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CESUR, SÜMEYYE

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CESUR

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SÜMEYYE

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2022 - 20234
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Now showing 1 - 4 of 4
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    PublicationOpen Access
    Microfluidic systems for neural tissue engineering
    (Elsevier Science, Oxford/Amsterdam , 2023-01-01) CESUR, SÜMEYYE; ULAĞ, SONGÜL; GÜNDÜZ, OĞUZHAN; Cesur S., Ulağ S., Gündüz O.
    Damage to the nervous system due to illness or injury can cause serious and lasting loss of function or even fatal consequences. It is necessary to develop new treatment strategies to restore the function of the damaged nervous system.The optimal environment for nerve cell proliferation and differentiation is provided by neural tissue engineering. It aims to improve a new approximation for the therapy of nervous system diseases. Compared to 2D cell culture techniques, 3D cell culture systems ensure a more biomimetic environment and encourage more differentiation of cells. However, certain cell culture parameters have limitations in spatio-temporal control. With the advent of microfluidic systems, it can control the spatio-temporal dispersion of physical and chemical signals at the cellular level. In this section, microfluidic systems are explored as a tool to target both physical and chemical injury and recreate the post-injury environment, to study nerve injury at the cellular grade.
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    PublicationOpen Access
    Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery
    (2022-09-01) OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; AYAZ SEYHAN S., Alkaya D., Cesur S., OKTAR F. N., GÜNDÜZ O.
    The marine species are specially used for the fabrication of bioceramic nano-powders with natural methods for their use in controlled drug delivery. However, there are only very limited studies regarding the production and synthesis of hydroxyapatite (HA)-based drug delivery systems from marine structures. In this study, poly (vinyl alcohol) (PVA) containing Rifampicin (RIF)-loaded Orange Spiny Oyster Seashell (Spondylus barbatus) hydroxyapatite (HA) composite is synthesized by an in situ ultrasound-assisted method. All samples were analyzed by X-ray diffraction (XRD), Fourier transforms infrared (FTIR) spectroscopy, and Scanning electron microscope (SEM), respectively. The in vitro drug release tests of the obtained samples were performed in a phosphate-buffered medium (PBS) at 37 degrees C. Drug release was evaluated according to five varying kinetic models. In vitro RIF release from HA/PVA composite in phosphate buffer (pH 7.4) showed prolonged sustained drug release. From the drug release kinetic models, Higuchi and Korsmeyer-Peppas were found to be the best model for the three ratios based on the correlation coefficient. The diffusion component is less than 0.5, which indicates quasi-fickian diffusion. From the kinetic study results, the RIF-loaded marine phase composite has potential use in drug delivery applications as it shows positive sustained drug release behavior.
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    PublicationOpen Access
    A novel strategy as a potential rapid therapy modality in the treatment of corneal ulcers: Fluconazole/vancomycin dual drug-loaded nanofibrous patches
    (2023-01-01) CESUR, SÜMEYYE; BİNGÖL ÖZAKPINAR, ÖZLEM; TINAZ, GÜLGÜN; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; CESUR S., Ilhan E., Pilavci E., Sulutas R. B., Gurboga M., BİNGÖL ÖZAKPINAR Ö., Kaya E., Heljak M., TINAZ G., OKTAR F. N., et al.
    Corneal ulcer, which is brought on by a breach in the epithelial barrier, is a dangerous infection of the avascular corneal stroma. New treatment strategies are needed, suppressing the aggressive nature of the disease and including a combination of different drugs. In this study, vancomycin (VAN) and fluconazole (FLU) dual-drug loaded dual-layered polyvinyl alcohol and gelatin (PVA/GEL) nanofibrous patches are produced by electrospinning. Scanning electron microscopy (SEM) images show smooth surfaces are obtained for both pure and drug-loaded nanofibrous patches. The tensile test results report that loading the FLU and VAN separately into the PVA/GEL patches decrease both the tensile strength and elongation at break and it is further reduced when combining two drug-loaded layers in one patch. According to drug release results, the FLU and VAN-loaded nanofibrous patches show a controlled release profile extending up to 96 h. Moreover, PVA/GEL/FLU, PVA/GEL/VAN, and PVA/GEL/FLU/VAN nanofibrous patches display significant antimicrobial activity against Candida albicans and Staphylococcus aureus. SEM, 4\"-6diamidynofenyloindol (DAPI) staining, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay show that PVA/FLU and PVA/GEL/FLU/VAN nanofibrous patches have a superior effect on NIH3T3 cell spreading and proliferation. The novelty of this study lays in the development of a potential dual drug rapid treatment for corneal ulcers of aggressive nature.
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    PublicationOpen Access
    Characterization of scaffolds for neural tissue engineering
    (Elsevier Science, Oxford/Amsterdam , 2023-01-01) CESUR, SÜMEYYE; ULAĞ, SONGÜL; Ulağ S., Cesur S., Ayran M. M., Bozlar M.
    With the advancement of tissue engineering techniques, the repair of nerve injuries has acquired a novel dimension. It is now appropriate to establish a scaffold that entirely mimics the biological and mechanical properties of real human tissue using tissue engineering techniques. In order to determine how well synthetic and/or natural polymers can construct optimal scaffolds, cells and growth factors can also be investigated to enhance the functionality of scaffolds. Studies are underway to design biodegradable, biocompatible, electrically conductive, and immunologically inert scaffolds. The primary objective is to accurately simulate the extracellular matrix in the human body and to expose the conjunction of biochemical, topographic, and electrical features employing different polymers, cells, and growth hormones. This chapter focuses on the importance of processing/engineering and characterization techniques for neural tissue scaffolds used to regenerate neural diseases.