/COM nanofibers have significant antifungal activity and inhibited biofilm formation by 37% and 49%, respectively. The originality of this study lays in the design of the multilayer electrospun nanofibers, which are loaded with both biofilm inhibitor agent and an antifungal drug. This kind of construct can be utilised in the treatment of fungal keratitis and to produce patches that accelerate wound healing and allow controlled release of the bio-active agents.