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ATASOY, BESTE MELEK

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BESTE MELEK

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2012 - 20143
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Author: ALSAN ÇETİN, İLKNUR × Start date: 2010 ×

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Now showing 1 - 3 of 3
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    Retrospective Results of Malignant Glioma Patients Receiving Primary and/or Postoperative Radiotherapy and Comparison with Different Prognostic Indices
    (ORTADOGU AD PRES & PUBL CO, 2012) ATASOY, BESTE MELEK; Cetin, Ilknur Alsan; Abacioglu, Ufuk; Cetinkaya, Zuleyha Akgun; Atasoy, Beste Melek; Sengoz, Meric
    Objective: This study aimed to retrospectively evaluate malignant glioma (MG) patients and compare the prognostic factors with different indices. Material and Methods: A total of 204 patients diagnosed as malignant glioma and received primary and/or postoperative radiotherapy (RT) were retrospectively evaluated. Median follow up was nine months (1-90), median survival was 10 months, one-year survival rate was 42%. Of the patients, 16% had grade III anaplastic astrocytoma, 84% had grade IV glioblastoma multiforme. While surgical operation was limited with stereotactic biopsy in 59 (29%) patients, 59 (29%) underwent subtotal and 86 (42%) underwent gross total resection. Prognostic factors affecting survival were tested with univariate and multivariate analyses. Results: In univariate analysis, histology, age, preRT Karnofsky performance status (KPS), preoperative KPS, onset time of symptoms, history of seizures, tumor's not being multicentric, complete surgical resection and RT dose were found to be the factors affecting survival. In multivariate analysis, histology, age, onset time of symptoms, surgery type and RT dose were detected as independent prognostic factors. When the data of our patients were classified according to Radiation Therapy Oncology Group Recursive Partitioning Analysis classification, the survival was 70,13,11,8, 3 months for groups 1 and 3-6, respectively; it was 24, 13, 9, 8 and 4 months for groups 1-5, respectively according to Medical Research Council prognostic index; and 13, 7 and 5 months for groups 1-3, respectively according to Dokuz Eylul University prognostic index (long rank test p<0.0001). Conclusion: As treatment options, contribution of surgery and/or radiotherapy to survival is limited when applied to patients diagnosed with malignant glioma. Additional treatment modalities are needed in addition to these treatment modalities. Prognostic classifications should be used for determination of the treatment.
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    Concurrent chemoradiotherapy with low dose weekly gemcitabine in medically inoperable muscle-invasive bladder cancer patients
    (SPRINGER-VERLAG ITALIA SRL, 2014) ATASOY, BESTE MELEK; Atasoy, B. M.; Dane, F.; Cetin, I. Alsan; Ozgen, Z.; Kefeli, A. Ucuncu; Ibrahimov, R.; Turhal, N. S.; Abacioglu, U.; Turkeri, L.
    We aimed to determine the efficacy and the toxicity of low dose weekly gemcitabine with radiation therapy in medically unfit muscle-invasive bladder cancer patients. Twenty-six patients were included into the retrospective analysis. Weekly gemcitabine was administered 75 mg/m(2) with a median dose of 63 Gy radiation therapy. Clinical target volume was defined as the urinary bladder only in conformal treatment planning. Median follow-up was 51 months (range 14-118 months). Complete response rate was 62.5 %. The 5-year local progression-free survival, disease-specific survival and overall survival rates were 40.6, 59.5 and 58.5 %, respectively. Concurrent chemotherapy was continued in 80.7 % of patients without any interruption. Gemcitabine was stopped due to grade 3 thrombocytopenia (n = 1), cardiac angina (n = 1), chronic obstructive pulmonary disease exacerbation (n = 1) or patients' reluctance (n = 2). Low dose weekly gemcitabine with concurrent radiotherapy is a tolerable regimen and have comparable outcomes with platinum-based combined treatments in muscle-invasive bladder cancer. Prospective randomized trials can help in understanding the safety and efficacy of this treatment specially in medically unfit patients.
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    Nüks yüksek gradli gli̇al tümörlerde bevasi̇zumabin sağkalim üzeri̇ne etki̇si̇
    (2012-04-19) DANE, FAYSAL; ATASOY, BESTE MELEK; ÖZGEN, ZERRİN; ALSAN ÇETİN, İLKNUR; YUMUK, PERRAN FULDEN; Dane F., Atasoy B. M., Aktaş B., Özgen Z., Alsan Çetin İ., Abacıoğlu U., Yumuk P. F.
    Amaç: Bu çalışmada, yüksek gradlı glial tümör tanısı alarak standart tedaviler sonrası nüks etmiş hastalarda tedaviye bevasizumab eklenmesinin sağkalıma etkisinin incelenmesi amaçlanmıştır. Gereç-Yöntem: Şubat 2005-Temmuz 2010 tarihleri arasında 17’si glioblastoma olmak üzere yüksek gradlı glial tümör tanısı almış ortanca yaşı 50 (aralık, 25-62 yaş) toplam 21 (12K:9E) hastanın geriye dönük verileri incelendi. Subtotal eksizyon yapılmış iki ve biyopsi ile tanı konmuş bir hastanın dışında tüm hastalarda (n=18) primer tümör total olarak eksize edilmişti. Postop radyoterapi, eş zamanlı temozolamid 75 mg/m2 ile ortanca 60 Gy olarak uygulanmıştı. Adjuvan dönemde temozolamid 150-200 mg/m2/1-5.günler/28 günde bir olmak üzere ortanca 8 kür (aralık 2-19 kür) devam etmişti. Klinik ve radyolojik progresyon izlenen hastalarda bevasizumab (10 mg/kg/1-14. günler 28. günde bir) tek başına (n=19) ya da irinotekan (n=2) ile birlikte uygulandı. Sağkalım sonuçları Kaplan-Meier eğrisi çizdirilerek elde edildi. Bulgular: Tüm hastalarda cerrahiden itibaren ortanca takip 25 ay (aralık 12-68 ay) idi. Nüks eden hastalardan dördüne cerrahi, altısına Gamma Knife ile stereotaktik radyocerrahi ve altısına da adjuvan temozolamid sonrası yeniden temozolamid (2-10 kür) uygulandı. Standart adjuvan tedavi (kemoradyoterapi ve adjuvan temozolamid) sonrası nüks durumunda doğrudan bevasizumab başlanan dokuz hasta vardı. Nüksten sonra bevasizumab ortanca 6 kür (aralık, 2-27 kür) uygulandı. Hiçbir hastada bevasizumaba bağlı ölüm izlenmedi. Tüm hastalarda cerrahiden itibaren iki yıllık genel sağkalım %62.5 idi. Bevasizumab sonrası ortanca progresyonsuz sağkalım 5 ay (%95 güven aralığı 2.2- 7.8 ay) ve ortanca genel sağkalım 8 ay (%95 güven aralığı 5.1-10.9 ay) idi. Altı aylık progresyonsuz sağkalım %49.1, 6 ve 12 aylık genel sağkalımlar sırasıyla %73.7 ve %39.3 oldu. Sonuç: Nüks yüksek gradlı glial tümörlerde bevasizumab uygulaması diğer tedavilere göre daha yüksek progresyonsuz sağkalım ve genel sağkalım sonuçlarıyla ümit verici bir tedavi olma özelliği göstermektedir.